AT50329B - Process for the preparation of effective tuberculosis immune sera. - Google Patents

Process for the preparation of effective tuberculosis immune sera.

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Publication number
AT50329B
AT50329B AT50329DA AT50329B AT 50329 B AT50329 B AT 50329B AT 50329D A AT50329D A AT 50329DA AT 50329 B AT50329 B AT 50329B
Authority
AT
Austria
Prior art keywords
tuberculin
preparation
immune sera
tuberculosis
hypersensitivity
Prior art date
Application number
Other languages
German (de)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AT50329B publication Critical patent/AT50329B/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

  

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 gelöst werden knnte, die Injektion von Tuberkelbazillen des typus bovinus allein. Wiederum trat Tuberkulinüberempfindlichkeit ein, die in der geschilderten Weise durch Injektion von   Tubcrkulin   allmählich zum Schwinden gebracht und zur Steigerung des Gehaltes an Immunstoffen benutzt werden   konu. 3. Jedesmal   nach Schwinden der Tuberkulinüberempfindlichkeit wurde im Laufe der Behandlung das Blutserum des Rindes in vitro auf seinen Gehalt an Immunstoffen geprüft. Dabei   ergab sich deren allmähliche Steigerung.   So war schliesslich der Agglutinationatiter auf 3000 gestiegen.

   Der Gehalt an komplementbindender Substanz wurde dadurch 
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   Komplements im hämolytischen System ergab. Der opsonische Index   des   Immunserums   konnte im Laufe der Behandlung bis auf 2-0 gesteigert werden.



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 The injection of bovine tubercle bacilli alone could be solved. Again hypersensitivity to tuberculin occurred, which was gradually reduced in the manner described by the injection of tubeculin and used to increase the content of immune substances. 3. Each time after the tuberculin hypersensitivity had subsided, the cattle blood serum was tested in vitro for its content of immune substances during the treatment. This resulted in their gradual increase. So finally the agglutination titer had risen to 3000.

   The content of complement-binding substance was thereby
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   Revealed complements in the hemolytic system. The opsonic index of the immune serum could be increased to 2-0 in the course of the treatment.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung wirksamer Tuberkuloseimmunsera, dadurch gekennzeichnet, dass man normale., an sich nicht tuberkulinüberempfndliche Tiere durch Einspritzungen von lebenden, für die betreffende Tierart apathogenen Tuberkelbazillen tuberkelinüberempnndlich macht, die entstandene Tuberkulinüberempfindli8chkeit durch Einspritzen von Tuberkulin oder anderen Tuberkelbazillenpräparaten in steigenden Mengen wieder zum Verschwinden bringt, dann durch Einspritzungen gesteigerter Mengen lebende, für die betreffende Tierart pathogener Tuberkelbazillen die geschwundene Tuberkulinüberempfindlichkeit immer erneut hervorruft und gegebcnenfaDs wiederum durch Behandlung mit Tuberkulin oder anderen Tuberkelbazillenpriiparaten hcseitigt0 PATENT CLAIM: A method for the preparation of effective tuberculosis immune sera, characterized in that normal animals, which are not per se not hypersensitive to tuberculin, are made hypersensitive to tuberculosis by injections of living tuberculosis bacilli which are apathogenic for the animal species in question, and the resulting hypersensitivity to tuberculin is made to disappear again by injecting increasing amounts of tuberculin or other tuberculous drugs , then by injecting increased amounts of live tubercle bacilli which are pathogenic for the animal species concerned, the tuberculin hypersensitivity that has disappeared repeatedly provokes anew and may be eliminated again by treatment with tuberculin or other tubercle bacilli specimens
AT50329D 1909-07-22 1910-07-04 Process for the preparation of effective tuberculosis immune sera. AT50329B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE50329X 1909-07-22

Publications (1)

Publication Number Publication Date
AT50329B true AT50329B (en) 1911-10-25

Family

ID=5626615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT50329D AT50329B (en) 1909-07-22 1910-07-04 Process for the preparation of effective tuberculosis immune sera.

Country Status (1)

Country Link
AT (1) AT50329B (en)

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