ATE12117T1 - Durch purinbasen substituierte 1.4;3.6-dianhydro- hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung. - Google Patents
Durch purinbasen substituierte 1.4;3.6-dianhydro- hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung.Info
- Publication number
- ATE12117T1 ATE12117T1 AT81104476T AT81104476T ATE12117T1 AT E12117 T1 ATE12117 T1 AT E12117T1 AT 81104476 T AT81104476 T AT 81104476T AT 81104476 T AT81104476 T AT 81104476T AT E12117 T1 ATE12117 T1 AT E12117T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- nitrates
- atoms
- purine bases
- desoxy
- Prior art date
Links
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000002823 nitrates Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 methyl-substituted monocarboxylic acid Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803028273 DE3028273A1 (de) | 1980-07-25 | 1980-07-25 | Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate |
| EP81104476A EP0044928B1 (de) | 1980-07-25 | 1981-06-11 | Durch Purinbasen substituierte 1.4;3.6-Dianhydro-hexit-nitrate, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE12117T1 true ATE12117T1 (de) | 1985-03-15 |
Family
ID=6108126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT81104476T ATE12117T1 (de) | 1980-07-25 | 1981-06-11 | Durch purinbasen substituierte 1.4;3.6-dianhydro- hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US4479951A (en, 2012) |
| EP (1) | EP0044928B1 (en, 2012) |
| JP (1) | JPS5764700A (en, 2012) |
| AT (1) | ATE12117T1 (en, 2012) |
| CA (1) | CA1190544A (en, 2012) |
| DE (1) | DE3028273A1 (en, 2012) |
| ES (1) | ES8204994A1 (en, 2012) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3028288A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung |
| JPS6094992A (ja) * | 1983-10-28 | 1985-05-28 | Sankyo Co Ltd | グリゼオ−ル酸誘導体 |
| DE3421072A1 (de) * | 1984-06-06 | 1985-12-12 | Heinrich Mack Nachf., 7918 Illertissen | 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3843117A1 (de) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | Neue xanthinderivate mit adenosin-antagonistischer wirkung |
| CA2014520C (en) * | 1989-04-17 | 1996-07-16 | Fumio Suzuki | Hexitol derivatives |
| DE59208572D1 (de) * | 1991-10-17 | 1997-07-10 | Ciba Geigy Ag | Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte |
| WO1994002497A1 (en) * | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sulfo-derivatives of adenosine |
| AU683287B2 (en) | 1993-07-23 | 1997-11-06 | Merrell Pharmaceuticals Inc. | Novel 9-N-bicyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines |
| US5994361A (en) * | 1994-06-22 | 1999-11-30 | Biochem Pharma | Substituted purinyl derivatives with immunomodulating activity |
| US5786360A (en) | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| EP1601649A4 (en) * | 2003-02-19 | 2009-03-04 | Endacea Inc | A1-adenosine receptor antagonistic |
| CA2528385C (en) * | 2003-06-06 | 2011-03-15 | Endacea, Inc. | A1 adenosine receptor antogonists |
| CA2528367A1 (en) * | 2003-06-09 | 2004-12-23 | Endacea, Inc. | A1 adenosine receptor antagonists |
| US8127691B2 (en) * | 2004-03-03 | 2012-03-06 | Fitzpatrick Technologies, Llc | SMC pallet |
| US20060081158A1 (en) * | 2004-10-19 | 2006-04-20 | Fitzpatrick Technologies, L.L.C. | Pultrusion pallet |
| US20070017422A1 (en) * | 2005-07-19 | 2007-01-25 | Fitzpatrick Technologies, Llc | Pallet with composite components |
| US20070017423A1 (en) * | 2005-07-19 | 2007-01-25 | Ingham Terry L | Pallet With Recycled Components |
| WO2009042872A1 (en) * | 2007-09-26 | 2009-04-02 | Fitzpatrick Technologies | Pallet with lead board |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852506A (en) * | 1955-10-31 | 1958-09-16 | American Cyanamid Co | Method of preparing aminodeoxyglycosidopurines |
| US3886186A (en) * | 1971-04-29 | 1975-05-27 | American Home Prod | Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol |
| US4000137A (en) * | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
| US4087603A (en) * | 1976-09-27 | 1978-05-02 | Eli Lilly And Company | Antifungal antibiotics |
| US4065488A (en) * | 1977-02-24 | 1977-12-27 | American Home Products Corporation | Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate |
| JPS55113786A (en) * | 1979-02-23 | 1980-09-02 | Toyo Jozo Co Ltd | Novel substance, nepranosin b or f and its preparation |
| IL59664A0 (en) * | 1979-04-05 | 1980-06-30 | Wuelfing J Kg | Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions |
| DE3028272A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung |
-
1980
- 1980-07-25 DE DE19803028273 patent/DE3028273A1/de active Granted
-
1981
- 1981-06-11 EP EP81104476A patent/EP0044928B1/de not_active Expired
- 1981-06-11 AT AT81104476T patent/ATE12117T1/de not_active IP Right Cessation
- 1981-06-29 ES ES503486A patent/ES8204994A1/es not_active Expired
- 1981-07-08 CA CA000381368A patent/CA1190544A/en not_active Expired
- 1981-07-20 US US06/285,406 patent/US4479951A/en not_active Expired - Fee Related
- 1981-07-24 JP JP56116321A patent/JPS5764700A/ja active Granted
-
1984
- 1984-08-17 US US06/642,140 patent/US4622324A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0044928B1 (de) | 1985-03-13 |
| JPH0247476B2 (en, 2012) | 1990-10-19 |
| DE3028273C2 (en, 2012) | 1989-12-14 |
| DE3028273A1 (de) | 1982-02-25 |
| JPS5764700A (en) | 1982-04-19 |
| US4479951A (en) | 1984-10-30 |
| ES503486A0 (es) | 1982-05-16 |
| EP0044928A1 (de) | 1982-02-03 |
| CA1190544A (en) | 1985-07-16 |
| ES8204994A1 (es) | 1982-05-16 |
| US4622324A (en) | 1986-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |