AT218013B - Process for the preparation of the new 1-acetyl-1- (β-hydroxyethyl) -2- (5'-nitrofurfurylidene) hydrazine - Google Patents

Process for the preparation of the new 1-acetyl-1- (β-hydroxyethyl) -2- (5'-nitrofurfurylidene) hydrazine

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Publication number
AT218013B
AT218013B AT63461A AT63461A AT218013B AT 218013 B AT218013 B AT 218013B AT 63461 A AT63461 A AT 63461A AT 63461 A AT63461 A AT 63461A AT 218013 B AT218013 B AT 218013B
Authority
AT
Austria
Prior art keywords
hydroxyethyl
nitrofurfurylidene
hydrazine
acetyl
preparation
Prior art date
Application number
AT63461A
Other languages
German (de)
Original Assignee
Norwich Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Pharma Co filed Critical Norwich Pharma Co
Application granted granted Critical
Publication of AT218013B publication Critical patent/AT218013B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

  

   <Desc/Clms Page number 1> 
 
 EMI1.1 
 
Die Erfindung betrifft die Herstellung des neuen   l-Acetyl-l- (ss-hydroxyäthyl)-2- (5'-nitrofurfuryliden)-   hydrazins der Formel : 
 EMI1.2 
 
Diese Verbindung besitzt eine ausgezeichnete chemotherapeutische Wirksamkeit ; wie durch Versuche an Kücken bzw. Mäusen nachgewiesen werden konnte, ist sie insbesondere gegenüber Eimeria tenella und Staphylococcus aureus wirksam. Darüber hinaus ist die Verbindung ein wichtiges Zwischenprodukt zur Herstellung des ebenfalls chemotherapeutisch wirksamen 1-Acetyl-1-(ss-chloräthyl)-2-(5'-nitrofurfuryl-   iden)-hydrazins.   



   Das neue Nitrofuran-Derivat ist gut verträglich. Es lässt sich mit den üblichen   pbarmaceutischen   Trägersubstanzen und Adjuvantien zu Tabletten, Suspensionen, Kapseln usw. verarbeiten ; zur Behandlung von Tieren wird es in üblicher Weise mit dem Futter oder Trinkwasser vermischt. 
 EMI1.3 
 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 
 EMI1.1
 
The invention relates to the preparation of the new l-acetyl-l- (ss-hydroxyethyl) -2- (5'-nitrofurfurylidene) hydrazine of the formula:
 EMI1.2
 
This compound has excellent chemotherapeutic activity; As could be demonstrated by experiments on chicks and mice, it is particularly effective against Eimeria tenella and Staphylococcus aureus. In addition, the compound is an important intermediate for the preparation of 1-acetyl-1- (ss-chloroethyl) -2- (5'-nitrofurfurylidene) hydrazine, which is also chemotherapeutically active.



   The new nitrofuran derivative is well tolerated. It can be processed into tablets, suspensions, capsules, etc. with the usual pharmaceutical carrier substances and adjuvants; for the treatment of animals it is mixed in the usual way with the feed or drinking water.
 EMI1.3
 

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

(ss-hydroxyäthyl)-2- (5'-nitrofurfüryliden)-hydrazinsBeispiel : 107 g (0, 54 Mol) 5-Nitrofurfuryliden-ss-hydroxyäthyl-hydrazon werden in 750 cm3 Eisessig gelöst und 30 min. lang mit 55 g (0, 54 Mol) Essigsäureanhydrid auf 75-110 C erhitzt. Das Reaktionsgemisch EMI1.4 : 78 gPATENTANSPRUCH : Verfahren zur Herstellung des neuen 1-Acetyl-1-(ss-hydroxyäthyl)-2-(5'-nitrofurfuryliden)-hydrazins der Formel : EMI1.5 dadurch gekennzeichnet, dass man 5-Nitrofurfuryliden-ss-hydroxyäthyl-hydrazon mit Acetylierungsmitteln behandelt. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. (ss-hydroxyethyl) -2- (5'-nitrofurfürylidene) -hydrazines Example: 107 g (0.54 mol) of 5-nitrofurfurylidene-ß-hydroxyethyl hydrazone are dissolved in 750 cm3 of glacial acetic acid and 30 min. heated to 75-110 ° C. with 55 g (0.54 mol) of acetic anhydride for a long time. The reaction mixture EMI1.4 : 78 g PATENT CLAIM: Process for the preparation of the new 1-acetyl-1- (ss-hydroxyethyl) -2- (5'-nitrofurfurylidene) hydrazine of the formula: EMI1.5 characterized in that 5-nitrofurfurylidene-ss-hydroxyethyl hydrazone is treated with acetylating agents. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT63461A 1960-02-23 1961-01-25 Process for the preparation of the new 1-acetyl-1- (β-hydroxyethyl) -2- (5'-nitrofurfurylidene) hydrazine AT218013B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US218013XA 1960-02-23 1960-02-23

Publications (1)

Publication Number Publication Date
AT218013B true AT218013B (en) 1961-11-10

Family

ID=21806228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT63461A AT218013B (en) 1960-02-23 1961-01-25 Process for the preparation of the new 1-acetyl-1- (β-hydroxyethyl) -2- (5'-nitrofurfurylidene) hydrazine

Country Status (1)

Country Link
AT (1) AT218013B (en)

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