AR106029A1 - DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE - Google Patents
DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUEInfo
- Publication number
- AR106029A1 AR106029A1 ARP160102806A ARP160102806A AR106029A1 AR 106029 A1 AR106029 A1 AR 106029A1 AR P160102806 A ARP160102806 A AR P160102806A AR P160102806 A ARP160102806 A AR P160102806A AR 106029 A1 AR106029 A1 AR 106029A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- mono
- dengue
- indol
- disabled
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 4
- 206010012310 Dengue fever Diseases 0.000 title abstract 4
- 208000025729 dengue disease Diseases 0.000 title abstract 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 150000002475 indoles Chemical class 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a compuestos indólicos mono o disustituidos, a métodos para prevenir o tratar infecciones virales por dengue utilizando dichos compuestos y también se refiere a dichos compuestos para su uso como una medicina, más preferentemente para su uso como una medicina para tratar o prevenir infecciones virales por dengue. La presente se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como una medicina, mas preferentemente para la prevención o el tratamiento de infecciones virales por dengue. También se refiere a procesos para la preparación de los compuestos. Reivindicación 1: Un compuesto de fórmula (1), una de sus formas estereoisoméricas, una de sus sales, solvatos o polimorfos farmacéuticamente aceptables que comprende un grupo indol mono- o disustituido; dicho compuesto se selecciona del grupo en el que: R¹ es H, R² es F, Cl o OCH₃ y R³ es H; R¹ es H, R² es F o Cl y R³ es CH₃; R¹ es CH₃, R² es OCH₃ y R³ es H; R¹ es F, R² es F y R³ es H; R¹ es CH₃, R² es F y R³ es H; R¹ es CF₃ o OCF₃ y R² es H y R³ es H; R¹ es OCF₃, R² es OCH₃ y R³ es H; o R¹ es OCF₃, R² es H y R³ es CH₃.This refers to mono or disubstituted indole compounds, methods to prevent or treat dengue viral infections using said compounds and also refers to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. This also relates to pharmaceutical compositions or combined preparations of the compounds, compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. It also refers to processes for the preparation of the compounds. Claim 1: A compound of formula (1), one of its stereoisomeric forms, one of its pharmaceutically acceptable salts, solvates or polymorphs comprising a mono- or disubstituted indole group; said compound is selected from the group in which: R¹ is H, R² is F, Cl or OCH₃ and R³ is H; R¹ is H, R² is F or Cl and R³ is CH₃; R¹ is CH₃, R² is OCH₃ and R³ is H; R¹ is F, R² is F and R³ is H; R¹ is CH₃, R² is F and R³ is H; R¹ is CF₃ or OCF₃ and R² is H and R³ is H; R¹ is OCF₃, R² is OCH₃ and R³ is H; or R¹ is OCF₃, R² is H and R³ is CH₃.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185523 | 2015-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106029A1 true AR106029A1 (en) | 2017-12-06 |
Family
ID=54207297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102806A AR106029A1 (en) | 2015-09-16 | 2016-09-14 | DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR106029A1 (en) |
| MY (1) | MY197383A (en) |
-
2016
- 2016-09-14 AR ARP160102806A patent/AR106029A1/en unknown
- 2016-09-15 MY MYPI2018000381A patent/MY197383A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY197383A (en) | 2023-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP22023220A (en) | MONO OR DISUBSTITUTED INDOL DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATION | |
| CO2018003369A2 (en) | Indole mono- or disubstituted derivatives as inhibitors of dengue viral replication | |
| CO2018009996A2 (en) | Compounds derived from indole substituted as inhibitors of dengue viral replication | |
| ECSP18073245A (en) | INHIBITORS OF INHIBITORS OF INHIBITORS OF VIRAL REPLICATION OF DENGUE | |
| CO2018003471A2 (en) | Indole mono- or disubstituted derivatives as inhibitors of dengue viral replication | |
| AR108046A1 (en) | INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE | |
| CO2018008421A2 (en) | Indoline derivatives substituted as inhibitors of dengue viral replication | |
| AR111315A1 (en) | INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE DENGUE VIRIC REPLICATION | |
| CL2017001822A1 (en) | Mono or disubstituted indole derivatives as inhibitors of dengue virus replication | |
| AR111878A1 (en) | INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE DENGUE VIRIC REPLICATION | |
| UY36124A (en) | CARBOXAMIDE DERIVATIVES | |
| AR120158A2 (en) | SUBSTITUTED INDOL MONO OR DI DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATION | |
| AR106029A1 (en) | DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE | |
| AR102135A1 (en) | MONKEY OR DISABLED INDOLES AS INHIBITORS OF THE DENGUE VIRUS REPLICATION | |
| AR106038A1 (en) | DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE | |
| CU20160170A7 (en) | CARBOXAMIDE DERIVATIVES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |