AT43101B - Process for the preparation of a salt of dibromomehenic acid. - Google Patents
Process for the preparation of a salt of dibromomehenic acid.Info
- Publication number
- AT43101B AT43101B AT43101DA AT43101B AT 43101 B AT43101 B AT 43101B AT 43101D A AT43101D A AT 43101DA AT 43101 B AT43101 B AT 43101B
- Authority
- AT
- Austria
- Prior art keywords
- salt
- acid
- dibromomehenic
- preparation
- alcohol
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 8
- 239000002253 acid Substances 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
<Desc/Clms Page number 1>
Verfahren zur Darstellung eines Salzes der Dibrombehensäure.
In den Annalen 135, Seite 228, sind das Bariumsalz und das Bleisalz der durch Einwirkung von Brom auf Erucasäure erhältlichen Dibrombehensäure beschrieben worden. Ganz abgesehen davon, dass diese Salze schon wegen ihrer Giftigkeit für therapeutische Zwecke unbrauchbar sind, sind dieselben auch, wie l. e. ausdrücklich erwähnt wird, nicht haltbar, zeretzen sich viel-
EMI1.1
Halle angestellten Versuchen stellt das Kalziumsalz der Dibrombehensäure einen hervorragenden Ersatz für die bisher in der Thernpie gebrauchten Bromalkalien dar, indem es bei gleicher Wirkung
EMI1.2
mit überschüssigem Ammoniak versetzten Lösung des Kalziumsalzes zufügt.
Beispiel 1.
30 Teile kristallisiertes Chlorkalzium werden in 150 Teilen Alkohol warm gelost und in
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Dibrombehensäure, die aus Erucasäure durch Anlagerung von Brom gewonnen wird, in 200 Teilen Alkohol einfliessen. Das Kalksalz scheidet sich als farbloser dicker Niederschlag ab, der scharf abgesaugt und mit Alkohol gewaschen wird. Dann verreibt man ihn mit kaltem Wasser, saugt wieder ab und wäscht mit Wasser, bis zum Verschwinden der Chlroreaktion. Zum Schluss wird das Salz nochmals mit Alkohol gewaschen und im Vakuum getrocknet. Es bildet ein farbloses, geschmackloses, haltbares, in Wasser und Alkohol fast. unlösliches Pulver.
Beispiel 2.
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<Desc/Clms Page number 2>
Flüssigkeit durchgerührt und abgekühlt, wobei das Salz wieder erstarrt. Nach Abgiessen des Alkohols bildet es eine pulverige, leicht zerreibliche Masse, die abfiltriert, mit Alkohol gewaschen und im Vakuum getrocknet wird.
<Desc / Clms Page number 1>
Process for the preparation of a salt of dibromomehenic acid.
In Annalen 135, page 228, the barium salt and the lead salt of the dibromomehenic acid obtainable by the action of bromine on erucic acid have been described. Quite apart from the fact that these salts are unsuitable for therapeutic purposes because of their toxicity, they are also, like l. e. is expressly mentioned, not durable, often decompose
EMI1.1
Halle's experiments, the calcium salt of dibromomehenic acid represents an excellent substitute for the bromine-alkalis hitherto used in therapy, since it has the same effect
EMI1.2
with excess ammonia added solution of the calcium salt.
Example 1.
30 parts of crystallized calcium chloride are dissolved in 150 parts of warm alcohol and in
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Dibromomehenic acid, which is obtained from erucic acid by the addition of bromine, is poured into 200 parts of alcohol. The lime salt separates out as a colorless, thick precipitate, which is sharply suctioned off and washed with alcohol. Then rub it with cold water, suction off again and wash with water until the chlorine reaction disappears. Finally, the salt is washed again with alcohol and dried in vacuo. It makes a colorless, tasteless, tough, almost in water and alcohol. insoluble powder.
Example 2.
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<Desc / Clms Page number 2>
The liquid is stirred through and cooled, the salt solidifying again. After the alcohol has been poured off, it forms a powdery, easily friable mass which is filtered off, washed with alcohol and dried in vacuo.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT43101D AT43101B (en) | 1908-07-21 | 1909-01-25 | Process for the preparation of a salt of dibromomehenic acid. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT43101X | 1908-07-21 | ||
| AT43101D AT43101B (en) | 1908-07-21 | 1909-01-25 | Process for the preparation of a salt of dibromomehenic acid. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT43101B true AT43101B (en) | 1910-07-25 |
Family
ID=25601039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT43101D AT43101B (en) | 1908-07-21 | 1909-01-25 | Process for the preparation of a salt of dibromomehenic acid. |
Country Status (1)
| Country | Link |
|---|---|
| AT (1) | AT43101B (en) |
-
1909
- 1909-01-25 AT AT43101D patent/AT43101B/en active
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