AR120324A1 - Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica - Google Patents
Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclicaInfo
- Publication number
- AR120324A1 AR120324A1 ARP200102980A ARP200102980A AR120324A1 AR 120324 A1 AR120324 A1 AR 120324A1 AR P200102980 A ARP200102980 A AR P200102980A AR P200102980 A ARP200102980 A AR P200102980A AR 120324 A1 AR120324 A1 AR 120324A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- cycloalkyl
- halo
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962927268P | 2019-10-29 | 2019-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR120324A1 true AR120324A1 (es) | 2022-02-09 |
Family
ID=73554493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200102980A AR120324A1 (es) | 2019-10-29 | 2020-10-28 | Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12565504B2 (enExample) |
| EP (1) | EP4051682A1 (enExample) |
| JP (1) | JP2023501949A (enExample) |
| CN (1) | CN114929709B (enExample) |
| AR (1) | AR120324A1 (enExample) |
| TW (1) | TW202130643A (enExample) |
| UY (1) | UY38934A (enExample) |
| WO (1) | WO2021086966A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022095971A1 (zh) * | 2020-11-06 | 2022-05-12 | 上海医药集团股份有限公司 | 一种螺杂环类化合物、其制备方法及应用 |
| WO2025247394A1 (zh) * | 2024-05-31 | 2025-12-04 | 纽欧申医药(上海)有限公司 | 含氮杂环化合物、其药物组合物及应用 |
| CN119569746B (zh) * | 2025-02-06 | 2025-05-13 | 纽欧申医药(上海)有限公司 | 含氮杂环化合物、其药物组合物及应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| EP1847542A1 (en) * | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
| ATE486877T1 (de) | 2006-12-29 | 2010-11-15 | Hoffmann La Roche | Azaspiroderivate |
| WO2010141074A2 (en) * | 2009-06-01 | 2010-12-09 | President And Fellows Of Harvard College | O-glcnac transferase inhibitors and uses thereof |
| AU2012298949B2 (en) * | 2011-08-25 | 2016-09-22 | Merck Patent Gmbh | Pyrano [3, 2 - D] [1, 3] thiazole as glycosidase inhibitors |
| US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP2780014A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| WO2013078320A1 (en) | 2011-11-21 | 2013-05-30 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP5989805B2 (ja) | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| MA38341B1 (fr) | 2013-02-11 | 2018-11-30 | Constellation Pharmaceuticals Inc | Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées |
| PT2970272T (pt) * | 2013-03-14 | 2019-06-05 | Merck Patent Gmbh | Inibidores de glicosidase |
| US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| NZ727185A (en) * | 2014-06-24 | 2018-04-27 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| CN107912040B (zh) * | 2014-10-10 | 2021-04-06 | 基因泰克公司 | 作为组蛋白脱甲基酶抑制剂的吡咯烷酰胺化合物 |
| SMT202100699T1 (it) * | 2016-06-16 | 2022-01-10 | Denali Therapeutics Inc | Pirimidin-2-ilammino-1h-pirazoli come inibitori di lrrk2 per l'uso nel trattamento di disturbi neurodegenerativi |
| US11186564B2 (en) * | 2016-08-04 | 2021-11-30 | Sunovion Pharmaceuticals Inc. | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders |
| AU2018216040A1 (en) | 2017-02-06 | 2019-06-20 | Janssen Pharmaceutica Nv | OGA inhibitor compounds |
-
2020
- 2020-10-28 AR ARP200102980A patent/AR120324A1/es unknown
- 2020-10-28 CN CN202080091113.0A patent/CN114929709B/zh active Active
- 2020-10-28 WO PCT/US2020/057740 patent/WO2021086966A1/en not_active Ceased
- 2020-10-28 US US17/772,646 patent/US12565504B2/en active Active
- 2020-10-28 EP EP20812162.4A patent/EP4051682A1/en not_active Withdrawn
- 2020-10-28 TW TW109137522A patent/TW202130643A/zh unknown
- 2020-10-28 UY UY0001038934A patent/UY38934A/es not_active Application Discontinuation
- 2020-10-28 JP JP2022525282A patent/JP2023501949A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021086966A1 (en) | 2021-05-06 |
| TW202130643A (zh) | 2021-08-16 |
| US12565504B2 (en) | 2026-03-03 |
| US20230060003A1 (en) | 2023-02-23 |
| CN114929709A (zh) | 2022-08-19 |
| EP4051682A1 (en) | 2022-09-07 |
| UY38934A (es) | 2021-05-31 |
| CN114929709B (zh) | 2024-08-30 |
| JP2023501949A (ja) | 2023-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |