AT77210B - Process for the preparation of a lipoid-like, nitrogen-containing compound from blood. - Google Patents
Process for the preparation of a lipoid-like, nitrogen-containing compound from blood.Info
- Publication number
- AT77210B AT77210B AT77210DA AT77210B AT 77210 B AT77210 B AT 77210B AT 77210D A AT77210D A AT 77210DA AT 77210 B AT77210 B AT 77210B
- Authority
- AT
- Austria
- Prior art keywords
- blood
- lipoid
- nitrogen
- preparation
- containing compound
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims description 5
- 210000004369 blood Anatomy 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 5
- -1 nitrogen-containing compound Chemical class 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 238000004821 distillation Methods 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 2
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 claims description 2
- 229940039790 sodium oxalate Drugs 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000000446 fuel Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<Desc/Clms Page number 1>
EMI1.1
In weiterer Ausbildung des durch das Stammpatent Nr. 73354 und dessem ersten Zusatzpatent Nr. 75374 geschützten Verfahrens wurde gefunden, dass man in dem Verfahren der Stammerfindung die dort zur Extraktion der beim Vermischen des eingeengten alkoholischen Auszuges mit Wasser erhaltenen Emulsion verwendetem chlorierten Kohlenwasserstoffe, wie Chloroform, ersetzen kann durch andere geeignete organische Lösungmittel, wie Äther, Benzol, Toluol, worauf man, wie in der Stammernndang beschrieben, die wirksame Substanz fällt und reinigt.
Das Verfahren wird durch folgendes Beispiel erläutert :
Man lässt 40 l Blut entweder in 4 kg einer einprozentigen Natriumoxalatlösung oder in 10 kg einer 26%igen MagnesiumsulfatJösung unter Umrühren einlaufen und kocht diese Mischung am Rückflusskühler mit 120 l hochprozentigem Alkohol während fünf Stunden. Hierauf wird der Spritextrakt bei zirka 70"0 nitriert. Der in Sprit unlösliche Anteil wird leicht ausgepresst und nochmals mit 40 l hochprozentigem Alkohol fünf Stunden in der angegebenen Weise gekocht. Es wird wiederum bei 700 C filtriert und der Rückstand scharf ausgepresst.
Die Spritlösung wird sofort im hohen Vakuum und bei niedriger Temperatur eingedampft ; gegen das Ende der Destillation werden 10 1 destilliertes Wasser eingesaugt und die Destillation so geleitet, dass zum Schluss noch 16 bis 20 l Emulsion verbleiben. Diese Emulsion wird dreimal nacheinander mit je 10 kg Äther je zirka zehn Minuten ausgerührt. Die erhaltene Ätherlösung wird auf zirka 4 l eingedampft und nnter gutem Schütteln bzw. Rühren mit zirka 6 l Aceton versetzt. Die hiebei entstandene Fällung wird abfiltriert, mit Äther ausgerührt und die Ätherlösung im Vakuum zur Trockne eingedampft. Das erhaltene Produkt ist identisch mit dem in der Stammerfindung beschriebenen.
An Stelle des in vorstehendem Beispiel angewendeten Äthers können zur Extraktion der Emulsion mit ähnlichem Erfolg auch andere organische Lösungsmittel, wie z. B. Benzol oder Toluol, verwendet werden.
**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
EMI1.1
In a further development of the process protected by the parent patent No. 73354 and its first additional patent No. 75374, it was found that the chlorinated hydrocarbons used there for the extraction of the emulsion obtained when the concentrated alcoholic extract was mixed with water, such as chloroform, in the process of the parent invention , can be replaced by other suitable organic solvents such as ether, benzene, toluene, whereupon, as described in the Stammernndang, the active substance is precipitated and purified.
The procedure is illustrated by the following example:
40 liters of blood are poured into either 4 kg of a 1% sodium oxalate solution or 10 kg of a 26% magnesium sulfate solution while stirring and this mixture is boiled on a reflux condenser with 120 liters of high percentage alcohol for five hours. The fuel extract is then nitrated at about 70 "0. The fraction that is insoluble in fuel is squeezed out slightly and boiled again with 40 liters of high-percentage alcohol for five hours in the manner indicated. It is again filtered at 700 ° C. and the residue is squeezed sharply.
The fuel solution is immediately evaporated in a high vacuum and at low temperature; Towards the end of the distillation, 10 l of distilled water are sucked in and the distillation is directed in such a way that 16 to 20 l of emulsion remain at the end. This emulsion is stirred three times in succession with 10 kg of ether each time for about ten minutes. The ether solution obtained is evaporated to approx. 4 l and mixed with approx. 6 l of acetone while shaking or stirring well. The resulting precipitate is filtered off, stirred up with ether and the ether solution is evaporated to dryness in vacuo. The product obtained is identical to that described in the parent invention.
Instead of the ether used in the above example, other organic solvents, such as. B. benzene or toluene can be used.
** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT73354T | 1915-07-14 | ||
| AT77210T | 1917-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT77210B true AT77210B (en) | 1919-07-25 |
Family
ID=25603736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT77210D AT77210B (en) | 1915-07-14 | 1917-04-26 | Process for the preparation of a lipoid-like, nitrogen-containing compound from blood. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT77210B (en) |
-
1917
- 1917-04-26 AT AT77210D patent/AT77210B/en active
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