AT335437B - PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT - Google Patents

PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Info

Publication number
AT335437B
AT335437B AT449075A AT449075A AT335437B AT 335437 B AT335437 B AT 335437B AT 449075 A AT449075 A AT 449075A AT 449075 A AT449075 A AT 449075A AT 335437 B AT335437 B AT 335437B
Authority
AT
Austria
Prior art keywords
sep
biphenylyl
amides
esters
salt
Prior art date
Application number
AT449075A
Other languages
German (de)
Other versions
ATA449075A (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732341507 external-priority patent/DE2341507A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to AT449075A priority Critical patent/AT335437B/en
Publication of ATA449075A publication Critical patent/ATA449075A/en
Application granted granted Critical
Publication of AT335437B publication Critical patent/AT335437B/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

   <Desc/Clms Page number 1> 
 
 EMI1.1 
 
 EMI1.2 
 
 EMI1.3 
 
 EMI1.4 
 
 EMI1.5 
 
 EMI1.6 
 

 <Desc/Clms Page number 2> 

 
 EMI2.1 
 
 EMI2.2 
 
 EMI2.3 
 

 <Desc/Clms Page number 3> 

 
 EMI3.1 
 

 <Desc/Clms Page number 4> 

 
 EMI4.1 
 
<tb> 
<tb> 



  (4-Biphenylyl) <SEP> -buttersäuren,Substanz <SEP> Kaolinödem <SEP> Carrageenin- <SEP> Mittelwert <SEP> akute <SEP> Toxizität <SEP> Ratte <SEP> Therapeut. <SEP> Index
<tb> ED35 <SEP> per <SEP> os <SEP> ödem <SEP> ED35
<tb> mg/kg <SEP> ED35 <SEP> per <SEP> os <SEP> mg/kg <SEP> mg/kg <SEP> Vertr.

   <SEP> Grenzen <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> toxischer <SEP> und
<tb> mg/kg <SEP> 95%iger <SEP> Wahrschein- <SEP> antiexsudativer <SEP> Wirkung
<tb> lichkeit <SEP> LD50/ED35
<tb> Phenylbutazon <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13,6
<tb> A <SEP> 11 <SEP> 9,3 <SEP> 10,1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98,5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 
<tb> 
 

 <Desc/Clms Page number 5> 

 
 EMI5.1 
 
<tb> 
<tb> Substanz <SEP> Mittelwert <SEP> Ulcerogene <SEP> Wirkung <SEP> Therapeutischer <SEP> Index
<tb> ED35 <SEP> ED50 <SEP> (U)

   <SEP> Vertrauensbereich <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> ulcerogener <SEP> und
<tb> mg/kg <SEP> 95%iger <SEP> Wahrscheinlichkeit <SEP> antiexsudativer <SEP> Wirkung
<tb> mg/kg <SEP> ED <SEP> (U)/ED
<tb> 50 <SEP> 35 <SEP> 
<tb> Phenylbutazon <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP> 
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, <SEP> 77 <SEP> 
<tb> B <SEP> 9,95 <SEP> 27,0 <SEP> 15,88 <SEP> - <SEP> 45,90 <SEP> 2,71
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP> 
<tb> 
 

 <Desc/Clms Page number 6> 

 
 EMI6.1 
 
 EMI6.2 
 

 <Desc/Clms Page number 7> 

 
 EMI7.1 
 
 EMI7.2 
 

 <Desc/Clms Page number 8> 

 
 EMI8.1 
 
 EMI8.2 
 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 
 EMI1.1
 
 EMI1.2
 
 EMI1.3
 
 EMI1.4
 
 EMI1.5
 
 EMI1.6
 

 <Desc / Clms Page number 2>

 
 EMI2.1
 
 EMI2.2
 
 EMI2.3
 

 <Desc / Clms Page number 3>

 
 EMI3.1
 

 <Desc / Clms Page number 4>

 
 EMI4.1
 
<tb>
<tb>



  (4-biphenylyl) <SEP> -butyric acids, substance <SEP> kaolin edema <SEP> carrageenin <SEP> mean value <SEP> acute <SEP> toxicity <SEP> rat <SEP> therapist. <SEP> index
<tb> ED35 <SEP> per <SEP> os <SEP> edema <SEP> ED35
<tb> mg / kg <SEP> ED35 <SEP> per <SEP> os <SEP> mg / kg <SEP> mg / kg <SEP> contract.

   <SEP> limits <SEP> at <SEP> ratio <SEP> between <SEP> toxic <SEP> and
<tb> mg / kg <SEP> 95% iger <SEP> probable <SEP> anti-exudative <SEP> effect
<tb> ability <SEP> LD50 / ED35
<tb> Phenylbutazone <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13.6
<tb> A <SEP> 11 <SEP> 9.3 <SEP> 10.1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98.5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP>
<tb>
 

 <Desc / Clms Page number 5>

 
 EMI5.1
 
<tb>
<tb> substance <SEP> mean value <SEP> ulcerogenic <SEP> effect <SEP> therapeutic <SEP> index
<tb> ED35 <SEP> ED50 <SEP> (U)

   <SEP> Confidence range <SEP> at <SEP> ratio <SEP> between <SEP> ulcerogenic <SEP> and
<tb> mg / kg <SEP> 95% <SEP> probability <SEP> antiexudative <SEP> effect
<tb> mg / kg <SEP> ED <SEP> (U) / ED
<tb> 50 <SEP> 35 <SEP>
<tb> Phenylbutazone <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP>
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, < SEP> 77 <SEP>
<tb> B <SEP> 9.95 <SEP> 27.0 <SEP> 15.88 <SEP> - <SEP> 45.90 <SEP> 2.71
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP >
<tb>
 

 <Desc / Clms Page number 6>

 
 EMI6.1
 
 EMI6.2
 

 <Desc / Clms Page number 7>

 
 EMI7.1
 
 EMI7.2
 

 <Desc / Clms Page number 8>

 
 EMI8.1
 
 EMI8.2
 

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

EMI8.3 EMI8.4 EMI8.5 EMI8.6 <Desc/Clms Page number 9> Beispielemit Ammoniak zu einem Amid der Formel (I) umgesetzt wird. EMI9.1 nach Anspruch 1, dadurchder Formel (II) durch Silber-(I)-oxyd, Natriumthiosulfat, Kaliumhydroxyd in Methanol und/oder Wasser, katalysiert wird. EMI8.3 EMI8.4 EMI8.5 EMI8.6 <Desc / Clms Page number 9> Examples with ammonia is converted to an amide of formula (I). EMI9.1 according to claim 1, characterized in that the formula (II) is catalyzed by silver (I) oxide, sodium thiosulphate, potassium hydroxide in methanol and / or water.
AT449075A 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT AT335437B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT449075A AT335437B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732341507 DE2341507A1 (en) 1973-08-16 1973-08-16 NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING
AT577674A AT331235B (en) 1973-08-16 1974-07-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT
AT449075A AT335437B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Publications (2)

Publication Number Publication Date
ATA449075A ATA449075A (en) 1976-07-15
AT335437B true AT335437B (en) 1977-03-10

Family

ID=27149987

Family Applications (1)

Application Number Title Priority Date Filing Date
AT449075A AT335437B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Country Status (1)

Country Link
AT (1) AT335437B (en)

Also Published As

Publication number Publication date
ATA449075A (en) 1976-07-15

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