AR102135A1 - MONKEY OR DISABLED INDOLES AS INHIBITORS OF THE DENGUE VIRUS REPLICATION - Google Patents
MONKEY OR DISABLED INDOLES AS INHIBITORS OF THE DENGUE VIRUS REPLICATIONInfo
- Publication number
- AR102135A1 AR102135A1 ARP150103152A ARP150103152A AR102135A1 AR 102135 A1 AR102135 A1 AR 102135A1 AR P150103152 A ARP150103152 A AR P150103152A AR P150103152 A ARP150103152 A AR P150103152A AR 102135 A1 AR102135 A1 AR 102135A1
- Authority
- AR
- Argentina
- Prior art keywords
- dengue virus
- compounds
- indoles
- monkey
- disabled
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La presente se refiere a compuestos de indol mono o disustituidos, métodos para prevenir o tratar infecciones por el virus del dengue mediante el uso de dichos compuestos y al uso de dichos compuestos como medicamento, más preferiblemente a su uso como un medicamento para tratar o prevenir infecciones por el virus del dengue. La presente se refiere además a composiciones farmacéuticas o preparaciones a partir de combinación de compuestos y a composiciones o preparados para uso como medicamento, más preferiblemente para la prevención o tratamiento de infecciones por el virus del dengue. También se refiere a los procesos de preparación de los compuestos. Reivindicación 1: Un compuesto de fórmula (1), una forma estereoisomérica, una sal, un solvato o un polimorfo farmacéuticamente aceptables de este, que comprende un grupo indol mono o disustituido; dicho compuesto se selecciona de un grupo donde R¹ es H, R² es F y R³ es H, F o CH₃; R¹ es F o CH₃, R² es OCH₃ y R³ es H; R¹ es H, R² es Cl y R³ es H o CH₃; R¹ es F, R² es H y R³ es CH₃; R¹ es H, R² es OCH₃ y R³ es Cl; R¹ es F, R² es F y R³ es H; R¹ es H, R² es OCH₃ y R³ es CH₃; o R¹ es CH₃, R² es H y R³ es F.This refers to mono or disubstituted indole compounds, methods for preventing or treating dengue virus infections through the use of said compounds and the use of said compounds as a medicament, more preferably for use as a medicament for treating or preventing Dengue virus infections. This also relates to pharmaceutical compositions or preparations from a combination of compounds and compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue virus infections. It also refers to the processes of preparation of the compounds. Claim 1: A compound of formula (1), a stereoisomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof, comprising a mono or disubstituted indole group; said compound is selected from a group where R¹ is H, R² is F and R³ is H, F or CH₃; R¹ is F or CH₃, R² is OCH₃ and R³ is H; R¹ is H, R² is Cl and R³ is H or CH₃; R¹ is F, R² is H and R³ is CH₃; R¹ is H, R² is OCH₃ and R³ is Cl; R¹ is F, R² is F and R³ is H; R¹ is H, R² is OCH₃ and R³ is CH₃; or R¹ is CH₃, R² is H and R³ is F.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14187373 | 2014-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102135A1 true AR102135A1 (en) | 2017-02-08 |
Family
ID=51743264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103152A AR102135A1 (en) | 2014-10-01 | 2015-09-30 | MONKEY OR DISABLED INDOLES AS INHIBITORS OF THE DENGUE VIRUS REPLICATION |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR102135A1 (en) |
-
2015
- 2015-09-30 AR ARP150103152A patent/AR102135A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR108046A1 (en) | INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE | |
| ECSP22023220A (en) | MONO OR DISUBSTITUTED INDOL DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATION | |
| CL2017000782A1 (en) | Mono- or disubstituted indole derivatives as inhibitors of dengue virus replication | |
| CL2017000742A1 (en) | Mono or disubstituted Indoles as inhibitors of dengue virus replication | |
| ECSP18073245A (en) | INHIBITORS OF INHIBITORS OF INHIBITORS OF VIRAL REPLICATION OF DENGUE | |
| AR111314A1 (en) | INDOLINA DERIVATIVES REPLACED AS INHIBITORS OF THE DENGUE VIRIC REPLICATION | |
| CL2017001822A1 (en) | Mono or disubstituted indole derivatives as inhibitors of dengue virus replication | |
| CL2018002784A1 (en) | Derivatives of substituted indole compounds as inhibitors of dengue viral replication. | |
| CO2018008421A2 (en) | Indoline derivatives substituted as inhibitors of dengue viral replication | |
| CO2018003369A2 (en) | Indole mono- or disubstituted derivatives as inhibitors of dengue viral replication | |
| CO2018003471A2 (en) | Indole mono- or disubstituted derivatives as inhibitors of dengue viral replication | |
| CR20190447A (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
| DOP2016000254A (en) | PHARMECEUTIC FORMULATIONS OF PAN-RAF QUINASE INHIBITOR, PROCEDURES FOR THEIR PREPARATION, AND METHODS OF USE. | |
| UY36124A (en) | CARBOXAMIDE DERIVATIVES | |
| UY36123A (en) | CARBOXAMIDE DERIVATIVES | |
| AR120158A2 (en) | SUBSTITUTED INDOL MONO OR DI DERIVATIVES AS INHIBITORS OF DENGUE VIRAL REPLICATION | |
| AR102135A1 (en) | MONKEY OR DISABLED INDOLES AS INHIBITORS OF THE DENGUE VIRUS REPLICATION | |
| AR106029A1 (en) | DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE VIRAL REPLICATION OF DENGUE | |
| AR102136A1 (en) | DERIVATIVES OF INDOL MONO- OR DISABLED AS INHIBITORS OF THE REPLICATION OF THE DENGUE VIRUS | |
| CU20160170A7 (en) | CARBOXAMIDE DERIVATIVES | |
| AR105921A1 (en) | THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS OF THESE |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |