ATE109352T1 - Heilung von wunden. - Google Patents
Heilung von wunden.Info
- Publication number
- ATE109352T1 ATE109352T1 AT89906917T AT89906917T ATE109352T1 AT E109352 T1 ATE109352 T1 AT E109352T1 AT 89906917 T AT89906917 T AT 89906917T AT 89906917 T AT89906917 T AT 89906917T AT E109352 T1 ATE109352 T1 AT E109352T1
- Authority
- AT
- Austria
- Prior art keywords
- healing
- wounds
- mammal
- growth factor
- purified
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 abstract 2
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/196,975 US4983581A (en) | 1988-05-20 | 1988-05-20 | Wound healing composition of IGF-I and TGF-β |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE109352T1 true ATE109352T1 (de) | 1994-08-15 |
Family
ID=22727512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89906917T ATE109352T1 (de) | 1988-05-20 | 1989-05-22 | Heilung von wunden. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4983581A (de) |
| EP (1) | EP0419534B1 (de) |
| JP (1) | JPH0653674B2 (de) |
| AT (1) | ATE109352T1 (de) |
| DE (1) | DE68917300T2 (de) |
| WO (1) | WO1989011293A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256644A (en) * | 1988-05-20 | 1993-10-26 | Institute Of Molecular Biology, Inc. | Wound healing using IGF-II and TGF |
| US5145679A (en) * | 1989-10-05 | 1992-09-08 | Hinson Joan B | Topical emollient for prevention and treatment of circulatory induced lesions |
| ZA9010332B (en) * | 1989-12-22 | 1991-08-28 | Ciba Geigy | Method of reducing or preventing adverse effect of steroid therapy and compositions therefor |
| JP3377524B2 (ja) * | 1990-05-30 | 2003-02-17 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 創傷治癒 |
| US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
| US7229959B1 (en) | 1990-11-27 | 2007-06-12 | The American National Red Cross | Supplemented fibrin matrix delivery systems |
| US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| DE69132918T2 (de) * | 1990-11-27 | 2002-10-31 | American National Red Cross, Washington | Gewebeabdeckung und wachstumsfaktor enthaltende verbindungen zur förderung beschleunigter wundheilung |
| US6117425A (en) * | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5849686A (en) * | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US6211146B1 (en) * | 1991-03-11 | 2001-04-03 | Curis, Inc. | 60A protein-induced morphogenesis |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| CA2104678C (en) * | 1991-03-11 | 2002-05-14 | Charles M. Cohen | Protein-induced morphogenesis |
| US6399569B1 (en) | 1991-03-11 | 2002-06-04 | Curis, Inc. | Morphogen treatments for limiting proliferation of epithelial cells |
| SE9101840L (sv) * | 1991-06-14 | 1992-12-15 | Kabi Pharmacia | Ny medicinsk anvaendning |
| WO1993024627A1 (en) * | 1992-06-03 | 1993-12-09 | Case Western Reserve University | Bandage for continuous application of biologicals |
| US5444047A (en) * | 1994-06-16 | 1995-08-22 | Dipasquale; Gene | Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I |
| US5733884A (en) * | 1995-11-07 | 1998-03-31 | Nestec Ltd. | Enteral formulation designed for optimized wound healing |
| KR20000064752A (ko) | 1996-03-22 | 2000-11-06 | 더 제네랄 호스피탈 코포레이션 | 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법 |
| WO1998004681A2 (en) * | 1996-07-25 | 1998-02-05 | Genzyme Corporation | Chondrocyte media formulations and culture procedures |
| US20030220269A1 (en) * | 1997-03-24 | 2003-11-27 | Fujisawa Pharmaceutical Co., Ltd. | Bile secretagogues |
| US6221997B1 (en) | 1997-04-28 | 2001-04-24 | Kimberly Ann Woodhouse | Biodegradable polyurethanes |
| US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
| AU766826B2 (en) * | 1998-07-30 | 2003-10-23 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | Thymosin beta4 promotes wound repair |
| CA2350638C (en) | 1998-09-11 | 2009-11-24 | Gerhard Schmidmaier | Biologically active implants coated with a biodegradable polymer |
| KR100385293B1 (ko) * | 2000-05-13 | 2003-05-23 | 주식회사 리젠 바이오텍 | βｉｇ-ｈ3의 일부 도메인을 이용한 세포 부착 및 창상치유 방법 |
| US6648911B1 (en) | 2000-11-20 | 2003-11-18 | Avantec Vascular Corporation | Method and device for the treatment of vulnerable tissue site |
| GB2369572A (en) | 2000-11-29 | 2002-06-05 | Raft Trustees Ltd | Wound treatment composition comprising insulin |
| CA2498212C (en) | 2002-09-10 | 2012-07-17 | American National Red Cross | Multi-layered hemostatic dressing comprising thrombin and fibrinogen |
| WO2008019129A2 (en) * | 2006-08-04 | 2008-02-14 | Stb Lifesaving Technologies, Inc. | Solid dressing for treating wounded tissue |
| US20090075891A1 (en) * | 2007-08-06 | 2009-03-19 | Macphee Martin | Methods and dressings for sealing internal injuries |
| EP2379124B1 (de) | 2008-12-01 | 2016-01-27 | University College Cork, National University of Ireland, Cork | Igf1-freisetzender stent zur reparatur des myokards |
| US20120264689A1 (en) | 2009-10-07 | 2012-10-18 | Genogen, Inc. | Methods and compositions for skin regeneration |
| JP6871855B2 (ja) | 2014-10-14 | 2021-05-19 | サムエル リンチ， | 創傷を処置するための組成物 |
| US20210393746A1 (en) | 2018-09-26 | 2021-12-23 | National University Of Ireland, Galway | Treatment of myocardial infarction |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US468590A (en) * | 1892-02-09 | Upper-folding machine | ||
| DE2558537C2 (de) * | 1975-12-24 | 1984-07-19 | Hellmut Dr. 8000 München Mittenzwei | Verfahren zum Isolieren von Substanzen mit insulinähnlicher Wirksamkeit aus Blut oder Blutbestandteilen von Kälbern oder Schweinen |
| US4350687A (en) * | 1980-02-10 | 1982-09-21 | Research Corporation | Platelet derived cell growth factor |
| US4479896A (en) * | 1981-12-11 | 1984-10-30 | Antoniades Harry N | Method for extraction localization and direct recovery of platelet derived growth factor |
| DE3382562D1 (de) * | 1982-09-24 | 1992-06-25 | Us Health | Wiederherstellung von gewebe bei tieren. |
| JPS6028999A (ja) * | 1983-06-30 | 1985-02-14 | Maruho Kk | 細胞増殖促進作用を有するたんぱく質、その組成物と製造方法 |
| EP0154434B1 (de) * | 1984-02-17 | 1993-01-27 | Genentech, Inc. | Menschlicher Transformationswachstumsfaktor und Vorläufer oder Fragment hiervon, Zellen, DNA, Vektoren und Verfahren zu ihrer Herstellung, Zusammensetzungen und Produkte, die diese enthalten, sowie davon abgeleitete Antikörper und Diagnostizierverfahren |
| US4745179A (en) * | 1984-04-02 | 1988-05-17 | Fujisawa Pharmaceutical Co., Ltd. | 59 Valine insulin-like growth factor I and process for production thereof |
| US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
| US4702908A (en) * | 1985-11-01 | 1987-10-27 | Thorbecke G Jeanette | Composition containing platelet factor 4 and method for restoring suppressed immune responses |
| NZ235556A (en) * | 1986-11-05 | 1991-06-25 | Ethicon Inc | Breast milk substitute containing recombinant human egf |
| NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
-
1988
- 1988-05-20 US US07/196,975 patent/US4983581A/en not_active Expired - Lifetime
-
1989
- 1989-05-22 WO PCT/US1989/002229 patent/WO1989011293A1/en active IP Right Grant
- 1989-05-22 EP EP89906917A patent/EP0419534B1/de not_active Expired - Lifetime
- 1989-05-22 JP JP1506485A patent/JPH0653674B2/ja not_active Expired - Lifetime
- 1989-05-22 AT AT89906917T patent/ATE109352T1/de not_active IP Right Cessation
- 1989-05-22 DE DE68917300T patent/DE68917300T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03505870A (ja) | 1991-12-19 |
| WO1989011293A1 (en) | 1989-11-30 |
| EP0419534A1 (de) | 1991-04-03 |
| US4983581A (en) | 1991-01-08 |
| JPH0653674B2 (ja) | 1994-07-20 |
| DE68917300D1 (de) | 1994-09-08 |
| EP0419534A4 (en) | 1992-04-08 |
| DE68917300T2 (de) | 1995-02-23 |
| EP0419534B1 (de) | 1994-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |