ATE111435T1 - Oxidative herstellung von a-nor-17-beta-carboxy- 3,5-seco-androstan-5-on-3-säure. - Google Patents
Oxidative herstellung von a-nor-17-beta-carboxy- 3,5-seco-androstan-5-on-3-säure.Info
- Publication number
- ATE111435T1 ATE111435T1 AT90907573T AT90907573T ATE111435T1 AT E111435 T1 ATE111435 T1 AT E111435T1 AT 90907573 T AT90907573 T AT 90907573T AT 90907573 T AT90907573 T AT 90907573T AT E111435 T1 ATE111435 T1 AT E111435T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- androstane
- seco
- carboxy
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 230000001590 oxidative effect Effects 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 abstract 3
- 150000003146 progesterones Chemical class 0.000 abstract 3
- 239000000186 progesterone Substances 0.000 abstract 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/18—Saturated compounds containing keto groups
- C07C62/24—Saturated compounds containing keto groups the keto group being part of a ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/18—Saturated compounds containing keto groups
- C07C62/26—Saturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35880089A | 1989-05-30 | 1989-05-30 | |
| US46241790A | 1990-01-09 | 1990-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE111435T1 true ATE111435T1 (de) | 1994-09-15 |
Family
ID=27000201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90907573T ATE111435T1 (de) | 1989-05-30 | 1990-05-15 | Oxidative herstellung von a-nor-17-beta-carboxy- 3,5-seco-androstan-5-on-3-säure. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0474666B1 (de) |
| JP (1) | JP2863786B2 (de) |
| AT (1) | ATE111435T1 (de) |
| AU (1) | AU5650590A (de) |
| CA (1) | CA2051397C (de) |
| DE (1) | DE69012558T2 (de) |
| DK (1) | DK0474666T3 (de) |
| ES (1) | ES2060164T3 (de) |
| HK (1) | HK64997A (de) |
| WO (1) | WO1990015045A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187925B1 (en) | 1997-12-23 | 2001-02-13 | Merck & Co., Inc. | Intermediates and process for the synthesis of azasteroids |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2727905A (en) * | 1952-08-21 | 1955-12-20 | Upjohn Co | Steroid alkali-metal enolates |
| FR1510055A (fr) * | 1966-12-06 | 1968-01-19 | Centre Nat Rech Scient | Procédé de préparation de seco-4-nor-céto-acides |
| US4220775A (en) * | 1979-03-15 | 1980-09-02 | Merck & Co., Inc. | Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors |
-
1990
- 1990-05-15 CA CA002051397A patent/CA2051397C/en not_active Expired - Fee Related
- 1990-05-15 WO PCT/US1990/002622 patent/WO1990015045A1/en not_active Ceased
- 1990-05-15 ES ES90907573T patent/ES2060164T3/es not_active Expired - Lifetime
- 1990-05-15 AU AU56505/90A patent/AU5650590A/en not_active Abandoned
- 1990-05-15 DK DK90907573.1T patent/DK0474666T3/da active
- 1990-05-15 DE DE69012558T patent/DE69012558T2/de not_active Expired - Fee Related
- 1990-05-15 JP JP2507607A patent/JP2863786B2/ja not_active Expired - Fee Related
- 1990-05-15 AT AT90907573T patent/ATE111435T1/de not_active IP Right Cessation
- 1990-05-15 EP EP90907573A patent/EP0474666B1/de not_active Expired - Lifetime
-
1997
- 1997-05-15 HK HK64997A patent/HK64997A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2060164T3 (es) | 1994-11-16 |
| CA2051397A1 (en) | 1991-07-10 |
| DE69012558T2 (de) | 1995-02-23 |
| DK0474666T3 (da) | 1995-02-06 |
| HK64997A (en) | 1997-05-23 |
| EP0474666A1 (de) | 1992-03-18 |
| DE69012558D1 (de) | 1994-10-20 |
| CA2051397C (en) | 1997-12-09 |
| WO1990015045A1 (en) | 1990-12-13 |
| JPH04505451A (ja) | 1992-09-24 |
| JP2863786B2 (ja) | 1999-03-03 |
| EP0474666B1 (de) | 1994-09-14 |
| AU5650590A (en) | 1991-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |