AT335435B - PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT - Google Patents

PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Info

Publication number
AT335435B
AT335435B AT448775A AT448775A AT335435B AT 335435 B AT335435 B AT 335435B AT 448775 A AT448775 A AT 448775A AT 448775 A AT448775 A AT 448775A AT 335435 B AT335435 B AT 335435B
Authority
AT
Austria
Prior art keywords
sep
biphenylyl
amides
esters
new
Prior art date
Application number
AT448775A
Other languages
German (de)
Other versions
ATA448775A (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732341507 external-priority patent/DE2341507A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to AT448775A priority Critical patent/AT335435B/en
Publication of ATA448775A publication Critical patent/ATA448775A/en
Application granted granted Critical
Publication of AT335435B publication Critical patent/AT335435B/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

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<tb> 
<tb> betrtfff, <SEP> einVerfahrenzurHerstellungneuer3- <SEP> (4-Biphenylyl)-buttersa. <SEP> uren, <SEP> ihrerSubstanz <SEP> Kaolinödem <SEP> Carrageenin- <SEP> Mittel- <SEP> akute <SEP> Toxizität <SEP> Ratte <SEP> Therapeut. <SEP> Index
<tb> ED35 <SEP> per <SEP> os <SEP> ödem <SEP> wert
<tb> mg/kg <SEP> ED35 <SEP> per <SEP> os <SEP> ED35 <SEP> mg/kg <SEP> Vertr.

   <SEP> Grenzen <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> toximg/kg <SEP> mg/kg <SEP> 95%iger <SEP> Wahr- <SEP> scher <SEP> und <SEP> anti <SEP> exsudativer <SEP> 
<tb> scheinlichkeit <SEP> Wirkung
<tb> LD50/ED35
<tb> Phenylbutazon <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13, <SEP> 6
<tb> A <SEP> 11 <SEP> 9, <SEP> 3 <SEP> 10, <SEP> 1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98, <SEP> 5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 
<tb> 
 

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<tb> 
<tb> Substanz <SEP> Mittelwert <SEP> Ulcerogene <SEP> Wirkung <SEP> Therapeutischer <SEP> Index
<tb> ED35
<tb> ED50 <SEP> (U)

   <SEP> Vertrauensbereich <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> ulcerogener <SEP> und
<tb> mg/kg <SEP> 95%iger <SEP> Wahrscheinlichkeit <SEP> antiexsudativer <SEP> Wirkung
<tb> mg/kg <SEP> ED50 <SEP> (U)/ED35 <SEP> 
<tb> Phenylbutazon <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15,38 <SEP> - <SEP> 50,96 <SEP> 2, <SEP> 77
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15,88- <SEP> 45,90 <SEP> 2, <SEP> 71
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP> 
<tb> 
 

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<tb>
<tb> betrtfff, <SEP> a process for the production of new 3- <SEP> (4-biphenylyl) -buttersa. <SEP> uren, <SEP> their substance <SEP> kaolin edema <SEP> carrageenin- <SEP> medium- <SEP> acute <SEP> toxicity <SEP> rat <SEP> therapist. <SEP> index
<tb> ED35 <SEP> per <SEP> os <SEP> edema <SEP> value
<tb> mg / kg <SEP> ED35 <SEP> per <SEP> os <SEP> ED35 <SEP> mg / kg <SEP> contract.

   <SEP> Limits <SEP> at <SEP> ratio <SEP> between <SEP> toximg / kg <SEP> mg / kg <SEP> 95% <SEP> probable <SEP> shear <SEP> and <SEP> anti <SEP> exudative <SEP>
<tb> probability <SEP> effect
<tb> LD50 / ED35
<tb> Phenylbutazon <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 942 <SEP> 13, <SEP> 6
<tb> A <SEP> 11 <SEP> 9, <SEP> 3 <SEP> 10, <SEP> 1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98, <SEP> 5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP>
<tb>
 

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<tb>
<tb> substance <SEP> mean value <SEP> ulcerogenic <SEP> effect <SEP> therapeutic <SEP> index
<tb> ED35
<tb> ED50 <SEP> (U)

   <SEP> Confidence range <SEP> at <SEP> ratio <SEP> between <SEP> ulcerogenic <SEP> and
<tb> mg / kg <SEP> 95% <SEP> probability <SEP> antiexudative <SEP> effect
<tb> mg / kg <SEP> ED50 <SEP> (U) / ED35 <SEP>
<tb> Phenylbutazone <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15.38 <SEP> - <SEP> 50.96 <SEP> 2, <SEP> 77
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15.88- <SEP> 45.90 <SEP> 2, <SEP> 71
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP >
<tb>
 

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Claims (1)

EMI8.3 <Desc/Clms Page number 9> EMI9.1 EMI9.2 EMI9.3 EMI8.3 <Desc / Clms Page number 9> EMI9.1 EMI9.2 EMI9.3
AT448775A 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT AT335435B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT448775A AT335435B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732341507 DE2341507A1 (en) 1973-08-16 1973-08-16 NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING
AT577674A AT331235B (en) 1973-08-16 1974-07-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT
AT448775A AT335435B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Publications (2)

Publication Number Publication Date
ATA448775A ATA448775A (en) 1976-07-15
AT335435B true AT335435B (en) 1977-03-10

Family

ID=27149983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT448775A AT335435B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT

Country Status (1)

Country Link
AT (1) AT335435B (en)

Also Published As

Publication number Publication date
ATA448775A (en) 1976-07-15

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Legal Events

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