ATE135372T1 - Verfahren zum nachweis von glucagon-antagonisten - Google Patents
Verfahren zum nachweis von glucagon-antagonistenInfo
- Publication number
- ATE135372T1 ATE135372T1 AT92904367T AT92904367T ATE135372T1 AT E135372 T1 ATE135372 T1 AT E135372T1 AT 92904367 T AT92904367 T AT 92904367T AT 92904367 T AT92904367 T AT 92904367T AT E135372 T1 ATE135372 T1 AT E135372T1
- Authority
- AT
- Austria
- Prior art keywords
- glucagon
- response pathway
- stimulation
- analogs
- glucagon antagonists
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 8
- 102000051325 Glucagon Human genes 0.000 title abstract 6
- 108060003199 Glucagon Proteins 0.000 title abstract 6
- 229960004666 glucagon Drugs 0.000 title abstract 6
- 239000005557 antagonist Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 230000037361 pathway Effects 0.000 abstract 3
- 108010063919 Glucagon Receptors Proteins 0.000 abstract 2
- 102100040890 Glucagon receptor Human genes 0.000 abstract 2
- 230000000638 stimulation Effects 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64134391A | 1991-01-17 | 1991-01-17 | |
| US07/741,931 US5408037A (en) | 1991-01-17 | 1991-08-08 | Methods for detecting glucagon antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE135372T1 true ATE135372T1 (de) | 1996-03-15 |
Family
ID=24571964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92904367T ATE135372T1 (de) | 1991-01-17 | 1992-01-14 | Verfahren zum nachweis von glucagon-antagonisten |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0567562B1 (de) |
| JP (1) | JPH06504913A (de) |
| AT (1) | ATE135372T1 (de) |
| AU (2) | AU663861B2 (de) |
| CA (1) | CA2100874A1 (de) |
| DE (1) | DE69209052T2 (de) |
| DK (1) | DK0567562T3 (de) |
| ES (1) | ES2085004T3 (de) |
| GR (1) | GR3019673T3 (de) |
| WO (1) | WO1992012998A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE161184T1 (de) * | 1990-08-31 | 1998-01-15 | Univ Rockefeller | Glukagon-analoge mit austauschungen oder deletionen in asp-9 |
| US5408037A (en) * | 1991-01-17 | 1995-04-18 | Zymogenetics, Inc. | Methods for detecting glucagon antagonists |
| US5510459A (en) * | 1991-01-17 | 1996-04-23 | Zymogenetics, Inc. | Glucagon antagonists |
| EP0658200B1 (de) * | 1992-08-28 | 2004-12-22 | Novo Nordisk A/S | Glucagonrezeptoren |
| US5776725A (en) * | 1992-08-28 | 1998-07-07 | Zymogenetics, Inc. | Recombinant production of glucagon receptors |
| US5480867A (en) * | 1993-12-29 | 1996-01-02 | The Rockefeller University | Glucagon analogs with serine replacements |
| AR036711A1 (es) * | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
| DK2300035T3 (en) * | 2008-06-17 | 2015-11-16 | Univ Indiana Res & Tech Corp | Mixed GIP-based agonists for the treatment of metabolic diseases and obesity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879273A (en) * | 1987-05-22 | 1989-11-07 | The Rockefeller University | Glucagon homologs and therapeutic use thereof |
| EP0397834B1 (de) * | 1988-10-28 | 2000-02-02 | Genentech, Inc. | Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten |
-
1992
- 1992-01-14 CA CA002100874A patent/CA2100874A1/en not_active Abandoned
- 1992-01-14 WO PCT/US1992/000346 patent/WO1992012998A1/en not_active Ceased
- 1992-01-14 DK DK92904367.7T patent/DK0567562T3/da active
- 1992-01-14 ES ES92904367T patent/ES2085004T3/es not_active Expired - Lifetime
- 1992-01-14 AU AU12003/92A patent/AU663861B2/en not_active Ceased
- 1992-01-14 JP JP4504578A patent/JPH06504913A/ja active Pending
- 1992-01-14 AT AT92904367T patent/ATE135372T1/de not_active IP Right Cessation
- 1992-01-14 EP EP92904367A patent/EP0567562B1/de not_active Expired - Lifetime
- 1992-01-14 DE DE69209052T patent/DE69209052T2/de not_active Expired - Fee Related
-
1995
- 1995-09-06 AU AU30475/95A patent/AU673648B2/en not_active Ceased
-
1996
- 1996-04-19 GR GR960401050T patent/GR3019673T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992012998A1 (en) | 1992-08-06 |
| AU673648B2 (en) | 1996-11-14 |
| EP0567562A1 (de) | 1993-11-03 |
| JPH06504913A (ja) | 1994-06-09 |
| EP0567562B1 (de) | 1996-03-13 |
| AU1200392A (en) | 1992-08-27 |
| DK0567562T3 (da) | 1996-07-29 |
| ES2085004T3 (es) | 1996-05-16 |
| GR3019673T3 (en) | 1996-07-31 |
| DE69209052D1 (de) | 1996-04-18 |
| AU663861B2 (en) | 1995-10-26 |
| AU3047595A (en) | 1995-12-07 |
| DE69209052T2 (de) | 1996-11-14 |
| CA2100874A1 (en) | 1992-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |