ATE114970T1 - NON-ABSORBABLE CHOLESTEROL ESTERASE INHIBITORS TO REDUCE CHOLESTEROL ABSORPTION. - Google Patents

NON-ABSORBABLE CHOLESTEROL ESTERASE INHIBITORS TO REDUCE CHOLESTEROL ABSORPTION.

Info

Publication number
ATE114970T1
ATE114970T1 AT90907923T AT90907923T ATE114970T1 AT E114970 T1 ATE114970 T1 AT E114970T1 AT 90907923 T AT90907923 T AT 90907923T AT 90907923 T AT90907923 T AT 90907923T AT E114970 T1 ATE114970 T1 AT E114970T1
Authority
AT
Austria
Prior art keywords
cholesterol
absorbable
esterase inhibitors
reduce
absorption
Prior art date
Application number
AT90907923T
Other languages
German (de)
Inventor
Louis George Lange Iii
Curtis A Spilburg
Original Assignee
Louis George Lange Iii
Curtis A Spilburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/340,868 external-priority patent/US5017565A/en
Application filed by Louis George Lange Iii, Curtis A Spilburg filed Critical Louis George Lange Iii
Application granted granted Critical
Publication of ATE114970T1 publication Critical patent/ATE114970T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

This invention encompasses a method and compositions which inhibit pancreatic cholesterol esterase and triglyceride lipase and hence, lower cholesterol and triglycerides in the blood stream.
AT90907923T 1989-04-20 1990-04-20 NON-ABSORBABLE CHOLESTEROL ESTERASE INHIBITORS TO REDUCE CHOLESTEROL ABSORPTION. ATE114970T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/340,868 US5017565A (en) 1989-04-20 1989-04-20 Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
US07/429,398 US5063210A (en) 1989-04-20 1989-10-31 Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption

Publications (1)

Publication Number Publication Date
ATE114970T1 true ATE114970T1 (en) 1994-12-15

Family

ID=26992276

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90907923T ATE114970T1 (en) 1989-04-20 1990-04-20 NON-ABSORBABLE CHOLESTEROL ESTERASE INHIBITORS TO REDUCE CHOLESTEROL ABSORPTION.

Country Status (10)

Country Link
US (1) US5063210A (en)
EP (1) EP0469079B1 (en)
JP (1) JPH0819001B2 (en)
AT (1) ATE114970T1 (en)
AU (1) AU633569B2 (en)
CA (1) CA2053258C (en)
DE (1) DE69014870T2 (en)
DK (1) DK0469079T3 (en)
ES (1) ES2064736T3 (en)
WO (1) WO1990012579A1 (en)

