AR123291A1 - Métodos para marcar células eucariotas de un organismo multicelular utilizando compuestos monosacáridos modificados - Google Patents
Métodos para marcar células eucariotas de un organismo multicelular utilizando compuestos monosacáridos modificadosInfo
- Publication number
- AR123291A1 AR123291A1 ARP210102336A ARP210102336A AR123291A1 AR 123291 A1 AR123291 A1 AR 123291A1 AR P210102336 A ARP210102336 A AR P210102336A AR P210102336 A ARP210102336 A AR P210102336A AR 123291 A1 AR123291 A1 AR 123291A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- eukaryotic cells
- monosaccharide
- modified monosaccharide
- multicellular organism
- Prior art date
Links
- -1 MONOSACCHARIDE COMPOUNDS Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 4
- 150000001875 compounds Chemical group 0.000 abstract 3
- 150000002772 monosaccharides Chemical class 0.000 abstract 2
- 230000004108 pentose phosphate pathway Effects 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Virology (AREA)
- Zoology (AREA)
Abstract
Reivindicación 1: Un método in vitro para marcar o detectar o direccionar una célula eucariota de un organismo multicelular, comprendiendo el método las etapas de: a) poner en contacto una muestra que comprende células eucariotas con al menos un compuesto monosacárido modificado de la ruta de las pentosas fosfato, excluyendo arabinosa; b) poner en contacto la muestra de la etapa (a) con un compuesto que lleva un primer grupo reactivo, opcionalmente en presencia de cobre; y c) opcionalmente detectar el compuesto de la etapa (b) unido al monosacárido de la etapa (a), de modo de detectar células eucariotas; en donde dicho al menos un compuesto monosacárido modificado de la ruta de las pentosas fosfato comprende un grupo reactivo X, denominado un segundo grupo reactivo, y en donde el primer y el segundo grupo reactivos son capaces de reaccionar juntos en una reacción química click, de modo de obtener el compuesto de la etapa (b) unido a dicho monosacárido. Reivindicación 10: Una composición farmacéutica que comprende una célula eucariota que presenta en su superficie al menos un compuesto monosacárido modificado de la ruta de las pentosas fosfato, como definido en una cualquiera de las reivindicaciones 1 a 7, opcionalmente ligado operativamente o no a una droga anticáncer o a partículas que comprenden una droga anticáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20305935 | 2020-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR123291A1 true AR123291A1 (es) | 2022-11-16 |
Family
ID=72517188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210102336A AR123291A1 (es) | 2020-08-19 | 2021-08-19 | Métodos para marcar células eucariotas de un organismo multicelular utilizando compuestos monosacáridos modificados |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240027435A1 (es) |
| EP (1) | EP4200614A1 (es) |
| JP (1) | JP2023538615A (es) |
| KR (1) | KR20230051566A (es) |
| CN (1) | CN115968446A (es) |
| AR (1) | AR123291A1 (es) |
| CA (1) | CA3188425A1 (es) |
| IL (1) | IL300488A (es) |
| TW (1) | TW202211925A (es) |
| WO (1) | WO2022038196A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101159172B1 (ko) | 2011-11-24 | 2012-08-07 | 학 성 김 | Id카드이용 선후불겸용결제 방법 및 시스템 |
| EP3091081A1 (en) | 2015-05-04 | 2016-11-09 | Centre National de la Recherche Scientifique (CNRS) | A method for labeling specifically living microorganisms comprising the use of modified monosaccharide compounds |
| US11014953B2 (en) * | 2015-10-07 | 2021-05-25 | The Board Of Trustees Of The University Of Illinois | Trigger-activatable metabolic sugar precursors for cancer-selective labeling and targeting |
| AU2017286715B2 (en) * | 2016-06-15 | 2022-03-03 | The General Hospital Corporation | Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions |
| CN113677997A (zh) * | 2019-02-20 | 2021-11-19 | 迪亚米德克斯 | 使用修饰的单糖化合物用于标记来自多细胞生物的真核细胞以及用于治疗和/或诊断癌症的方法 |
-
2021
- 2021-08-18 IL IL300488A patent/IL300488A/en unknown
- 2021-08-18 JP JP2023512182A patent/JP2023538615A/ja active Pending
- 2021-08-18 CA CA3188425A patent/CA3188425A1/en active Pending
- 2021-08-18 WO PCT/EP2021/072963 patent/WO2022038196A1/en active Application Filing
- 2021-08-18 CN CN202180050372.3A patent/CN115968446A/zh active Pending
- 2021-08-18 EP EP21765895.4A patent/EP4200614A1/en active Pending
- 2021-08-18 US US18/021,761 patent/US20240027435A1/en active Pending
- 2021-08-18 KR KR1020237009164A patent/KR20230051566A/ko active Search and Examination
- 2021-08-19 TW TW110130652A patent/TW202211925A/zh unknown
- 2021-08-19 AR ARP210102336A patent/AR123291A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230051566A (ko) | 2023-04-18 |
| JP2023538615A (ja) | 2023-09-08 |
| CA3188425A1 (en) | 2022-02-24 |
| IL300488A (en) | 2023-04-01 |
| EP4200614A1 (en) | 2023-06-28 |
| TW202211925A (zh) | 2022-04-01 |
| WO2022038196A1 (en) | 2022-02-24 |
| US20240027435A1 (en) | 2024-01-25 |
| CN115968446A (zh) | 2023-04-14 |
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