AR112538A1 - Métodos para el tratamiento de distrofia muscular - Google Patents
Métodos para el tratamiento de distrofia muscularInfo
- Publication number
- AR112538A1 AR112538A1 ARP180102486A AR112538A1 AR 112538 A1 AR112538 A1 AR 112538A1 AR P180102486 A ARP180102486 A AR P180102486A AR 112538 A1 AR112538 A1 AR 112538A1
- Authority
- AR
- Argentina
- Prior art keywords
- muscular dystrophy
- methods
- treatment
- disclosure provides
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
Abstract
La presente descripción proporciona, entre otras cosas, composiciones y métodos mejorados para tratar la distrofia muscular. Por ejemplo, la descripción proporciona métodos para tratar pacientes con distrofia muscular de Duchenne que tienen una mutación en el gen DMD que es susceptible de omisión del exón 53 administrando una cantidad eficaz de golodirsen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762553094P | 2017-08-31 | 2017-08-31 | |
US201762565824P | 2017-09-29 | 2017-09-29 | |
US201862725129P | 2018-08-30 | 2018-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR112538A1 true AR112538A1 (es) | 2019-11-06 |
Family
ID=65526062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180102486 AR112538A1 (es) | 2017-08-31 | 2018-08-31 | Métodos para el tratamiento de distrofia muscular |
Country Status (15)
Country | Link |
---|---|
US (1) | US20230038956A1 (es) |
EP (1) | EP3675836A4 (es) |
JP (2) | JP2020532504A (es) |
KR (1) | KR20200046069A (es) |
CN (1) | CN111417388A (es) |
AR (1) | AR112538A1 (es) |
AU (1) | AU2018326780A1 (es) |
CA (1) | CA3073736A1 (es) |
CO (1) | CO2020004034A2 (es) |
IL (1) | IL272791A (es) |
MA (1) | MA50062A (es) |
MX (1) | MX2020002038A (es) |
SG (1) | SG11202001074RA (es) |
TW (1) | TW201919655A (es) |
WO (1) | WO2019046755A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
US20220296633A1 (en) * | 2019-06-19 | 2022-09-22 | Sarepta Therapeutics, Inc. | Methods for treating muscular dystrophy |
CN112430645A (zh) * | 2020-12-09 | 2021-03-02 | 北京华瑞康源生物科技发展有限公司 | 一种多重实时荧光pcr法检测人dmd基因拷贝数的相对定量方法及试剂盒 |
WO2023168427A1 (en) | 2022-03-03 | 2023-09-07 | Yale University | Compositions and methods for delivering therapeutic polynucleotides for exon skipping |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
HUE042218T2 (hu) * | 2013-03-14 | 2019-06-28 | Sarepta Therapeutics Inc | Exonátugrást elõsegítõ készítmények izomdisztrófia kezelésére |
BR112015022998A2 (pt) * | 2013-03-15 | 2017-11-14 | Sarepta Therapeutics Inc | composições melhoradas para o tratamento de distrofia muscular |
BR112018007066A2 (pt) * | 2015-10-09 | 2018-10-23 | Sarepta Therapeutics Inc | composições e métodos para tratamento da distrofia muscular de duchene e distúrbios relacionados |
-
2018
- 2018-08-31 KR KR1020207008557A patent/KR20200046069A/ko not_active Application Discontinuation
- 2018-08-31 CN CN201880056909.5A patent/CN111417388A/zh active Pending
- 2018-08-31 SG SG11202001074RA patent/SG11202001074RA/en unknown
- 2018-08-31 US US16/640,852 patent/US20230038956A1/en not_active Abandoned
- 2018-08-31 EP EP18851503.5A patent/EP3675836A4/en active Pending
- 2018-08-31 MA MA050062A patent/MA50062A/fr unknown
- 2018-08-31 JP JP2020511299A patent/JP2020532504A/ja not_active Withdrawn
- 2018-08-31 MX MX2020002038A patent/MX2020002038A/es unknown
- 2018-08-31 WO PCT/US2018/049151 patent/WO2019046755A1/en unknown
- 2018-08-31 AR ARP180102486 patent/AR112538A1/es unknown
- 2018-08-31 AU AU2018326780A patent/AU2018326780A1/en active Pending
- 2018-08-31 TW TW107130738A patent/TW201919655A/zh unknown
- 2018-08-31 CA CA3073736A patent/CA3073736A1/en active Pending
-
2020
- 2020-02-20 IL IL272791A patent/IL272791A/en unknown
- 2020-03-31 CO CONC2020/0004034A patent/CO2020004034A2/es unknown
-
2023
- 2023-08-14 JP JP2023131995A patent/JP2023138867A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2020002038A (es) | 2020-09-18 |
CO2020004034A2 (es) | 2020-04-24 |
JP2023138867A (ja) | 2023-10-02 |
CA3073736A1 (en) | 2019-03-07 |
TW201919655A (zh) | 2019-06-01 |
EP3675836A4 (en) | 2021-05-26 |
MA50062A (fr) | 2020-07-08 |
SG11202001074RA (en) | 2020-03-30 |
AU2018326780A1 (en) | 2020-02-27 |
IL272791A (en) | 2020-04-30 |
WO2019046755A1 (en) | 2019-03-07 |
EP3675836A1 (en) | 2020-07-08 |
KR20200046069A (ko) | 2020-05-06 |
JP2020532504A (ja) | 2020-11-12 |
US20230038956A1 (en) | 2023-02-09 |
CN111417388A (zh) | 2020-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2020004034A2 (es) | Métodos para el tratamiento de distrofia muscular | |
BR112018006445A2 (pt) | métodos para tratar distrofia muscular | |
CL2021001292A1 (es) | Terapia de combinación que incluye un inhibidor de krasg12c y uno o más agentes farmacéuticamente activos adicionales para el tratamiento de cánceres | |
CO2019006292A2 (es) | Composiciones de aminoácidos y métodos para el tratamiento de enfermedades y trastornos musculares | |
GT201700246A (es) | Métodos y kits para tratar la depresión | |
PH12017500746B1 (en) | Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease | |
MX2021000071A (es) | Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer. | |
AR101312A1 (es) | Combinaciones de inhibidores de bet e inhibidores de tirosina quinasa de bruton | |
CL2017000866A1 (es) | Compuestos y composiciones para el tratamiento o prevencion de trastornos patologicos asociados con exceso de deposicion de fibrina y/o formacion de trombos | |
BR112017026739A2 (pt) | compostos para uso no tratamento de distúrbios neuromusculares | |
MX2019003397A (es) | Metodos para tratar trastornos mitocondriales y metabolicos. | |
NZ631289A (en) | Improved compositions for treating muscular dystrophy | |
NZ759766A (en) | Use of lactic acid bacteria to treat or prevent at least one of postnatal depression and postnatal anxiety | |
BR112022007677A2 (pt) | L-asparaginase recombinante | |
AR101740A1 (es) | Terapia de combinación y composiciones | |
CO2021014024A2 (es) | Métodos para tratar la distrofia muscular con casimersin | |
BR112015018360A2 (pt) | terapia de combinação para o tratamento de pneumonia nosocomial | |
EA201692020A1 (ru) | Пролекарственные средства янтарной кислоты для применения в лечении лактоацидоза или индуцируемого лекарственными средствами побочного действия вследствие связанных с комплексом i нарушений окислительного фосфорилирования в митохондриях | |
MX2020004678A (es) | Uso de profarmacos de riluzol para tratar ataxias. | |
TW201613583A (en) | Laquinimod for the treatment of relapsing- remitting multiple sclerosis (RRMS) patients with a high disability status | |
CO2019014212A2 (es) | Métodos de tratamiento para la distonía cervical listado de secuencias | |
BR112017002449A2 (pt) | tratamento de sintomas associados com terapia de privação androgênica | |
AR118495A1 (es) | Métodos para tratar la distrofia muscular | |
CO2020006395A2 (es) | Régimen de dosificación de edasalonexent para el tratamiento de distrofia muscular | |
CO2021004612A2 (es) | Derivados de 4 pirazin 2 ilmetil-morfolina y su uso como medicamento |