ATE114311T1 - Bivalente liganden, wirksam für die blockierung des enzyms acat. - Google Patents
Bivalente liganden, wirksam für die blockierung des enzyms acat.Info
- Publication number
- ATE114311T1 ATE114311T1 AT89907579T AT89907579T ATE114311T1 AT E114311 T1 ATE114311 T1 AT E114311T1 AT 89907579 T AT89907579 T AT 89907579T AT 89907579 T AT89907579 T AT 89907579T AT E114311 T1 ATE114311 T1 AT E114311T1
- Authority
- AT
- Austria
- Prior art keywords
- blocking
- bivalent ligands
- acat
- ligands effective
- enzyme acat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23293188A | 1988-08-16 | 1988-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE114311T1 true ATE114311T1 (de) | 1994-12-15 |
Family
ID=22875168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89907579T ATE114311T1 (de) | 1988-08-16 | 1989-06-16 | Bivalente liganden, wirksam für die blockierung des enzyms acat. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0429464B1 (de) |
JP (1) | JPH04500506A (de) |
KR (1) | KR900701792A (de) |
AT (1) | ATE114311T1 (de) |
DE (1) | DE68919475T2 (de) |
DK (1) | DK25691D0 (de) |
WO (1) | WO1990002129A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180717A (en) * | 1988-08-16 | 1993-01-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
US5304548A (en) * | 1988-08-16 | 1994-04-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
AU2291195A (en) * | 1994-04-12 | 1995-10-30 | Qualcomm Incorporated | Method and apparatus for freight transportation using a satellite navigation system |
US20100234363A1 (en) * | 2007-09-19 | 2010-09-16 | Institute Of Medicinal Molecular Design, Inc. | Heterocyclic derivative having inhibitory activity on type-i 11 data-hydroxysteroid dehydrogenase |
ES2372012T3 (es) * | 2008-03-05 | 2012-01-12 | Boehringer Ingelheim International Gmbh | Derivados de piridina tricíclicos, medicamentos que contienen a estos compuestos, su uso y procedimiento para su preparación. |
CA2790643A1 (en) | 2010-02-19 | 2011-08-25 | Boehringer Ingelheim International Gmbh | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
WO2013024130A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
CN107021940A (zh) * | 2017-05-03 | 2017-08-08 | 天津国际生物医药联合研究院 | 一种双哌嗪类化合物及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU529561B2 (en) * | 1979-02-13 | 1983-06-09 | Upjohn Company, The | Antiatherogenic 6-halofurochromones |
US4412071A (en) * | 1982-05-17 | 1983-10-25 | The Upjohn Company | Antiatherosclerotic compositions |
-
1989
- 1989-06-16 DE DE68919475T patent/DE68919475T2/de not_active Expired - Fee Related
- 1989-06-16 WO PCT/US1989/002572 patent/WO1990002129A1/en active IP Right Grant
- 1989-06-16 JP JP1507138A patent/JPH04500506A/ja active Pending
- 1989-06-16 EP EP89907579A patent/EP0429464B1/de not_active Expired - Lifetime
- 1989-06-16 KR KR1019900700773A patent/KR900701792A/ko not_active Application Discontinuation
- 1989-06-16 AT AT89907579T patent/ATE114311T1/de not_active IP Right Cessation
-
1991
- 1991-02-14 DK DK025691A patent/DK25691D0/da unknown
Also Published As
Publication number | Publication date |
---|---|
DK25691A (da) | 1991-02-14 |
JPH04500506A (ja) | 1992-01-30 |
AU3835889A (en) | 1990-03-23 |
DK25691D0 (da) | 1991-02-14 |
WO1990002129A1 (en) | 1990-03-08 |
AU631801B2 (en) | 1992-12-10 |
KR900701792A (ko) | 1990-12-04 |
EP0429464A1 (de) | 1991-06-05 |
DE68919475T2 (de) | 1995-05-11 |
DE68919475D1 (de) | 1995-01-05 |
EP0429464B1 (de) | 1994-11-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |