AR126114A1 - VARIANTES GENOMODIFICADAS DE LA NRG-1 CON UNA SELECTIVIDAD MEJORADA FRENTE AL ErbB4 PERO NO FRENTE AL ErbB3 - Google Patents
VARIANTES GENOMODIFICADAS DE LA NRG-1 CON UNA SELECTIVIDAD MEJORADA FRENTE AL ErbB4 PERO NO FRENTE AL ErbB3Info
- Publication number
- AR126114A1 AR126114A1 ARP220101527A ARP220101527A AR126114A1 AR 126114 A1 AR126114 A1 AR 126114A1 AR P220101527 A ARP220101527 A AR P220101527A AR P220101527 A ARP220101527 A AR P220101527A AR 126114 A1 AR126114 A1 AR 126114A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- variants
- genomodified
- erbb3
- nrg
- Prior art date
Links
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 title 1
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 title 1
- 101000653754 Rattus norvegicus Sphingosine 1-phosphate receptor 5 Proteins 0.000 title 1
- 102000056372 ErbB-3 Receptor Human genes 0.000 abstract 1
- 102000044591 ErbB-4 Receptor Human genes 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 102000014413 Neuregulin Human genes 0.000 abstract 1
- 108050003475 Neuregulin Proteins 0.000 abstract 1
- 102000048238 Neuregulin-1 Human genes 0.000 abstract 1
- 108090000556 Neuregulin-1 Proteins 0.000 abstract 1
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 abstract 1
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a variantes de la neurregulina-1 genomodificadas que activan selectivamente los receptores ErbB4 pero no activan los receptores ErbB3. La invención también proporciona métodos de uso de dichas variantes para tratar la insuficiencia cardíaca. Reivindicación 1: Una variante de la neurregulina que comprende una secuencia de aminoácidos de la fórmula: SHLVKCX¹⁸³EX¹⁸⁵X¹⁸⁶KX¹⁸⁸FCVNGGECX¹⁹⁷X¹⁹⁸X¹⁹⁹X²⁰⁰X²⁰¹X²⁰²SX²⁰⁴PSRX²⁰⁸LCKCPNEFTGDRCX²²²X²²³X²²⁴X²²⁵X²²⁶ASX²²⁹ (SEQ ID Nº 177) en donde X¹⁸³ es A o G; X¹⁸⁵X¹⁸⁶ es KD, KE, KH, ND, NE, NH, RD, RE, RH, RQ, SD, SE o SH; X¹⁸⁸ es S o T; X¹⁹⁷X¹⁹⁸X¹⁹⁹X²⁰⁰X²⁰¹X²⁰² es FMIEDS (SEQ ID Nº 178), FMIEGP (SEQ ID Nº 179), FMIEHL (SEQ ID Nº 180), FMVEDL (SEQ ID Nº 181), FMVERS (SEQ ID Nº 182), FMVKRP (SEQ ID Nº 183), FVIEDP (SEQ ID Nº 184), FVIEGS (SEQ ID Nº 185), FVVEGL (SEQ ID Nº 186), YMIEDL (SEQ ID Nº 187), YMIEGL (SEQ ID Nº 188), YMIEHP (SEQ ID Nº 189), YMVEDL (SEQ ID Nº 190), YMVEGS (SEQ ID Nº 191), YMVERP (SEQ ID Nº 192), YVIEDS (SEQ ID Nº 193), YVIEGS (SEQ ID Nº 194), YVIEHL (SEQ ID Nº 195), YVVEDL (SEQ ID Nº 196), YVVEHS (SEQ ID Nº 197) o YVVERP (SEQ ID Nº 198); X²⁰⁴ es I o N; X²⁰⁸ es F o Y; X²²²X²²³X²²⁴X²²⁵X²²⁶ es EKDVM (SEQ ID Nº 199), QAPHI (SEQ ID Nº 200), QDDFM (SEQ ID Nº 201), QDFFL (SEQ ID Nº 202), QDFFM (SEQ ID Nº 203), QDVFL (SEQ ID Nº 204), QDVFM (SEQ ID Nº 205), QEDFM (SEQ ID Nº 206), QETQI (SEQ ID Nº 207), QKDFL (SEQ ID Nº 208), QKDFM (SEQ ID Nº 209), QKDVM (SEQ ID Nº 210), QKFFL (SEQ ID Nº 211), QKFFM (SEQ ID Nº 212), QKLDI (SEQ ID Nº 213), QKTSL (SEQ ID Nº 214), QKVFL (SEQ ID Nº 215), QKVFM (SEQ ID Nº 216), QKVVM (SEQ ID Nº 217), QNDFL (SEQ ID Nº 218), QNDFM (SEQ ID Nº 219), QNVFL (SEQ ID Nº 220), QNVFM (SEQ ID Nº 221), QNYVM (SEQ ID Nº 222), QQSFP (SEQ ID Nº 223), QSALT (SEQ ID Nº 224), QSSEL (SEQ ID Nº 225), QSTRV (SEQ ID Nº 226), QTSLL (SEQ ID Nº 227) o QVTRL (SEQ ID Nº 228); y X²²⁹ está ausente, es F o FYKAEELYQ (SEQ ID Nº 229).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163209248P | 2021-06-10 | 2021-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126114A1 true AR126114A1 (es) | 2023-09-13 |
