ATE116442T1 - Verfahren zum formen und zum gebrauch von mikrotröpchen. - Google Patents

Verfahren zum formen und zum gebrauch von mikrotröpchen.

Info

Publication number
ATE116442T1
ATE116442T1 AT89905521T AT89905521T ATE116442T1 AT E116442 T1 ATE116442 T1 AT E116442T1 AT 89905521 T AT89905521 T AT 89905521T AT 89905521 T AT89905521 T AT 89905521T AT E116442 T1 ATE116442 T1 AT E116442T1
Authority
AT
Austria
Prior art keywords
microdroplets
gel
disclosed
aqueous
biological entities
Prior art date
Application number
AT89905521T
Other languages
English (en)
Inventor
James C Weaver
Gregory B Williams
Jonathan G Bliss
Kevin T Powell
Gail I Harrison
Julian Joseph
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/185,083 external-priority patent/US4959301A/en
Priority claimed from US07/184,969 external-priority patent/US5225332A/en
Priority claimed from US07/185,156 external-priority patent/US5055390A/en
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE116442T1 publication Critical patent/ATE116442T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
AT89905521T 1988-04-22 1989-04-21 Verfahren zum formen und zum gebrauch von mikrotröpchen. ATE116442T1 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US18508488A 1988-04-22 1988-04-22
US18513688A 1988-04-22 1988-04-22
US18547588A 1988-04-22 1988-04-22
US18516088A 1988-04-22 1988-04-22
US18496888A 1988-04-22 1988-04-22
US07/185,083 US4959301A (en) 1988-04-22 1988-04-22 Process for rapidly enumerating viable entities
US07/184,969 US5225332A (en) 1988-04-22 1988-04-22 Process for manipulation of non-aqueous surrounded microdroplets
US07/185,156 US5055390A (en) 1988-04-22 1988-04-22 Process for chemical manipulation of non-aqueous surrounded microdroplets

Publications (1)

Publication Number Publication Date
ATE116442T1 true ATE116442T1 (de) 1995-01-15

Family

ID=27575103

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89905521T ATE116442T1 (de) 1988-04-22 1989-04-21 Verfahren zum formen und zum gebrauch von mikrotröpchen.

Country Status (6)

Country Link
EP (1) EP0411038B1 (de)
JP (1) JPH03503845A (de)
AT (1) ATE116442T1 (de)
AU (1) AU3556789A (de)
DE (1) DE68920319D1 (de)
WO (1) WO1989010566A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717476B1 (fr) * 1994-03-16 1996-04-19 Rhone Poulenc Chimie Sphérules de coumarine et/ou dérivés et leur procédé d'obtention.
ES2103195B1 (es) * 1995-06-22 1998-03-01 Univ Pais Vasco Procedimiento para la produccion de vesiculas de membrana plasmatica de hongos y levaduras con orientacion controlada.
WO1999064560A1 (en) * 1998-06-08 1999-12-16 Basf Aktiengesellschaft Methods for monitoring the stability of protein or cellular product secretion by cells in a fermenter culture
GB2341610B (en) * 1998-09-17 2003-12-03 Guinness Ltd Method of calculating amounts of yeast for use in a process
GB0002539D0 (en) * 2000-02-03 2000-03-29 Lonza Biologics Plc Process for the discrimination of immunoglobulin G-producing cells from non-immunoglobulin G-producing cells
EP1356037B1 (de) 2001-01-25 2011-03-09 Evolva Ltd. Zellbibliothek
US8008459B2 (en) 2001-01-25 2011-08-30 Evolva Sa Concatemers of differentially expressed multiple genes
US7026166B2 (en) * 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US7704756B2 (en) 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
WO2004069849A2 (en) 2003-01-29 2004-08-19 454 Corporation Bead emulsion nucleic acid amplification
WO2005027714A2 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
CA2553833C (en) * 2004-01-28 2012-10-02 454 Corporation Nucleic acid amplification with continuous flow emulsion
US8277867B2 (en) 2007-09-14 2012-10-02 Boston Scientific Scimed, Inc. Microdrop ablumenal coating system and method
AT509355B1 (de) 2010-02-10 2012-04-15 Univ Graz Tech Testanordnung
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
US20150177115A1 (en) 2012-04-06 2015-06-25 Slingshot Biosciences Hydrogel particles with tunable optical properties
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
WO2014198994A1 (es) * 2013-06-13 2014-12-18 Biomedal, S.L. Método para el análisis rápido de actividad celular
KR20230141834A (ko) 2015-02-09 2023-10-10 슬링샷 바이오사이언시즈 인코포레이티드 튜닝가능한 광 특성을 갖는 하이드로겔 입자 및 이를 사용하기 위한 방법
EP3278115A2 (de) 2015-03-30 2018-02-07 Accelerate Diagnostics, Inc. Instrument und system zum schnellen identifizieren von mikroorganismen und testen der antimikrobiellen wirkstoffempfindlichkeit
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
WO2017130059A1 (en) 2016-01-25 2017-08-03 Bio-Rad Innovations Digital microbiology
CN112789350A (zh) * 2018-08-17 2021-05-11 贝克顿·迪金森公司 利用微滴的抗微生物剂敏感性测试
CN114174799A (zh) * 2019-05-30 2022-03-11 贝克曼库尔特有限公司 用于固定生物标本以进行显微成像的方法和系统
TW202141019A (zh) 2020-01-24 2021-11-01 美商史林夏特生化公司 類細胞校正粒子之組合物與方法
CN115485556A (zh) 2020-05-04 2022-12-16 弹弓生物科学公司 用于多路复用测定的被动光学条形码化的组合物和方法
CN112070999B (zh) * 2020-08-11 2022-05-31 上海工程技术大学 一种地下管网保护警示牌及其振动信号识别方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401755A (en) * 1981-01-29 1983-08-30 Massachusetts Institute Of Technology Process for measuring microbiologically active material
EP0109861A3 (de) * 1982-11-23 1986-05-14 Bio-Response Inc. Verfahren zum Absondern von Zellen
ZA84232B (en) * 1983-01-21 1984-11-28 Bio Response Inc Isolation and culture of mammalian cells secreting acetylcholinesterase and recovering of acetylcholinesterase therefrom
US4649109A (en) * 1984-02-16 1987-03-10 Brandeis University Methods for isolating mutant microorganisms from parental populations

Also Published As

Publication number Publication date
EP0411038B1 (de) 1994-12-28
AU3556789A (en) 1989-11-24
EP0411038A1 (de) 1991-02-06
DE68920319D1 (de) 1995-02-09
JPH03503845A (ja) 1991-08-29
WO1989010566A1 (en) 1989-11-02

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