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AU3434889A (en) * 1988-03-15 1989-10-05 Jewish Hospital Of St. Louis, The Inhibition of intestinal cholesterol and fatty acid absorption
US5519010A (en) * 1989-02-06 1996-05-21 Taiho Pharmaceutical Co., Ltd. Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component
US5173408A (en) * 1989-11-13 1992-12-22 Lange Louis George Iii Mammalian pancreatic cholesterol esterase
DE4011285A1 (en) * 1990-04-06 1991-10-10 Steigerwald Arzneimittelwerk MEDICINES FOR TREATING HYPERLIPIDAEMIA AND / OR ATHEROSCLEROSIS
US5616570A (en) * 1991-10-18 1997-04-01 Lange, Iii; Louis G. Use of non-absorbable synthetic sulfated polysaccharides to decrease cholesterol absorbtion
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor
WO1995003058A1 (en) * 1993-07-21 1995-02-02 Belorussky Nauchno-Issledovatelsky Institut Kardiologii Oxidized starch derivatives as anti-aggregation, anticoagulant and anti-arrhythmic agents
SK67096A3 (en) * 1993-12-23 1997-06-04 Vianova Kunstharz Ag Process for preparing water-dilutable, acrylate copolymer-based lacquer binders, and their use
WO1996009827A2 (en) * 1994-09-20 1996-04-04 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
US7071174B1 (en) 1994-10-13 2006-07-04 Cv Therapeutics, Inc. Method and composition for inhibiting cholesterol esterase
CA2160440C (en) 1994-10-13 1998-08-25 Louis G. Lange, Iii Method of manufacturing non-absorbable synthetic sulfated polysaccharides
US5681819A (en) * 1994-12-01 1997-10-28 Oklahoma Medical Research Foundation Method and compositions for reducing cholesterol absorption
US5696087A (en) * 1994-12-01 1997-12-09 Oklahoma Medical Research Foundation Method and compositions for reducing cholesterol absorption
US5821226A (en) * 1994-12-01 1998-10-13 Oklahoma Medical Research Foundation BAL C-tail drug delivery molecules
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
US6342218B1 (en) 1997-02-14 2002-01-29 Oklahoma Medical Research Foundation Method for treatment of SLE
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
JPH11349485A (en) * 1998-06-09 1999-12-21 Shirako Co Ltd Improver of hepatic damage
TR200100472T2 (en) * 1998-08-14 2001-07-23 F.Hoffmann-La Roche Ag Pharmaceutical compositions containing lipase inhibitors and cytosan
US6462029B1 (en) * 1999-02-23 2002-10-08 Econugenics Compositions and methods for treating mammals with modified alginates and modified pectins
AU774958B2 (en) * 1999-10-02 2004-07-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Fibroblast growth factor-5 (FGF-5) is a tumor associated T-cell antigen
JP4601100B2 (en) * 1999-11-08 2010-12-22 三生医薬株式会社 Soft capsule containing mastic oil
DK1307263T3 (en) * 2000-07-28 2005-08-22 Hoffmann La Roche Hitherto unknown use of lipase inhibitors
PT1307264E (en) * 2000-07-28 2005-02-28 Hoffmann La Roche NEW PHARMACEUTICAL COMPOSITION
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US6946151B2 (en) * 2002-11-12 2005-09-20 Ayurvedic-Life International, Llc Therapeutic compositions
US6949261B2 (en) 2002-11-12 2005-09-27 Ayurvedic-Life International, Llc Compositions for diabetes treatment and prophylaxis
ES2251289B1 (en) 2004-02-27 2007-07-01 Bioiberica, S.A. NEW THERAPEUTIC USE OF A GROUP OF SULFATED POLYSACARIDS.
EP2123266B1 (en) * 2006-12-06 2014-01-15 Kaneka Corporation Cancer therapeutic agent and anti-carcinogenic agent
DE102007035322B4 (en) * 2007-07-25 2011-11-17 Friedrich-Schiller-Universität Jena Process for the preparation of water-soluble, low-substituted cellulose sulfates
US20100324075A1 (en) * 2007-12-21 2010-12-23 University Of Cincinnati Therapeutic use of carboxyl ester lipase inhibitors
US8022347B2 (en) * 2008-06-23 2011-09-20 Ricoh Company, Ltd. Optical scanning device, image forming apparatus, and optical scanning method having a plurality of light intensity control devices with a switching unit
GB0920633D0 (en) 2009-11-25 2010-01-13 Rdbiomed Ltd Inhibition of pancreatic lipase
WO2013166431A1 (en) 2012-05-03 2013-11-07 Beth Isreal Deaconess Medical Center, Inc. Lipids that increase insulin sensitivity and methods of using the same
WO2014144777A2 (en) 2013-03-15 2014-09-18 Beth Israel Deaconess Medical Center, Inc. Lipids that increase insulin sensitivity and methods of using the same

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Also Published As

Publication number Publication date
WO1990012579A1 (en) 1990-11-01
CA2053258C (en) 1998-02-10
ES2064736T3 (en) 1995-02-01
DE69014870T2 (en) 1995-04-27
CA2053258A1 (en) 1990-10-21
JPH04503813A (en) 1992-07-09
EP0469079A1 (en) 1992-02-05
US5063210A (en) 1991-11-05
AU5535690A (en) 1990-11-16
JPH0819001B2 (en) 1996-02-28
DK0469079T3 (en) 1995-07-10
DE69014870D1 (en) 1995-01-19
EP0469079B1 (en) 1994-12-07
AU633569B2 (en) 1993-02-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time