AT311967B - Process for the preparation of a new pyridoxine derivative - Google Patents

Process for the preparation of a new pyridoxine derivative

Info

Publication number
AT311967B
AT311967B AT103272A AT103272A AT311967B AT 311967 B AT311967 B AT 311967B AT 103272 A AT103272 A AT 103272A AT 103272 A AT103272 A AT 103272A AT 311967 B AT311967 B AT 311967B
Authority
AT
Austria
Prior art keywords
preparation
new
pyridoxine derivative
derivative
pyridoxine
Prior art date
Application number
AT103272A
Other languages
German (de)
Original Assignee
Made Labor Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Made Labor Sa filed Critical Made Labor Sa
Priority to AT103272A priority Critical patent/AT311967B/en
Application granted granted Critical
Publication of AT311967B publication Critical patent/AT311967B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Die Patentschrift Nr. 300810 betrifft ein Verfahren zur Herstellung neuer Pyridoxinderivate der Formel 
 EMI1.1 
 in der X ein Wasserstoffatom, ein Alkali- oder Erdalkalimetall oder eine organische Base ist. 



   Nach dem Verfahren des Stammpatentes erfolgt die Herstellung von Verbindungen der vorstehend angegebenen Formel (Pyridoxin-a-ketoglutarat) in der Weise, dass man Lösungen von vorzugsweise äquimolekularen Mengen von Pyridoxin und   cx-Ketoglutarsäure   bzw. deren Derivate in einem organischen oder anorganischen Lösungsmittel mischt und das Verfahrensprodukt in bekannter Weise fällt und aus dem Lösungsmittelgemisch aufnimmt. Nach dem Verfahren des Stammpatentes ist ferner vorgesehen, dass man die Lösungen unmittelbar vor dem Mischen herstellt und als Lösungsmittel Äthanol verwendet. 



   Vorliegende Erfindung betrifft in Weiterbildung der Erfindung des Stammpatentes ein Verfahren zur Herstellung einer Verbindung der Formel 
 EMI1.2 
 
 EMI1.3 




   <Desc / Clms Page number 1>
 



  Patent specification No. 300810 relates to a process for the preparation of new pyridoxine derivatives of the formula
 EMI1.1
 in which X is a hydrogen atom, an alkali or alkaline earth metal or an organic base.



   According to the method of the parent patent, compounds of the formula given above (pyridoxine-a-ketoglutarate) are prepared in such a way that solutions of preferably equimolecular amounts of pyridoxine and cx-ketoglutaric acid or their derivatives are mixed in an organic or inorganic solvent and the process product falls in a known manner and takes up from the solvent mixture. According to the method of the parent patent, it is also provided that the solutions are prepared immediately before mixing and that ethanol is used as the solvent.



   In a further development of the invention of the parent patent, the present invention relates to a method for producing a compound of the formula
 EMI1.2
 
 EMI1.3

Claims (1)

eines wasserlöslichen organischen Lösungsmittels fällt.PATENTANSPRUCH : Verfahren zur Herstellung eines neuen Pyridoxinderivates der Formel EMI2.1 da durch gekennzeichnet, dass man Pyridoxin-a-ketoglutarat und 5-Hydroxytryptophan in wässeriger Lösung umsetzt und das Reaktionsprodukt in bekannter Weise aufnimmt. of a water-soluble organic solvent. PATENT CLAIM: Process for the preparation of a new pyridoxine derivative of the formula EMI2.1 characterized in that pyridoxine-a-ketoglutarate and 5-hydroxytryptophan are reacted in aqueous solution and the reaction product is absorbed in a known manner.
AT103272A 1972-02-09 1972-02-09 Process for the preparation of a new pyridoxine derivative AT311967B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT103272A AT311967B (en) 1972-02-09 1972-02-09 Process for the preparation of a new pyridoxine derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT300810D
AT103272A AT311967B (en) 1972-02-09 1972-02-09 Process for the preparation of a new pyridoxine derivative

Publications (1)

Publication Number Publication Date
AT311967B true AT311967B (en) 1973-12-10

Family

ID=25594657

Family Applications (1)

Application Number Title Priority Date Filing Date
AT103272A AT311967B (en) 1972-02-09 1972-02-09 Process for the preparation of a new pyridoxine derivative

Country Status (1)

Country Link
AT (1) AT311967B (en)

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