AT364881B - Verfahren zur herstellung neuer aminoglykosid-antibiotika - Google Patents

Verfahren zur herstellung neuer aminoglykosid-antibiotika

Info

Publication number
AT364881B
AT364881B AT0012879A AT12879A AT364881B AT 364881 B AT364881 B AT 364881B AT 0012879 A AT0012879 A AT 0012879A AT 12879 A AT12879 A AT 12879A AT 364881 B AT364881 B AT 364881B
Authority
AT
Austria
Prior art keywords
aminoglycoside antibiotics
producing new
new aminoglycoside
antibiotics
producing
Prior art date
Application number
AT0012879A
Other languages
English (en)
Other versions
ATA12879A (de
Inventor
Yoshihiko Oka
Hitoshi Ishida
Moto Morioka
Yoso Numasaki
Tsutomu Yamafuji
Takashi Osono
Hamao Umezawa
Original Assignee
Yamanouchi Pharma Co Ltd
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd, Microbial Chem Res Found filed Critical Yamanouchi Pharma Co Ltd
Publication of ATA12879A publication Critical patent/ATA12879A/de
Application granted granted Critical
Publication of AT364881B publication Critical patent/AT364881B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/867—Micromonospora

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT0012879A 1978-01-13 1979-01-08 Verfahren zur herstellung neuer aminoglykosid-antibiotika AT364881B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53003188A JPS6030320B2 (ja) 1978-01-13 1978-01-13 新規抗生物質およびその製造法

Publications (2)

Publication Number Publication Date
ATA12879A ATA12879A (de) 1981-04-15
AT364881B true AT364881B (de) 1981-11-25

Family

ID=11550416

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0012879A AT364881B (de) 1978-01-13 1979-01-08 Verfahren zur herstellung neuer aminoglykosid-antibiotika

Country Status (10)

Country Link
US (2) US4209511A (de)
JP (1) JPS6030320B2 (de)
AT (1) AT364881B (de)
CA (1) CA1115224A (de)
DE (1) DE2900315C2 (de)
ES (1) ES476814A1 (de)
FR (1) FR2414513B1 (de)
GB (1) GB2012267B (de)
IT (1) IT1118286B (de)
NL (1) NL186699C (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412068A (en) * 1981-06-08 1983-10-25 Sterling Drug Inc. Novel compounds of the gentamicin class
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
WO2009152202A2 (en) * 2008-06-11 2009-12-17 Utah State University New aminoglycosides: synthesis and use as antifungals
WO2012082650A2 (en) * 2010-12-14 2012-06-21 Utah State University Aminoglycosides:synthesis and use as antifungals
US9669044B2 (en) 2010-12-14 2017-06-06 Utah State University Aminoglycoside and azole compositions and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045298A (en) * 1972-05-27 1977-08-30 Abbott Laboratories Antibiotic XK-62-2 and process for production thereof
JPS5220991B2 (de) * 1972-08-23 1977-06-07
US4024332A (en) * 1973-06-05 1977-05-17 Pfizer Inc. Aminoglycoside antibiotics and intermediates therefor
US4132846A (en) * 1974-03-07 1979-01-02 Abbott Laboratories 1-N-(α-Hydroxy-β-aminopropionyl) XK-62-2 and method of production thereof
US3982996A (en) * 1975-09-22 1976-09-28 Sterling Drug Inc. Process for preparing aminocyclitol antibiotics
NZ185515A (en) * 1976-10-28 1980-08-26 Abbott Lab Fortimicin d and ke from culturing micromonospora olivoasterospora

Also Published As

Publication number Publication date
CA1115224A (en) 1981-12-29
DE2900315A1 (de) 1979-07-19
ES476814A1 (es) 1979-10-16
ATA12879A (de) 1981-04-15
GB2012267A (en) 1979-07-25
NL186699C (nl) 1991-02-01
JPS5498741A (en) 1979-08-03
US4209511A (en) 1980-06-24
NL7900265A (nl) 1979-07-17
FR2414513A1 (de) 1979-08-10
IT1118286B (it) 1986-02-24
DE2900315C2 (de) 1986-06-26
NL186699B (nl) 1990-09-03
FR2414513B1 (de) 1980-09-19
JPS6030320B2 (ja) 1985-07-16
IT7967067A0 (it) 1979-01-12
GB2012267B (en) 1982-06-09
US4279997A (en) 1981-07-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee