AT76844B - Process for the production of an aluminum preparation that gradually dissolves in the intestine and has a gently astringent effect. - Google Patents
Process for the production of an aluminum preparation that gradually dissolves in the intestine and has a gently astringent effect.Info
- Publication number
- AT76844B AT76844B AT76844DA AT76844B AT 76844 B AT76844 B AT 76844B AT 76844D A AT76844D A AT 76844DA AT 76844 B AT76844 B AT 76844B
- Authority
- AT
- Austria
- Prior art keywords
- intestine
- gently
- production
- astringent effect
- gradually dissolves
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 title claims description 5
- 229910052782 aluminium Inorganic materials 0.000 title claims description 5
- 230000000694 effects Effects 0.000 title claims description 5
- 210000000936 intestine Anatomy 0.000 title claims description 3
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 150000001447 alkali salts Chemical class 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000009965 odorless effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- GQCYCMFGFVGYJT-UHFFFAOYSA-N [AlH3].[S] Chemical compound [AlH3].[S] GQCYCMFGFVGYJT-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
<Desc/Clms Page number 1>
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haben nämlich die Eigenschaft, in Wasser sofort zu dissozieren und führen dadurch zu unliebsamen Säurewirkungen ; unlösliche Salze wie die Silikate (Bolus alba) wirken absolut nicht adstringierend, sondern nur rein mechan'sch-phys kalisch als feines Pulver w : e Blutkohle und andere feine, unlösliche Pulver. Die schwierige Anwendbarkeit der Aluminiumpräparate für unseren Gebrauch ist um so mehr zu bedauern, als s e sch gegenüber dem einzigen diesbeziiglichen Ersat1. mittel, dem Bismutum subnitricum, durch völlige Ungiftigkeit vorbeilhaft unterscheiden.
Es wurde deshalb versucht, ein kolloidales Aluminiumpräparat herzustellen, das sei r langsam im Darm bei alkalischer Reaktion in Lösung geht und so äusserst milde aber auch sehr anhaltend bis in die tieferen Darmabschnitte adstringierend wirkt.
Ein lösliches Alumin umaalz wird in Wasser zu einer klaren Lösung gebracht und darauf
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säure, tiefe oder hohe Temperaturen usw. Der entstandene gallertigbreiige Niederschlag wird abgesaugt, mit Wasser bis zur Salzfreiheit ausgewaschen, getrocknet und pulveris ert. Daä so erhaltene Präparat ist in verdünnter Salzsäure nur in Spuren löslich, m verdünnter Lauge geht es allmählich in eine kolloidale Lösung über.
Versuche an der medizinischen Klinik in Zürich haben eine ausgezeichnete adstringierende Wirkung des geruch- und geschmacklosen Präparates bei den verschiedensten Arten von Durch-
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Beispiel :
200 Aluminium sulfur. cryst. purs. werden in 500 cm3 heissen Wassers gelöst, die schwach getrübte Lösung wird klar filtriert. Es werden derselben 30 g reinste Gelatine, klar gelöst, in
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lauge (zirkii 145 cm3 einer 35% igen Lauge) langsam zugesetzt, so dass alle Schwefelsäure neutralisiert und die Reaktion genau neutral geworden ist. Unter kräftigem Umrühren werden
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wird der Niederschlag getrocknet und pulver : sert.
Das Präparat ist geruch-und geschmacklos, in verdünnter Salzsäure nur in Spuren löslich
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**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.
<Desc / Clms Page number 1>
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namely have the property of dissociating immediately in water and thus lead to undesirable acidic effects; Insoluble salts such as the silicates (Bolus alba) have absolutely no astringent effect, but only purely mechanically and physically as a fine powder such as blood carbon and other fine, insoluble powders. The difficulty in applying the aluminum preparations for our use is all the more regrettable as it is compared to the only relevant substitute. medium, the Bismutum subnitricum, by being completely non-toxic.
An attempt was therefore made to produce a colloidal aluminum preparation that slowly dissolves in the intestine with an alkaline reaction and thus has an extremely mild but also very persistent astringent effect into the deeper intestinal sections.
A soluble aluminum umaalz is brought to a clear solution in water and on top
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acid, low or high temperatures, etc. The resulting gelatinous precipitate is suctioned off, washed out with water until salt-free, dried and pulverized. The preparation obtained in this way is only soluble in trace amounts in dilute hydrochloric acid; in dilute lye it gradually turns into a colloidal solution above.
Tests at the medical clinic in Zurich have shown an excellent astringent effect of the odorless and tasteless preparation in the most diverse types of penetration.
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Example:
200 aluminum sulfur. cryst. purs. are dissolved in 500 cm3 of hot water, the slightly cloudy solution is filtered clear. There are the same 30 g of the purest gelatin, clearly dissolved, in
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lye (about 145 cm3 of a 35% lye) slowly added so that all sulfuric acid is neutralized and the reaction has become exactly neutral. While stirring vigorously
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the precipitate is dried and powder: sert.
The preparation is odorless and tasteless and only soluble in traces in dilute hydrochloric acid
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** WARNING ** End of DESC field may overlap beginning of CLMS **.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH76844X | 1916-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT76844B true AT76844B (en) | 1919-06-25 |
Family
ID=4328974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT76844D AT76844B (en) | 1916-06-05 | 1916-06-19 | Process for the production of an aluminum preparation that gradually dissolves in the intestine and has a gently astringent effect. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT76844B (en) |
-
1916
- 1916-06-19 AT AT76844D patent/AT76844B/en active
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