AR124744A1 - AGENT FOR USE IN INDUCING SPECIFIC IMMUNITY AGAINST SARS-CoV-2 SEVERE ACUTE RESPIRATORY SYNDROME VIRUS IN SUBJECTS OVER 60 YEARS OF AGE AND/OR HAVING CHRONIC DISEASES (VARIANTS) - Google Patents
AGENT FOR USE IN INDUCING SPECIFIC IMMUNITY AGAINST SARS-CoV-2 SEVERE ACUTE RESPIRATORY SYNDROME VIRUS IN SUBJECTS OVER 60 YEARS OF AGE AND/OR HAVING CHRONIC DISEASES (VARIANTS)Info
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- AR124744A1 AR124744A1 ARP220100346A ARP220100346A AR124744A1 AR 124744 A1 AR124744 A1 AR 124744A1 AR P220100346 A ARP220100346 A AR P220100346A AR P220100346 A ARP220100346 A AR P220100346A AR 124744 A1 AR124744 A1 AR 124744A1
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
La invención se relaciona con el campo de biotecnología, inmunología y virología. Un agente para uso en la inducción de inmunidad específica contra el virus del síndrome respiratorio agudo severo SARS-CoV-2 en sujetos mayores de 60 años de edad y/o con enfermedades crónicas es divulgado, conteniendo dicho agente un componente 1, que es un agente en forma de vector de expresión basado en el genoma de una cepa recombinante de adenovirus humano de serotipo 26 con sitios E1 y E3 eliminados del genoma, y el sitio ORF6-Ad26 está sustituido por ORF6-Ad5 con un casete de expresión integrado seleccionado entre SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3, y/o que contiene un componente 2, que es un agente en forma de vector de expresión basado en el genoma de una cepa recombinante de adenovirus humano de serotipo 5 con sitios E1 y E3 eliminados del genoma con un casete de expresión integrado seleccionado entre SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3. Además, se divulga un agente para uso en la inducción de inmunidad específica contra el virus del síndrome respiratorio agudo severo SARS-CoV-2 en sujetos mayores de 60 años y/o que tengan enfermedades crónicas, conteniendo dicho agente un componente 1, que es un agente en forma de vector de expresión basado en el genoma de una cepa recombinante de adenovirus humano serotipo 26 con sitios E1 y E3 eliminados del genoma, y el sitio ORF6-Ad26 está sustituido por ORF6-Ad5 con un casete de expresión integrado seleccionado entre SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3, y que también contiene un componente 2, que es un agente en forma de vector de expresión basado en el genoma de una cepa recombinante de adenovirus de simio de serotipo 25 con sitios E1 y E3 eliminados del genoma con un casete de expresión integrado seleccionado entre SEQ ID Nº 4, SEQ ID Nº 2, SEQ ID Nº 3, o que contiene solo el componente 2. Además, se divulga un agente para uso en la inducción de inmunidad específica contra el síndrome respiratorio agudo severo SARS-CoV-2 en sujetos mayores de 60 años de edad y/o que tienen enfermedades crónicas, conteniendo dicho agente un componente 1, que es un agente en forma de vector de expresión basado en el genoma de una cepa recombinante de adenovirus de simio de serotipo 25 con sitios E1 y E3 eliminados del genoma con un casete de expresión integrado seleccionado entre SEQ ID Nº 4, SEQ ID Nº 2, SEQ ID Nº 3, y que también contiene un componente 2, que es un agente en forma de vector de expresión basado en el genoma de una cepa recombinante de adenovirus humano de serotipo 5 con sitios E1 y E3 eliminados del genoma con el casete de expresión integrado seleccionado de SEQ ID Nº 1, SEQ ID Nº 2, SEQ ID Nº 3. Las invenciones proporcionan inducción eficaz de la respuesta inmune contra el virus SARS-CoV-2 en sujetos mayores de 60 años de edad y que también tienen enfermedades crónicas.The invention relates to the field of biotechnology, immunology and virology. An agent for use in inducing specific immunity against the SARS-CoV-2 severe acute respiratory syndrome virus in subjects over 60 years of age and/or with chronic diseases is disclosed, said agent containing component 1, which is a agent in the form of an expression vector based on the genome of a recombinant strain of human adenovirus serotype 26 with E1 and E3 sites deleted from the genome, and the ORF6-Ad26 site is replaced by ORF6-Ad5 with an integrated expression cassette selected from SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and/or containing a component 2, which is an agent in the form of an expression vector based on the genome of a recombinant strain of human adenovirus serotype 5 with sites E1 and E3 deleted from the genome with an integrated expression cassette selected from SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3. Furthermore, an agent for use in inducing specific immunity against acute respiratory syndrome virus is disclosed. severe SARS-CoV-2 in subjects over 60 years of age and/or who have chronic diseases, said agent containing component 1, which is an agent in the form of an expression vector based on the genome of a recombinant strain of human adenovirus serotype 26 with E1 and E3 sites deleted from the genome, and the ORF6-Ad26 site is replaced by ORF6-Ad5 with an integrated expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and also containing a component 2, which is an agent in the form of an expression vector based on the genome of a serotype 25 recombinant strain of simian adenovirus with E1 and E3 sites deleted from the genome with an integrated expression cassette selected from SEQ ID No. 4, SEQ ID No. 2, SEQ ID No. 3, or containing only component 2. Furthermore, an agent is disclosed for use in inducing specific immunity against severe acute respiratory syndrome SARS-CoV-2 in subjects over 60 years of age and /or who have chronic diseases, said agent containing a component 1, which is an agent in the form of an expression vector based on the genome of a recombinant strain of serotype 25 simian adenovirus with E1 and E3 sites deleted from the genome with a cassette integrated expression agent selected from SEQ ID No. 4, SEQ ID No. 2, SEQ ID No. 3, and which also contains a component 2, which is an agent in the form of an expression vector based on the genome of a recombinant strain of human adenovirus of serotype 5 with E1 and E3 sites deleted from the genome with the integrated expression cassette selected from SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3. The inventions provide efficient induction of immune response against SARS-CoV-2 virus in subjects older than 60 years of age and who also have chronic diseases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2021104430A RU2744442C1 (en) | 2021-02-21 | 2021-02-21 | Use of agent for induction of specific immunity against severe acute respiratory syndrome sars-cov-2 for population revaccination in people over 60 and/or with chronic diseases (versions) |
Publications (1)
Publication Number | Publication Date |
---|---|
AR124744A1 true AR124744A1 (en) | 2023-05-03 |
Family
ID=74857783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220100346A AR124744A1 (en) | 2021-02-21 | 2022-02-18 | AGENT FOR USE IN INDUCING SPECIFIC IMMUNITY AGAINST SARS-CoV-2 SEVERE ACUTE RESPIRATORY SYNDROME VIRUS IN SUBJECTS OVER 60 YEARS OF AGE AND/OR HAVING CHRONIC DISEASES (VARIANTS) |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR124744A1 (en) |
RU (1) | RU2744442C1 (en) |
WO (1) | WO2022177465A1 (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110974950B (en) * | 2020-03-05 | 2020-08-07 | 广州恩宝生物医药科技有限公司 | Adenovirus vector vaccine for preventing SARS-CoV-2 infection |
CN111217917B (en) * | 2020-02-26 | 2020-10-23 | 康希诺生物股份公司 | Novel coronavirus SARS-CoV-2 vaccine and preparation method thereof |
RU2738081C1 (en) * | 2020-10-14 | 2020-12-07 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере зашиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Peptide immunogens and a vaccine composition against coronavirus infection covid-19 using peptide immunogens |
RU2743593C1 (en) * | 2020-12-09 | 2021-02-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Peptide immunogens and vaccine composition against covid-19 with the use of peptide immunogens |
RU2743595C1 (en) * | 2020-12-09 | 2021-02-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Vaccine composition against covid-19 |
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2021
- 2021-02-21 RU RU2021104430A patent/RU2744442C1/en active
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2022
- 2022-02-18 AR ARP220100346A patent/AR124744A1/en unknown
- 2022-02-18 WO PCT/RU2022/000045 patent/WO2022177465A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2022177465A1 (en) | 2022-08-25 |
RU2744442C1 (en) | 2021-03-09 |
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