Family
ID=82492400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101527A AR126114A1 (es) | 2021-06-10 | 2022-06-09 | VARIANTES GENOMODIFICADAS DE LA NRG-1 CON UNA SELECTIVIDAD MEJORADA FRENTE AL ErbB4 PERO NO FRENTE AL ErbB3 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220402985A1 (es) |
| EP (1) | EP4351722A1 (es) |
| AR (1) | AR126114A1 (es) |
| AU (1) | AU2022289721A1 (es) |
| CA (1) | CA3222782A1 (es) |
| TW (1) | TW202306975A (es) |
| UY (1) | UY39807A (es) |
| WO (1) | WO2022261299A1 (es) |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US930A (en) | 1838-09-19 | Jordan l | ||
| US5716A (en) | 1848-08-15 | Valve of water-iiams | ||
| US1104741A (en) * | 1913-08-16 | 1914-07-21 | Nashua Card Gummed & Coated Paper Company | Paper-feeder. |
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| AU651596B2 (en) | 1990-06-05 | 1994-07-28 | Immunex Corporation | Type II interleukin-1 receptors |
| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
| US5607342A (en) * | 1995-03-27 | 1997-03-04 | Demeton Usa, Inc. | High velocity flame jet apparatus for thermoabrasive cutting or cleaning or for the application of protective coatings |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| DK0873405T3 (da) | 1996-01-11 | 2005-01-17 | Immunex Corp | Ekspressionsforøgende sekvenselementer (EASE) til eukaryote ekspressionssystemer |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6136558A (en) * | 1997-02-10 | 2000-10-24 | Genentech, Inc. | Heregulin variants |
| IL130827A0 (en) * | 1997-02-10 | 2001-01-28 | Genentech Inc | Heregulin variants |
| AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
| US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| US20080070838A1 (en) | 2004-09-13 | 2008-03-20 | University Of Southampton | Growth Factor Treatment for Asthma |
| CN101103045B (zh) | 2004-09-24 | 2015-11-25 | 安姆根有限公司 | 修饰的Fc分子 |
| US20070213264A1 (en) * | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
| WO2009007332A2 (de) | 2007-07-06 | 2009-01-15 | Markus Heller | Verfahren zum ermitteln von für die charakterisierung von gelenkbewegungen relevanten informationen |
| US20090156488A1 (en) | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| CN102232084B (zh) | 2008-11-28 | 2014-05-28 | 上海泽生科技开发有限公司 | 纽兰格林及其用途 |
-
2022
- 2022-06-09 UY UY0001039807A patent/UY39807A/es unknown
- 2022-06-09 WO PCT/US2022/032801 patent/WO2022261299A1/en active Application Filing
- 2022-06-09 AU AU2022289721A patent/AU2022289721A1/en active Pending
- 2022-06-09 AR ARP220101527A patent/AR126114A1/es unknown
- 2022-06-09 TW TW111121403A patent/TW202306975A/zh unknown
- 2022-06-09 CA CA3222782A patent/CA3222782A1/en active Pending
- 2022-06-09 US US17/836,425 patent/US20220402985A1/en active Pending
- 2022-06-09 EP EP22741092.5A patent/EP4351722A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3222782A1 (en) | 2022-12-15 |
| EP4351722A1 (en) | 2024-04-17 |
| WO2022261299A1 (en) | 2022-12-15 |
| US20220402985A1 (en) | 2022-12-22 |
| UY39807A (es) | 2022-12-30 |
| TW202306975A (zh) | 2023-02-16 |
| AU2022289721A1 (en) | 2024-01-04 |
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