AR127437A1 - Nanopartículas, composiciones de vacunas, procedimientos, usos y métodos de administración - Google Patents

Nanopartículas, composiciones de vacunas, procedimientos, usos y métodos de administración

Info

Publication number
AR127437A1
AR127437A1 ARP220102879A ARP220102879A AR127437A1 AR 127437 A1 AR127437 A1 AR 127437A1 AR P220102879 A ARP220102879 A AR P220102879A AR P220102879 A ARP220102879 A AR P220102879A AR 127437 A1 AR127437 A1 AR 127437A1
Authority
AR
Argentina
Prior art keywords
nanoparticles
vaccine compositions
procedures
administration methods
tpp
Prior art date
Application number
ARP220102879A
Other languages
English (en)
Inventor
Guillermo Horacio Docena
Omar Azzaroni
Paola Lorena Smaldini
Gastn Pascual Rizzo
Santiago Esteban Herrera
Maximiliano Luis Agazzi
Camila Chavero
Daiana Bianchi
Waldemar Alejandro Marmisoll
Mara Lorena Cortez
Eugenia Apuzzo
Original Assignee
Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet
Univ Nacional De La Plata Unlp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet, Univ Nacional De La Plata Unlp filed Critical Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet
Priority to ARP220102879A priority Critical patent/AR127437A1/es
Priority to PCT/IB2023/060711 priority patent/WO2024089593A1/en
Publication of AR127437A1 publication Critical patent/AR127437A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Nanopartículas adyuvantes para vacunas que comprenden una relación molar entre TPP / PAH de 0,01 / 0,6, un diámetro entre 80 nm y 526 nm, una polidispersidad de diámetro entre 0,04 y 0,25 y un potencial Z de superficie entre +70 mV y -20 mV. La carga y el tamaño de las nanopartículas dependerán de la relación molar, concentración o cantidad de los compuestos TPP y PAH, del pH inicial del procedimiento, del medio en donde se lleve a cabo el procedimiento. Se muestran además, composiciones de vacunas en donde las nanopartículas encapsulan a los antígenos; y procedimientos de elaboración. Reivindicación 6: La composición de acuerdo con la reivindicación 5, caracterizadas porque comprende el antígeno RBD.
ARP220102879A 2022-10-24 2022-10-24 Nanopartículas, composiciones de vacunas, procedimientos, usos y métodos de administración AR127437A1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ARP220102879A AR127437A1 (es) 2022-10-24 2022-10-24 Nanopartículas, composiciones de vacunas, procedimientos, usos y métodos de administración
PCT/IB2023/060711 WO2024089593A1 (en) 2022-10-24 2023-10-24 Nanoparticles, vaccine compositions, procedures, uses, and methods of administration thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP220102879A AR127437A1 (es) 2022-10-24 2022-10-24 Nanopartículas, composiciones de vacunas, procedimientos, usos y métodos de administración

Publications (1)

Publication Number Publication Date
AR127437A1 true AR127437A1 (es) 2024-01-24

Family

ID=88757620

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220102879A AR127437A1 (es) 2022-10-24 2022-10-24 Nanopartículas, composiciones de vacunas, procedimientos, usos y métodos de administración

Country Status (2)

Country Link
AR (1) AR127437A1 (es)
WO (1) WO2024089593A1 (es)

Also Published As

Publication number Publication date
WO2024089593A1 (en) 2024-05-02

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