AT335431B - PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS - Google Patents

PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Info

Publication number
AT335431B
AT335431B AT448075A AT448075A AT335431B AT 335431 B AT335431 B AT 335431B AT 448075 A AT448075 A AT 448075A AT 448075 A AT448075 A AT 448075A AT 335431 B AT335431 B AT 335431B
Authority
AT
Austria
Prior art keywords
sep
biphenylyl
amides
esters
salts
Prior art date
Application number
AT448075A
Other languages
German (de)
Other versions
ATA448075A (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732341507 external-priority patent/DE2341507A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to AT448075A priority Critical patent/AT335431B/en
Publication of ATA448075A publication Critical patent/ATA448075A/en
Application granted granted Critical
Publication of AT335431B publication Critical patent/AT335431B/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

  

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<tb> 
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  (4-Biphenylyl)-buttersauren, <SEP> deren <SEP> EsterSubstanz <SEP> Kaolinödem <SEP> Carrageeninödem <SEP> Mittelwert <SEP> akute <SEP> Toxizität <SEP> Ratte <SEP> Therapeut. <SEP> Index
<tb> ED35 <SEP> per <SEP> os <SEP> ED35 <SEP> per <SEP> os <SEP> ED35
<tb> mg/kg <SEP> mg/kg <SEP> mg <SEP> ! <SEP> kg <SEP> mg/kg <SEP> Vertr.

   <SEP> Grenzen <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> toxischer <SEP> 
<tb> 95%iger <SEP> Wahr- <SEP> und <SEP> antiexsudativer
<tb> scheinlichkeit <SEP> Wirkung
<tb> LD50 <SEP> / <SEP> ED35
<tb> Phenylbutazon <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 943 <SEP> 13,6
<tb> A <SEP> 11 <SEP> 9,3 <SEP> 10,1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98,5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 
<tb> 
 

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<tb> 
<tb> Substanz <SEP> Mittelwert <SEP> Ulcerogene <SEP> Wirkung <SEP> Therapeutischer <SEP> Index
<tb> ED35 <SEP> ED50 <SEP> (U)

   <SEP> Vertrauensbereich <SEP> bei <SEP> Verhältnis <SEP> zwischen <SEP> ulcerogener <SEP> und
<tb> mg/kg <SEP> 95%iger <SEP> Wahrscheinlichkeit <SEP> antiexsudativer <SEP> Wirkung
<tb> mg/kg <SEP> Ed <SEP> (U)/ED
<tb> 50 <SEP> 35
<tb> Phenylbutazon <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP> 
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, <SEP> 77
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15, <SEP> 88 <SEP> - <SEP> 45,90 <SEP> 2, <SEP> 71
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP> 
<tb> 
 

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**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



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  (4-biphenylyl) butyric acid, <SEP> their <SEP> ester substance <SEP> kaolin edema <SEP> carrageenin edema <SEP> mean value <SEP> acute <SEP> toxicity <SEP> rat <SEP> therapist. <SEP> index
<tb> ED35 <SEP> via <SEP> os <SEP> ED35 <SEP> via <SEP> os <SEP> ED35
<tb> mg / kg <SEP> mg / kg <SEP> mg <SEP>! <SEP> kg <SEP> mg / kg <SEP> rep.

   <SEP> limits <SEP> at <SEP> ratio <SEP> between <SEP> toxic <SEP>
<tb> 95% <SEP> true- <SEP> and <SEP> anti-exudative
<tb> probability <SEP> effect
<tb> LD50 <SEP> / <SEP> ED35
<tb> Phenylbutazone <SEP> 58 <SEP> 69 <SEP> 63, <SEP> 5 <SEP> 864 <SEP> 793 <SEP> - <SEP> 943 <SEP> 13.6
<tb> A <SEP> 11 <SEP> 9.3 <SEP> 10.1 <SEP> 970 <SEP> 740 <SEP> - <SEP> 1270 <SEP> 96
<tb> B <SEP> 10, <SEP> 5 <SEP> 9, <SEP> 4 <SEP> 9, <SEP> 95 <SEP> 980 <SEP> 649 <SEP> - <SEP> 1480 <SEP> 98.5
<tb> C <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP> 26, <SEP> 0 <SEP>
<tb>
 

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<tb>
<tb> substance <SEP> mean value <SEP> ulcerogenic <SEP> effect <SEP> therapeutic <SEP> index
<tb> ED35 <SEP> ED50 <SEP> (U)

   <SEP> Confidence range <SEP> at <SEP> ratio <SEP> between <SEP> ulcerogenic <SEP> and
<tb> mg / kg <SEP> 95% <SEP> probability <SEP> antiexudative <SEP> effect
<tb> mg / kg <SEP> Ed <SEP> (U) / ED
<tb> 50 <SEP> 35
<tb> Phenylbutazone <SEP> 63, <SEP> 5 <SEP> 106 <SEP> 1, <SEP> 67 <SEP>
<tb> A <SEP> 10, <SEP> 1 <SEP> 28, <SEP> 0 <SEP> 15, <SEP> 38 <SEP> - <SEP> 50, <SEP> 96 <SEP> 2, < SEP> 77
<tb> B <SEP> 9, <SEP> 95 <SEP> 27, <SEP> 0 <SEP> 15, <SEP> 88 <SEP> - <SEP> 45.90 <SEP> 2, <SEP> 71
<tb> C <SEP> 26 <SEP> 81, <SEP> 0 <SEP> 64, <SEP> 80 <SEP> - <SEP> 101, <SEP> 25 <SEP> 3, <SEP> 12 <SEP >
<tb>
 

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** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

EMI9.3 EMI9.4 EMI9.5 <Desc/Clms Page number 10> EMI10.1 EMI10.2 EMI10.3 EMI9.3 EMI9.4 EMI9.5 <Desc / Clms Page number 10> EMI10.1 EMI10.2 EMI10.3
AT448075A 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS AT335431B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT448075A AT335431B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19732341507 DE2341507A1 (en) 1973-08-16 1973-08-16 NEW BIPHENYL DERIVATIVES AND METHOD OF MANUFACTURING
AT577674A AT331235B (en) 1973-08-16 1974-07-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALT
AT448075A AT335431B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Publications (2)

Publication Number Publication Date
ATA448075A ATA448075A (en) 1976-07-15
AT335431B true AT335431B (en) 1977-03-10

Family

ID=27149974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT448075A AT335431B (en) 1973-08-16 1975-06-12 PROCESS FOR THE PREPARATION OF NEW 3- (4-BIPHENYLYL) BUTTER ACIDS, THEIR ESTERS, AMIDES AND SALTS

Country Status (1)

Country Link
AT (1) AT335431B (en)

Also Published As

Publication number Publication date
ATA448075A (en) 1976-07-15

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee