GB871590A - Water soluble antilipemic salts of sulphated polysaccharides - Google Patents
Water soluble antilipemic salts of sulphated polysaccharidesInfo
- Publication number
- GB871590A GB871590A GB31154/58A GB3115458A GB871590A GB 871590 A GB871590 A GB 871590A GB 31154/58 A GB31154/58 A GB 31154/58A GB 3115458 A GB3115458 A GB 3115458A GB 871590 A GB871590 A GB 871590A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salt
- sulphated
- alkali
- water
- average
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/02—Esters
- C08B31/06—Esters of inorganic acids
- C08B31/063—Starch sulfates
Landscapes
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The invention comprises a water-soluble salt of sulphated corn syrup solids or sulphated corn starch dextrin containing an average of 5-15 glucose units per molecule joined predominantly by alpha 1 : 4 and alpha 1 : 6 linkages and containing about 1,5-3 sulphate groups per glucose unit. These products are made by sulphating corn syrup solids or corn starch dextrin containing an average of between 1 and 20 glucose units per molecule with chlorosulphonic acid in the presence of a pyridine base, such as pyridine, picolines or mixtures thereof, preferably under anhydrous conditions and at temperatures below 55 DEG C. for not more than 6 hours, forming a water-soluble salt, e.g. by neutralizing with sodium or potassium hydroxide, and precipitating a fraction of said salt containing an average of between 5 and 15 glucose units per molecule and between 1,5 and 3 sulphate groups per glucose unit. Preferably the corn syrup solids or corn starch dextrin is fractionated either before or after sulphation, or both, so that the final product contains an average of between 5 and 15 glucose units per molecule. After fractionation the sulphated product may be treated with a water-miscible neutral oxygen-containing organic liquid to precipitate the pyridine salt of the sulphated polysaccharide. The latter is redissolved in water, neutralized with alkali and the alkali salt of the sulphated polysaccharide is precipitated by adding an alkanol of 1-3 carbon atoms or acetone, or an inorganic salt of the alkali, e.g. potassium chloride. Alternatively the sulphated product is added to water, the quantity of which is calculated to produce a saturated solution of the inorganic salts formed on subsequent neutralization with the calculated quantity of alkali so that the alkali salt of the sulphated polysaccharide separates. Fractionation of the corn starch dextrins or corn syrup solids before sulphation may be effected by refluxing with a mixture of formamide and methanol, by using chromatography on a cellulose column or by dialysis. Fractionation after sulphation may be effected with varying concentration of alcohols, or acetone, or salt solutions such as potassium chloride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US871590XA | 1958-08-18 | 1958-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB871590A true GB871590A (en) | 1961-06-28 |
Family
ID=22203453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31154/58A Expired GB871590A (en) | 1958-08-18 | 1958-09-30 | Water soluble antilipemic salts of sulphated polysaccharides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB871590A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
| EP0438903A2 (en) * | 1990-01-25 | 1991-07-31 | M.L. Laboratories Plc | Treatment of poisoning and compositions for use therein |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| US6632801B1 (en) | 1994-10-13 | 2003-10-14 | Cv Therapeutics, Inc. | Method and composition for inhibiting human cholesterol esterase |
-
1958
- 1958-09-30 GB GB31154/58A patent/GB871590A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5017565A (en) * | 1989-04-20 | 1991-05-21 | Lange Iii Louis G | Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| EP0438903A2 (en) * | 1990-01-25 | 1991-07-31 | M.L. Laboratories Plc | Treatment of poisoning and compositions for use therein |
| EP0438903A3 (en) * | 1990-01-25 | 1992-05-06 | M.L. Laboratories Plc | Treatment of poisoning and compositions for use therein |
| US6632801B1 (en) | 1994-10-13 | 2003-10-14 | Cv Therapeutics, Inc. | Method and composition for inhibiting human cholesterol esterase |
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