ATA191078A - Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-20 a, ji-20 b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6 - Google Patents

Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-20 a, ji-20 b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6

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Publication number
ATA191078A
ATA191078A AT191078A AT191078A ATA191078A AT A191078 A ATA191078 A AT A191078A AT 191078 A AT191078 A AT 191078A AT 191078 A AT191078 A AT 191078A AT A191078 A ATA191078 A AT A191078A
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AT
Austria
Prior art keywords
epi
deoxy
derivatives
mutamicins
epiazido
Prior art date
Application number
AT191078A
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English (en)
Other versions
AT356816B (de
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ATA191078A publication Critical patent/ATA191078A/de
Application granted granted Critical
Publication of AT356816B publication Critical patent/AT356816B/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fodder In General (AREA)
AT191078A 1977-03-19 1978-03-17 Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-2- b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6 AT356816B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772712160 DE2712160A1 (de) 1977-03-19 1977-03-19 Pseudotrisaccharide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ATA191078A true ATA191078A (de) 1979-10-15
AT356816B AT356816B (de) 1980-05-27

Family

ID=6004119

Family Applications (1)

Application Number Title Priority Date Filing Date
AT191078A AT356816B (de) 1977-03-19 1978-03-17 Verfahren zur herstellung von neuen n-substi- tuierten derivaten der 4,6-di(aminoglycosyl)-1, 3-diaminocyclitole sisomicin, verdamicin, tobramycin, der kanamycine, der gentamicine a, b, b1, c1, c1a, c2, c2a, c2b, x2, der anti- biotika g-418, 66-40 b, 66-40 d, ji-20 a, ji-2- b und g-52 sowie deren 5-epi-, 5-epi-amino-5-desoxy- und 5-epiazido-5-desoxy- derivaten und der mutamicine 1,2,4,5 und 6

Country Status (11)

Country Link
US (1) US4199572A (de)
JP (1) JPS53116349A (de)
AT (1) AT356816B (de)
AU (1) AU3426378A (de)
BE (1) BE865015A (de)
DE (1) DE2712160A1 (de)
ES (1) ES467964A1 (de)
FR (1) FR2383963A1 (de)
GB (1) GB1584138A (de)
IT (1) IT7821336A0 (de)
NL (1) NL7802892A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282350A (en) * 1977-08-05 1981-08-04 Schering Corporation Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols
JPS5461151A (en) * 1977-10-25 1979-05-17 Shionogi & Co Ltd Novel aminoglycoside derivative
DE2832268A1 (de) * 1978-07-22 1980-01-31 Bayer Ag Pseudotrisaccharide
DE2936120A1 (de) * 1978-09-14 1980-03-27 Sandoz Ag Neue aminoglykoside, deren herstellung und deren verwendung als antimikrobielle mittel
DE2924659A1 (de) * 1979-06-19 1981-01-22 Bayer Ag Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel
US4493831A (en) * 1982-10-25 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Aminoglycoside derivatives
AR242396A1 (es) * 1985-10-15 1994-08-31 Schering Corp Procedimiento para preparar nelitimicina.
US5268168A (en) * 1990-02-19 1993-12-07 Sakai Engineering Co., Ltd. Antibacterial and deodorant processing agent and processing method using same
JP2717894B2 (ja) * 1990-10-11 1998-02-25 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
JP2811268B2 (ja) * 1992-10-16 1998-10-15 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料用の安定液、リンス液及びそれを用いた処理方法
AU2008326297B2 (en) * 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
US9238670B2 (en) * 2013-03-15 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Aminoglycoside antibiotics with reduced ototoxicity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920628A (en) * 1972-10-24 1975-11-18 Schering Corp 2{41 -Deoxyaminoglycosides and 2{41 -epi-amino-3{41 -desamino derivatives thereof, methods for their manufacture and novel intermediates useful therein
US4024332A (en) * 1973-06-05 1977-05-17 Pfizer Inc. Aminoglycoside antibiotics and intermediates therefor
US4002742A (en) * 1974-03-19 1977-01-11 Schering Corporation 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor
US4002608A (en) * 1975-11-04 1977-01-11 Schering Corporation 1-N-alkyl-aminoglycoside-XK-88 derivatives and methods for their manufacture
US4062947A (en) * 1975-11-04 1977-12-13 Schering Corporation Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor
US4085208A (en) * 1976-06-21 1978-04-18 Schering Corporation Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor

Also Published As

Publication number Publication date
US4199572A (en) 1980-04-22
ES467964A1 (es) 1978-11-16
NL7802892A (nl) 1978-09-21
AU3426378A (en) 1979-09-20
DE2712160A1 (de) 1978-09-28
FR2383963B1 (de) 1980-06-13
BE865015A (fr) 1978-09-18
GB1584138A (en) 1981-02-04
AT356816B (de) 1980-05-27
FR2383963A1 (fr) 1978-10-13
IT7821336A0 (it) 1978-03-17
JPS53116349A (en) 1978-10-11

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