ATE129018T1 - Zelluläres verfahren zur bestimmung des originalen gewebes. - Google Patents
Zelluläres verfahren zur bestimmung des originalen gewebes.Info
- Publication number
- ATE129018T1 ATE129018T1 AT87902883T AT87902883T ATE129018T1 AT E129018 T1 ATE129018 T1 AT E129018T1 AT 87902883 T AT87902883 T AT 87902883T AT 87902883 T AT87902883 T AT 87902883T AT E129018 T1 ATE129018 T1 AT E129018T1
- Authority
- AT
- Austria
- Prior art keywords
- tissue
- nuclear matrix
- procedure
- proteins
- cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 230000001413 cellular effect Effects 0.000 title abstract 2
- 102000008297 Nuclear Matrix-Associated Proteins Human genes 0.000 abstract 6
- 108010035916 Nuclear Matrix-Associated Proteins Proteins 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 5
- 210000001519 tissue Anatomy 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 210000000299 nuclear matrix Anatomy 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 210000001124 body fluid Anatomy 0.000 abstract 2
- 239000010839 body fluid Substances 0.000 abstract 2
- 230000005779 cell damage Effects 0.000 abstract 2
- 208000037887 cell injury Diseases 0.000 abstract 2
- 230000009395 genetic defect Effects 0.000 abstract 2
- 230000036210 malignancy Effects 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 238000002669 amniocentesis Methods 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000001574 biopsy Methods 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 210000005228 liver tissue Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/812,955 US4882268A (en) | 1985-12-24 | 1985-12-24 | Method for determining tissue of origin and degree of malignancy of tumor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE129018T1 true ATE129018T1 (de) | 1995-10-15 |
Family
ID=25211074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87902883T ATE129018T1 (de) | 1985-12-24 | 1986-12-23 | Zelluläres verfahren zur bestimmung des originalen gewebes. |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US4882268A (de) |
| EP (1) | EP0250589B1 (de) |
| JP (2) | JP2527777B2 (de) |
| AT (1) | ATE129018T1 (de) |
| DE (1) | DE3650416T2 (de) |
| WO (1) | WO1987003910A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE35747E (en) * | 1985-12-24 | 1998-03-17 | Massachusetts Institute Of Technology | Method for determining tissue of origin and presence and extent of cellular abnormalities |
| US5063162A (en) * | 1987-04-24 | 1991-11-05 | Hoffmann-La Roche Inc. | Process for isolating nucleic acids utilizing protease digestion |
| US5340935A (en) * | 1990-01-05 | 1994-08-23 | Dana-Farber Cancer Institute, Inc. | DNAS encoding proteins active in lymphocyte-medicated cytotoxicity |
| US5079343A (en) * | 1990-01-05 | 1992-01-07 | Dana-Farber Cancer Institute, Inc. | Intracellular antigen found in subpopulation of cd8+ t lymphocytes and monoclonal antibody reactive with same |
| US5318031A (en) * | 1990-07-23 | 1994-06-07 | Bruker Analytische Messtechnik Gmbh | Method and apparatus for determining chemical states of living animal or human tissue using nuclear magnetic resonance |
| JP3190042B2 (ja) * | 1991-10-31 | 2001-07-16 | マトリテク インコーポレイテッド | 核マトリックス蛋白液アッセー |
| US5324634A (en) * | 1992-03-31 | 1994-06-28 | The Research Foundation Of State University Of New York | Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer |
| DE69333377T2 (de) * | 1992-06-22 | 2004-10-21 | Matritech Inc | Neuartige marker maligner zelltypen in der inneren nukleären matrix |
| US6303297B1 (en) | 1992-07-17 | 2001-10-16 | Incyte Pharmaceuticals, Inc. | Database for storage and analysis of full-length sequences |
| WO1994003470A1 (en) * | 1992-08-10 | 1994-02-17 | Davies Richard J | Method and apparatus for screening and diagnosing for cancers |
| EP0684955B1 (de) * | 1993-02-09 | 2005-08-24 | The Johns Hopkins University School Of Medicine | Zellkernmatrixproteine |
| US5547928A (en) * | 1993-12-17 | 1996-08-20 | Matritech, Inc. | Methods and compositions for the detection of colon cancers |
| AUPM845694A0 (en) * | 1994-09-28 | 1994-10-20 | University Of Sydney, The | Identification of homologous genes across species boundaries |
| BR9607575A (pt) * | 1995-11-03 | 1998-12-15 | Robert R Bahnson | Proteínas matriz nuclear da bexiga e seu uso na detecção e tratamento dos distúrbios proliferativos celulares |
| US6280956B1 (en) | 1995-11-03 | 2001-08-28 | University Of Pittsburgh | Antibodies to bladder cancer nuclear matrix proteins and their use |
| US5914238A (en) | 1996-06-05 | 1999-06-22 | Matritech, Inc. | Materials and methods for detection of breast cancer |
| US5858683A (en) * | 1996-08-30 | 1999-01-12 | Matritech, Inc. | Methods and compositions for the detection of cervical cancer |
| US6232443B1 (en) | 1997-04-08 | 2001-05-15 | University Of Pittsburgh | Renal nuclear matrix proteins, polynucleotide sequences encoding them, and their use |
| US20020064792A1 (en) * | 1997-11-13 | 2002-05-30 | Lincoln Stephen E. | Database for storage and analysis of full-length sequences |
| US6617432B1 (en) * | 1999-10-15 | 2003-09-09 | University Of Pittsburgh | Nuclear matrix proteins polynucleotide sequences encoding them and their use |
| US20030228640A1 (en) * | 1999-10-15 | 2003-12-11 | University Of Pittsburgh | Nuclear matrix proteins, polynucleotide sequences encoding them, and their use |
| US6773894B1 (en) * | 2000-01-21 | 2004-08-10 | Biochain Institute, Inc. | Isolation and extraction of subcellularly compartmentalized protein |
| GB0022017D0 (en) * | 2000-09-08 | 2000-10-25 | Univ Dundee | Cell assays |
| US10941450B2 (en) | 2015-03-17 | 2021-03-09 | The Johns Hopkins University | Urothelial cancer and methods of detection and targeted therapy |
| KR102475710B1 (ko) * | 2016-07-22 | 2022-12-08 | 오레곤 헬스 앤드 사이언스 유니버시티 | 단일 세포 전체 게놈 라이브러리 및 이의 제조를 위한 조합 인덱싱 방법 |
| CA3090102A1 (en) * | 2018-01-31 | 2019-08-08 | Dovetail Genomics, Llc | Sample prep for dna linkage recovery |
| KR102640255B1 (ko) | 2018-05-17 | 2024-02-27 | 일루미나, 인코포레이티드 | 감소된 증폭 편향을 갖는 고속-대량 단일 세포 서열분석 |
| CN114341152B (zh) * | 2019-09-06 | 2025-06-13 | 赛多利斯比亚分离有限责任公司 | 用于降低生物制品的染色质含量的组合物和方法 |
| WO2024163959A2 (en) * | 2023-02-03 | 2024-08-08 | Talus Bioscience, Inc. | Extraction of nuclear and chromatin-bound proteins using volatile salts |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US4569916A (en) * | 1984-05-21 | 1986-02-11 | Massachusetts Institute Of Technology | Assay for tumor promoting agents |
-
1985
- 1985-12-24 US US06/812,955 patent/US4882268A/en not_active Expired - Lifetime
-
1986
- 1986-12-23 US US06/946,770 patent/US4885236A/en not_active Ceased
- 1986-12-23 DE DE3650416T patent/DE3650416T2/de not_active Expired - Lifetime
- 1986-12-23 WO PCT/US1986/002798 patent/WO1987003910A1/en not_active Ceased
- 1986-12-23 JP JP62501481A patent/JP2527777B2/ja not_active Expired - Lifetime
- 1986-12-23 AT AT87902883T patent/ATE129018T1/de not_active IP Right Cessation
- 1986-12-23 EP EP87902883A patent/EP0250589B1/de not_active Expired - Lifetime
-
1996
- 1996-02-08 JP JP8022895A patent/JP2675774B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3650416D1 (de) | 1995-11-16 |
| JP2527777B2 (ja) | 1996-08-28 |
| EP0250589A4 (en) | 1990-11-28 |
| JPS63502484A (ja) | 1988-09-22 |
| DE3650416T2 (de) | 1996-04-04 |
| US4882268A (en) | 1989-11-21 |
| US4885236A (en) | 1989-12-05 |
| EP0250589B1 (de) | 1995-10-11 |
| WO1987003910A1 (en) | 1987-07-02 |
| JPH08239400A (ja) | 1996-09-17 |
| EP0250589A1 (de) | 1988-01-07 |
| JP2675774B2 (ja) | 1997-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |