AR106038A1 - DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE - Google Patents

DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE

Info

Publication number
AR106038A1
AR106038A1 ARP160102817A ARP160102817A AR106038A1 AR 106038 A1 AR106038 A1 AR 106038A1 AR P160102817 A ARP160102817 A AR P160102817A AR P160102817 A ARP160102817 A AR P160102817A AR 106038 A1 AR106038 A1 AR 106038A1
Authority
AR
Argentina
Prior art keywords
mono
dengue
indol
disabled
inhibitors
Prior art date
Application number
ARP160102817A
Other languages
Spanish (es)
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of AR106038A1 publication Critical patent/AR106038A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto de fórmula (1), una de sus formas estereoisoméricas, una de sus sales, solvatos o polimorfos farmacéuticamente aceptables que comprende un grupo indol mono- o disustituido; donde dicho compuesto se selecciona a partir del grupo en el que: R¹ es H, R² es F o Cl y R³ es H o CH₃; R¹ es F, R² es F y R³ es H; R¹ es CH₃, R² es OCH₃ y R³ es H; R¹ es CH₃, R² es F y R³ es H; R¹ es CH₃, R² es H y R³ es F; R¹ es Cl, R² es H y R³ es CH₃; R¹ es OCF₃, R² es H o OCH₃ y R³ es H; y R¹ es OCF₃, R² es H y R³ es CH₃.Claim 1: A compound of formula (1), one of its stereoisomeric forms, one of its pharmaceutically acceptable salts, solvates or polymorphs comprising a mono- or disubstituted indole group; wherein said compound is selected from the group in which: R¹ is H, R² is F or Cl and R³ is H or CH₃; R¹ is F, R² is F and R³ is H; R¹ is CH₃, R² is OCH₃ and R³ is H; R¹ is CH₃, R² is F and R³ is H; R¹ is CH₃, R² is H and R³ is F; R¹ is Cl, R² is H and R³ is CH₃; R¹ is OCF₃, R² is H or OCH₃ and R³ is H; and R¹ is OCF₃, R² is H and R³ is CH₃.

ARP160102817A 2015-09-16 2016-09-15 DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE AR106038A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15185522 2015-09-16

Publications (1)

Publication Number Publication Date
AR106038A1 true AR106038A1 (en) 2017-12-06

Family

ID=54251290

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102817A AR106038A1 (en) 2015-09-16 2016-09-15 DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE

Country Status (1)

Country Link
AR (1) AR106038A1 (en)

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