ATE123767T1 - 24-cyclopropan-vitamin-d-derivate. - Google Patents
24-cyclopropan-vitamin-d-derivate.Info
- Publication number
- ATE123767T1 ATE123767T1 AT93305347T AT93305347T ATE123767T1 AT E123767 T1 ATE123767 T1 AT E123767T1 AT 93305347 T AT93305347 T AT 93305347T AT 93305347 T AT93305347 T AT 93305347T AT E123767 T1 ATE123767 T1 AT E123767T1
- Authority
- AT
- Austria
- Prior art keywords
- vitamin
- alpha
- activity
- derivatives
- compounds
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/910,423 US5194431A (en) | 1992-07-08 | 1992-07-08 | 24-cyclopropane vitamin D derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE123767T1 true ATE123767T1 (de) | 1995-06-15 |
Family
ID=25428763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93305347T ATE123767T1 (de) | 1992-07-08 | 1993-07-08 | 24-cyclopropan-vitamin-d-derivate. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5194431A (de) |
| EP (1) | EP0578494B1 (de) |
| JP (1) | JP3253425B2 (de) |
| KR (1) | KR100273182B1 (de) |
| AT (1) | ATE123767T1 (de) |
| AU (1) | AU659745B2 (de) |
| DE (1) | DE69300196T2 (de) |
| IL (1) | IL106167A (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| IL99368A (en) * | 1991-09-02 | 1996-01-19 | Teva Pharma | Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine |
| DE4220757A1 (de) * | 1992-06-24 | 1994-01-05 | Schering Ag | Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
| GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| US5401733A (en) * | 1993-10-01 | 1995-03-28 | Hoffmann-La Roche Inc. | Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol |
| US5373004A (en) * | 1993-11-24 | 1994-12-13 | Wisconsin Alumni Research Foundation | 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds |
| ZA95906B (en) * | 1994-02-07 | 1996-08-06 | Res Developments Foundation | Non-viral vector |
| IT1311922B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1319201B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2003087048A2 (en) * | 2002-04-11 | 2003-10-23 | Instytut Farmaceutyczny | Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds |
| NZ545270A (en) * | 2003-07-30 | 2010-04-30 | Rigel Pharmaceuticals Inc | 2,4-Pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| CA2607901C (en) | 2005-06-13 | 2016-08-16 | Rigel Pharmaceuticals, Inc. | Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine |
| PL1734251T3 (pl) * | 2005-06-17 | 2007-05-31 | Magneti Marelli Powertrain Spa | Wtryskiwacz paliwa |
| CN102341110B (zh) | 2009-01-27 | 2017-04-12 | 博格有限责任公司 | 用于减轻与化疗有关的副作用的维生素d3及其类似物 |
| IN2012DN02137A (de) | 2009-08-14 | 2015-08-07 | Berg Biosystems Llc | |
| EP2515866B1 (de) * | 2009-12-22 | 2014-02-19 | Leo Pharma A/S | Pharmazeutische zusammensetzung mit einer lösungsmittelmischung und einem vitamin-d-derivat oder -analogon |
| JP6055314B2 (ja) | 2013-01-10 | 2016-12-27 | 理想科学工業株式会社 | 給紙装置 |
| AU2014274099A1 (en) | 2013-05-29 | 2015-12-24 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin D |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3833622A (en) * | 1969-03-17 | 1974-09-03 | Upjohn Co | Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds |
| US3901928A (en) * | 1973-01-10 | 1975-08-26 | Robert Henry Hesse | 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds |
| US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
| US4255596A (en) | 1980-02-25 | 1981-03-10 | Gulf Research & Development Company | Preparation of ethylene glycol from ethylene |
| US4769181A (en) * | 1983-11-07 | 1988-09-06 | Wisconsin Alumni Research Foundation | 1,25-dihydroxyvitamin D2 compounds |
| US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
| DE3881665T2 (de) | 1987-03-30 | 1993-10-07 | Kuraray Co | Pregnanabkömmlinge und verfahren zur herstellung. |
| JP2608322B2 (ja) * | 1988-04-11 | 1997-05-07 | 日清製粉株式会社 | １α，２５‐ジヒドロキシビタミンＤ▲下２▼類の製造法 |
| JP2711161B2 (ja) * | 1988-04-21 | 1998-02-10 | レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ／エス（レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ） | 新規ビタミンｄ類似体 |
| US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
| US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
| US4928065A (en) * | 1989-03-31 | 1990-05-22 | E. I. Du Pont De Nemours And Company | Voltammetry in low-permitivity suspensions |
| JP2645130B2 (ja) * | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
-
1992
- 1992-07-08 US US07/910,423 patent/US5194431A/en not_active Expired - Lifetime
-
1993
- 1993-06-29 IL IL10616793A patent/IL106167A/en not_active IP Right Cessation
- 1993-07-07 JP JP19180793A patent/JP3253425B2/ja not_active Expired - Fee Related
- 1993-07-07 KR KR1019930012709A patent/KR100273182B1/ko not_active Expired - Fee Related
- 1993-07-07 AU AU41817/93A patent/AU659745B2/en not_active Ceased
- 1993-07-08 DE DE69300196T patent/DE69300196T2/de not_active Expired - Fee Related
- 1993-07-08 AT AT93305347T patent/ATE123767T1/de not_active IP Right Cessation
- 1993-07-08 EP EP93305347A patent/EP0578494B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5194431A (en) | 1993-03-16 |
| EP0578494A1 (de) | 1994-01-12 |
| JPH0672995A (ja) | 1994-03-15 |
| JP3253425B2 (ja) | 2002-02-04 |
| AU4181793A (en) | 1994-01-13 |
| KR940002210A (ko) | 1994-02-16 |
| DE69300196D1 (de) | 1995-07-20 |
| EP0578494B1 (de) | 1995-06-14 |
| IL106167A0 (en) | 1993-10-20 |
| AU659745B2 (en) | 1995-05-25 |
| IL106167A (en) | 1998-08-16 |
| KR100273182B1 (ko) | 2000-12-01 |
| DE69300196T2 (de) | 1995-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |