AR106029A1 - DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE - Google Patents
DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUEInfo
- Publication number
- AR106029A1 AR106029A1 ARP160102806A ARP160102806A AR106029A1 AR 106029 A1 AR106029 A1 AR 106029A1 AR P160102806 A ARP160102806 A AR P160102806A AR P160102806 A ARP160102806 A AR P160102806A AR 106029 A1 AR106029 A1 AR 106029A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- mono
- dengue
- indol
- disabled
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a compuestos indólicos mono o disustituidos, a métodos para prevenir o tratar infecciones virales por dengue utilizando dichos compuestos y también se refiere a dichos compuestos para su uso como una medicina, más preferentemente para su uso como una medicina para tratar o prevenir infecciones virales por dengue. La presente se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como una medicina, mas preferentemente para la prevención o el tratamiento de infecciones virales por dengue. También se refiere a procesos para la preparación de los compuestos. Reivindicación 1: Un compuesto de fórmula (1), una de sus formas estereoisoméricas, una de sus sales, solvatos o polimorfos farmacéuticamente aceptables que comprende un grupo indol mono- o disustituido; dicho compuesto se selecciona del grupo en el que: R¹ es H, R² es F, Cl o OCH₃ y R³ es H; R¹ es H, R² es F o Cl y R³ es CH₃; R¹ es CH₃, R² es OCH₃ y R³ es H; R¹ es F, R² es F y R³ es H; R¹ es CH₃, R² es F y R³ es H; R¹ es CF₃ o OCF₃ y R² es H y R³ es H; R¹ es OCF₃, R² es OCH₃ y R³ es H; o R¹ es OCF₃, R² es H y R³ es CH₃.This refers to mono or disubstituted indole compounds, methods to prevent or treat dengue viral infections using said compounds and also refers to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. This also relates to pharmaceutical compositions or combined preparations of the compounds, compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. It also refers to processes for the preparation of the compounds. Claim 1: A compound of formula (1), one of its stereoisomeric forms, one of its pharmaceutically acceptable salts, solvates or polymorphs comprising a mono- or disubstituted indole group; said compound is selected from the group in which: R¹ is H, R² is F, Cl or OCH₃ and R³ is H; R¹ is H, R² is F or Cl and R³ is CH₃; R¹ is CH₃, R² is OCH₃ and R³ is H; R¹ is F, R² is F and R³ is H; R¹ is CH₃, R² is F and R³ is H; R¹ is CF₃ or OCF₃ and R² is H and R³ is H; R¹ is OCF₃, R² is OCH₃ and R³ is H; or R¹ is OCF₃, R² is H and R³ is CH₃.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185523 | 2015-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106029A1 true AR106029A1 (en) | 2017-12-06 |
Family
ID=54207297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160102806A AR106029A1 (en) | 2015-09-16 | 2016-09-14 | DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR106029A1 (en) |
| MY (1) | MY197383A (en) |
-
2016
- 2016-09-14 AR ARP160102806A patent/AR106029A1/en unknown
- 2016-09-15 MY MYPI2018000381A patent/MY197383A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY197383A (en) | 2023-06-15 |
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