ATE110854T1 - Verfahren zur bestimmung von osteocalcin in humanem serum oder plasma. - Google Patents
Verfahren zur bestimmung von osteocalcin in humanem serum oder plasma.Info
- Publication number
- ATE110854T1 ATE110854T1 AT89118250T AT89118250T ATE110854T1 AT E110854 T1 ATE110854 T1 AT E110854T1 AT 89118250 T AT89118250 T AT 89118250T AT 89118250 T AT89118250 T AT 89118250T AT E110854 T1 ATE110854 T1 AT E110854T1
- Authority
- AT
- Austria
- Prior art keywords
- osteocalcin
- plasma
- tracer
- human serum
- oligopeptide
- Prior art date
Links
- 102000004067 Osteocalcin Human genes 0.000 title abstract 5
- 108090000573 Osteocalcin Proteins 0.000 title abstract 5
- 210000002966 serum Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000700 radioactive tracer Substances 0.000 abstract 5
- 108010038807 Oligopeptides Proteins 0.000 abstract 4
- 102000015636 Oligopeptides Human genes 0.000 abstract 4
- 229940124143 Endopeptidase inhibitor Drugs 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 229940097396 Aminopeptidase inhibitor Drugs 0.000 abstract 1
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 abstract 1
- 108010052590 amastatin Proteins 0.000 abstract 1
- QFAADIRHLBXJJS-ZAZJUGBXSA-N amastatin Chemical compound CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC(O)=O QFAADIRHLBXJJS-ZAZJUGBXSA-N 0.000 abstract 1
- 239000013060 biological fluid Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 108010052968 leupeptin Proteins 0.000 abstract 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3833936A DE3833936C1 (enExample) | 1988-10-05 | 1988-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110854T1 true ATE110854T1 (de) | 1994-09-15 |
Family
ID=6364464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89118250T ATE110854T1 (de) | 1988-10-05 | 1989-10-02 | Verfahren zur bestimmung von osteocalcin in humanem serum oder plasma. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5168041A (enExample) |
| EP (1) | EP0362773B1 (enExample) |
| JP (1) | JPH02147954A (enExample) |
| AT (1) | ATE110854T1 (enExample) |
| DE (2) | DE3833936C1 (enExample) |
| ES (1) | ES2057045T3 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05232109A (ja) * | 1990-10-04 | 1993-09-07 | Teijin Ltd | ヒト・オステオカルシンプロ蛋白の測定方法 |
| US5541116A (en) * | 1991-09-30 | 1996-07-30 | B.R.A.H.M.S. Diagnostica Gmbh | Method for the stabilization of endogenous, physiologically active peptides |
| US6632613B1 (en) * | 1993-06-02 | 2003-10-14 | University Of Utah Research Foundation | Compositions and kits for fluorescence polarization assay of large molecules |
| DE4340597C2 (de) * | 1993-11-29 | 1995-11-30 | Brahms Diagnostica Gmbh | Verfahren zur Verhinderung des Abbaus von Osteocalcin in humanem Serum oder Plasma f}r seine nachfolgende Bestimmung sowie Instrumente und Probengef{ße zur Durchf}hrung dieses Verfahrens |
| WO1995015981A1 (en) * | 1993-12-09 | 1995-06-15 | University Of Utah Research Foundation | Compositions and kits for fluorescence polarization assay of large molecules |
| US20040259167A1 (en) * | 1997-08-15 | 2004-12-23 | Jukka Hellman | Isolated osteocalcin fragments |
| DE19903336C2 (de) * | 1999-01-28 | 2000-12-14 | Brahms Diagnostica Gmbh | Gebrauchsfertige Kalibratoren für die Bestimmung von Procalcitonin |
| CH695985A5 (de) * | 2002-01-21 | 2006-11-15 | Straumann Holding Ag | Oberflächenmodifizierte Implantate. |
| DE10231574A1 (de) * | 2002-07-11 | 2004-01-29 | Sartorius Ag | Membran, Vorrichtung und Verfahren zum Entfernen von Proteasen aus Flüssigkeiten |
| EP2150816B1 (en) * | 2007-01-16 | 2014-11-26 | Mayo Foundation For Medical Education And Research | Assessing mammals for vascular diseases |
| JP4947725B2 (ja) * | 2008-03-28 | 2012-06-06 | ヤマサ醤油株式会社 | ジアセチルポリアミンの分解防止法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082612A (en) * | 1976-09-24 | 1978-04-04 | Michael Reese Research Foundation | Plasminogen activator complex |
| US4410506A (en) * | 1981-03-24 | 1983-10-18 | The Regents Of The University Of California | Immunoassay for vitamin K-dependent bone protein |
| US4438208A (en) * | 1982-05-27 | 1984-03-20 | The Regents Of The University Of California | Region-specific determinants for vitamin K dependent bone protein |
| US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
| US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
-
1988
- 1988-10-05 DE DE3833936A patent/DE3833936C1/de not_active Expired
-
1989
- 1989-10-02 AT AT89118250T patent/ATE110854T1/de not_active IP Right Cessation
- 1989-10-02 DE DE58908270T patent/DE58908270D1/de not_active Expired - Fee Related
- 1989-10-02 ES ES89118250T patent/ES2057045T3/es not_active Expired - Lifetime
- 1989-10-02 EP EP89118250A patent/EP0362773B1/de not_active Expired - Lifetime
- 1989-10-03 JP JP1258638A patent/JPH02147954A/ja active Pending
- 1989-10-03 US US07/416,728 patent/US5168041A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0362773A3 (de) | 1991-09-11 |
| EP0362773B1 (de) | 1994-08-31 |
| JPH02147954A (ja) | 1990-06-06 |
| EP0362773A2 (de) | 1990-04-11 |
| DE58908270D1 (de) | 1994-10-06 |
| DE3833936C1 (enExample) | 1989-09-21 |
| US5168041A (en) | 1992-12-01 |
| ES2057045T3 (es) | 1994-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69507019D1 (de) | Speicheltestverfahren und vorrichtung | |
| ATE110854T1 (de) | Verfahren zur bestimmung von osteocalcin in humanem serum oder plasma. | |
| DK0659275T3 (da) | Analytisk testapparat med indbygget negativ og positiv kontrol | |
| ATE91023T1 (de) | Verfahren und vorrichtungen zur durchfuehrung von untersuchungen. | |
| NO164866C (no) | Reagens og forsoeksinnretning til bestemmelse av tilstedevaerelsen av leukocytter, esterase og protease i en proeve. | |
| ATE17262T1 (de) | Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma. | |
| DE69736336D1 (de) | Verfahren zur messung von blutersatzstoffen | |
| ATE220112T1 (de) | Verfahren zum nachweis von störungen des protein c/protein s-systems | |
| ATE141650T1 (de) | Verfahren zur kinetischen bestimmung von faktor xiii | |
| ATE40718T1 (de) | Verfahren zur bestimmung von fibrinmonomer in plasma. | |
| DK425586A (da) | Fremgangsmaade til bestemmelse af proteaseinhibitorer | |
| ES8202639A1 (es) | Procedimiento para la deteccion y determinacion de monomero de fibrina en liquidos biologicos | |
| DE3373540D1 (en) | Salt bridge liquid for the potentiometric analysis of blood | |
| NO930705L (no) | Fremgangsmaate for bestemmelse av en vannbehandlingspolymer i en vandig proeve | |
| ATE136367T1 (de) | Verfahren zur bestimmung von hirudin und synthetischen trhombininhibitoren | |
| NO169022C (no) | Fremgangsmaate for simultanfotometrisk bestemmelse av prokallikrein og den partielle tromboplastintiden i plasma | |
| ATE135746T1 (de) | Enzymatisches verfahren zur bestimmung der analyt-konzentration | |
| ATE125623T1 (de) | Reduzierbare indikatoren, die pyrogallol enthalten und deren verwendung. | |
| AU2836299A (en) | Use of 14-3-3 proteins as sensitive biological markers for detecting pollution caused, inter alia, by polychlorinated biphenyl (pcb) and (xeno)oestrogen and method for quick determination of 14-3-3 proteins | |
| CA2466503A1 (en) | Total cysteine assay | |
| ATE85364T1 (de) | Verfahren zur bestimmung von plasminogen. | |
| ATE186600T1 (de) | Phosphattest | |
| ES8604691A1 (es) | Perfeccionamientos en los metodos para determinar la actividad de la catepsina b en presencia de otras enzimas proteoliticas | |
| ATE63166T1 (de) | Verfahren zur immunologischen bestimmung von aminen, monoklonale antikoerper und testsatz zur durchfuehrung des verfahrens. | |
| WO1995014788B1 (en) | Blood coagulation retardants and devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |