ATE128122T1 - 9-substituierte bicyclo (3.3.0>octan-derivate verwendbar als txa2-antagonisten. - Google Patents
9-substituierte bicyclo (3.3.0>octan-derivate verwendbar als txa2-antagonisten.Info
- Publication number
- ATE128122T1 ATE128122T1 AT92922093T AT92922093T ATE128122T1 AT E128122 T1 ATE128122 T1 AT E128122T1 AT 92922093 T AT92922093 T AT 92922093T AT 92922093 T AT92922093 T AT 92922093T AT E128122 T1 ATE128122 T1 AT E128122T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- substituted bicyclo
- octane derivatives
- derivatives usable
- txa2 antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- AEBWATHAIVJLTA-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydropentalene Chemical class C1CCC2CCCC21 AEBWATHAIVJLTA-UHFFFAOYSA-N 0.000 abstract 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 abstract 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 abstract 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Steroid Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4134156A DE4134156A1 (de) | 1991-10-11 | 1991-10-11 | 9-substituierte bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE128122T1 true ATE128122T1 (de) | 1995-10-15 |
Family
ID=6442746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92922093T ATE128122T1 (de) | 1991-10-11 | 1992-10-09 | 9-substituierte bicyclo (3.3.0>octan-derivate verwendbar als txa2-antagonisten. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5405988A (fr) |
| EP (1) | EP0563358B1 (fr) |
| JP (1) | JPH06505506A (fr) |
| AT (1) | ATE128122T1 (fr) |
| CA (1) | CA2097930A1 (fr) |
| DE (2) | DE4134156A1 (fr) |
| PT (1) | PT100950A (fr) |
| WO (1) | WO1993007118A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001296536A1 (en) * | 2000-10-03 | 2002-04-15 | University Of Virginian Patent Foundation | Novel lysophosphatidic acid receptor agonists and antagonists |
| EP1383778B1 (fr) | 2001-01-30 | 2009-10-21 | University Of Virginia Patent Foundation | Agonistes et antagonistes de recepteurs de sphingosine-1-phosphate |
| CA2533587A1 (fr) * | 2002-07-30 | 2004-02-05 | University Of Virginia Patent Foundation | Composes actifs dans la signalisation de sphingosine 1-phosphate |
| US7638637B2 (en) * | 2003-11-03 | 2009-12-29 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| EP1750722A4 (fr) * | 2004-05-06 | 2010-03-10 | Univ Virginia | Nouveaux antagonistes selectifs du recepteur de l'acide lysophosphatidique |
| MX2007006706A (es) * | 2004-12-06 | 2007-10-18 | Univ Virginia | Analogos de esfingosina 1-fosfato amida de arilo. |
| WO2006088944A1 (fr) | 2005-02-14 | 2006-08-24 | University Of Virginia Patent Foundation | Agonistes de sphingosine-1-phosphate comportant des cycloalcanes et heterocycles substitues par des groupes amino et phenyle |
| RU2008134702A (ru) * | 2006-01-27 | 2010-03-10 | Юниверсити Оф Вирждиния Пэтент Фаундейшн (Us) | Способ лечения невропатической боли |
| WO2007092638A1 (fr) * | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Analogues de sphingosine 1-phosphate bicyclique |
| JP2010510249A (ja) * | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸アゴニスト活性を有するテトラリンアナログ |
| WO2008064337A2 (fr) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Analogues benzocycloheptyle ayant une activité de récepteur de sphingosine 1-phosphate |
| EP2099741A2 (fr) * | 2006-11-21 | 2009-09-16 | University Of Virginia Patent Foundation | Analogues d'hydrindane ayant une activité agoniste de récepteur de sphingosine-1-phosphate |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588823A (en) * | 1982-02-16 | 1986-05-13 | The Upjohn Company | 9-substituted carbacyclin analogs |
| US4487961A (en) * | 1982-02-16 | 1984-12-11 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| DE3428266A1 (de) * | 1984-07-27 | 1986-01-30 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4971987A (en) * | 1984-07-27 | 1990-11-20 | Schering Aktiengesellschaft | New carbacycline, process for their production and their use as a drug |
| DE3542745A1 (de) * | 1985-11-29 | 1987-08-06 | Schering Ag | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3725031A1 (de) * | 1987-07-24 | 1989-02-02 | Schering Ag | Neue 9-substituierte carbacyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1991
- 1991-10-11 DE DE4134156A patent/DE4134156A1/de not_active Withdrawn
-
1992
- 1992-10-09 CA CA002097930A patent/CA2097930A1/fr not_active Abandoned
- 1992-10-09 AT AT92922093T patent/ATE128122T1/de not_active IP Right Cessation
- 1992-10-09 PT PT100950A patent/PT100950A/pt not_active Application Discontinuation
- 1992-10-09 US US08/074,868 patent/US5405988A/en not_active Expired - Fee Related
- 1992-10-09 EP EP92922093A patent/EP0563358B1/fr not_active Expired - Lifetime
- 1992-10-09 JP JP5506549A patent/JPH06505506A/ja active Pending
- 1992-10-09 WO PCT/DE1992/000865 patent/WO1993007118A1/fr active IP Right Grant
- 1992-10-09 DE DE59203771T patent/DE59203771D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5405988A (en) | 1995-04-11 |
| EP0563358A1 (fr) | 1993-10-06 |
| PT100950A (pt) | 1993-11-30 |
| CA2097930A1 (fr) | 1993-04-12 |
| DE4134156A1 (de) | 1993-04-15 |
| WO1993007118A1 (fr) | 1993-04-15 |
| DE59203771D1 (de) | 1995-10-26 |
| JPH06505506A (ja) | 1994-06-23 |
| EP0563358B1 (fr) | 1995-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |