AR099950A1 - Determinación de polimorfismos de un solo nucleótido de utilidad para la predicción de la respuesta a la rasagilina - Google Patents
Determinación de polimorfismos de un solo nucleótido de utilidad para la predicción de la respuesta a la rasagilinaInfo
- Publication number
- AR099950A1 AR099950A1 ARP150101010A ARP150101010A AR099950A1 AR 099950 A1 AR099950 A1 AR 099950A1 AR P150101010 A ARP150101010 A AR P150101010A AR P150101010 A ARP150101010 A AR P150101010A AR 099950 A1 AR099950 A1 AR 099950A1
- Authority
- AR
- Argentina
- Prior art keywords
- subject
- rasagiline
- parkinson
- disease
- human
- Prior art date
Links
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 title abstract 8
- 229960000245 rasagiline Drugs 0.000 title abstract 8
- 239000002773 nucleotide Substances 0.000 title abstract 5
- 102000054765 polymorphisms of proteins Human genes 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 9
- 239000012472 biological sample Substances 0.000 abstract 5
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 239000000523 sample Substances 0.000 abstract 4
- 239000003937 drug carrier Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Método para tratar un humano sujeto que sufre del mal de Parkinson (PD) con una composición farmacéutica que comprende rasagilina, o una sal farmacéuticamente aceptable de rasagilina, y un vehículo farmacéuticamente aceptable, que comprende los pasos de: (i) obtener una muestra biológica que comprende un genoma del sujeto humano que sufre de mal de Parkinson; (ii) evaluar el ADN o el ARN de la muestra biológica de dicho sujeto humano usando una sonda o un cebador, para determinar el genotipo diploide del sujeto del polimorfismo de un solo nucleótido (SNP) rs1076560 o rs2283265; (iii) identificar el sujeto humano como un respondedor predicho a la rasagilina si el genotipo diploide es CC en rs1076560, CC en rs2283265 o CC en ambos rs1076560 y rs2283265; y (iv) administrar la composición farmacéutica que comprende rasagilina y un vehículo farmacéuticamente aceptable al sujeto humano si dicho sujeto es identificado como un respondedor a la rasagilina. Reivindicación 31: Un conjunto de elementos [kit] de diagnóstico para evaluar la capacidad de respuesta al tratamiento con rasagilina en un sujeto humano que sufre del mal de Parkinson, caracterizado porque dicho conjunto de elementos comprende (i) por lo menos una sonda especifica del SNP rs1076560 o rs2283265, y (ii) instrucciones de uso de dicha por lo menos una sonda a fin de evaluar la capacidad de respuesta del sujeto al tratamiento con rasagilina. Reivindicación 39: Un método para determinar la identidad de los alelos de menos de 10.000 polimorfismos de un solo nucleótido (SNP) en un sujeto seleccionado del grupo de sujetos que consiste en sujetos humanos diagnosticados con el mal de Parkinson para producir un perfil polimórfico del sujeto seleccionado, diagnosticado con el mal de Parkinson, caracterizado porque comprende (i) obtener una muestra biológica que comprende un genoma del sujeto humano seleccionado que fue diagnosticado con el mal de Parkinson; (ii) seleccionar mediante un análisis de identidad alélica por lo menos un SNP ubicado en rs1076560 y un SNP ubicado en rs2283265 en el genoma del sujeto seleccionado que fue diagnosticado con el mal de Parkinson; y (iii) evaluar, con una sonda o un cebador, si a) la identidad alélica en rs1076560 es CC en la secuencia de nucleótidos del genoma en la muestra biológica del paso i), y b) la identidad alélica en rs2283265 es CC en la secuencia de nucleótidos del genoma en la muestra biológica del paso i), y en donde se seleccionaron menos de 10.000 SNP para el análisis de identidad alélica en el paso ii) y los mismos menos de 10.000 SNP se evalúan en el paso iii). Reivindicación 51: Una base de datos física o electrónica, caracterizada porque comprende los perfiles polimórficos de sujetos humanos que sufren de PD, en donde cada perfil polimórfico incluye el genotipo diploide de menos de 10.000 SNP, y dichos menos de 10.000 SNP incluyen rs1076560 y rs36023.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461973603P | 2014-04-01 | 2014-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR099950A1 true AR099950A1 (es) | 2016-08-31 |
Family
ID=54189487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150101010A AR099950A1 (es) | 2014-04-01 | 2015-04-01 | Determinación de polimorfismos de un solo nucleótido de utilidad para la predicción de la respuesta a la rasagilina |
Country Status (9)
Country | Link |
---|---|
US (1) | US20150275302A1 (es) |
EP (1) | EP3126527A4 (es) |
JP (1) | JP2017517481A (es) |
AR (1) | AR099950A1 (es) |
CA (1) | CA2943841A1 (es) |
IL (1) | IL247824A0 (es) |
MX (1) | MX2016012718A (es) |
TW (1) | TW201621051A (es) |
WO (1) | WO2015153629A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017087735A1 (en) * | 2015-11-18 | 2017-05-26 | Millennium Pharmaceuticals, Inc. | Method for treating crohn's disease |
CN107941953A (zh) * | 2017-11-30 | 2018-04-20 | 天津生机集团股份有限公司 | 一种兽药中金刚烷胺药物残留的检测方法 |
CN109825572A (zh) * | 2019-03-13 | 2019-05-31 | 陈向东 | 一种检测与异丙酚的敏感性相关基因多态性的试剂盒及其检测方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090253585A1 (en) * | 2005-11-30 | 2009-10-08 | Luda Diatchenko | Identification of Genetic Polymorphic Variants Associated With Somatosensory Disorders and Methods of Using the Same |
EP2069541A4 (en) * | 2006-08-01 | 2010-05-19 | Univ Ohio State Res Found | POLYMORPHISMS IN GENES AFFECTING DISORDERS OF THE CENTRAL NERVOUS SYSTEM AND USES THEREOF |
NZ589445A (en) * | 2008-06-13 | 2013-06-28 | Teva Pharma | Rasagiline for parkinson's disease modification |
US8835111B2 (en) * | 2009-03-12 | 2014-09-16 | Brainco Biopharma S.L. | Genotyping tool for improving the prognostic and clinical management of MS patients |
-
2015
- 2015-03-31 US US14/674,606 patent/US20150275302A1/en not_active Abandoned
- 2015-03-31 WO PCT/US2015/023618 patent/WO2015153629A1/en active Application Filing
- 2015-03-31 JP JP2016559825A patent/JP2017517481A/ja active Pending
- 2015-03-31 EP EP15773661.2A patent/EP3126527A4/en not_active Withdrawn
- 2015-03-31 MX MX2016012718A patent/MX2016012718A/es unknown
- 2015-03-31 CA CA2943841A patent/CA2943841A1/en not_active Abandoned
- 2015-04-01 TW TW104110766A patent/TW201621051A/zh unknown
- 2015-04-01 AR ARP150101010A patent/AR099950A1/es unknown
-
2016
- 2016-09-14 IL IL247824A patent/IL247824A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2943841A1 (en) | 2015-10-08 |
MX2016012718A (es) | 2016-12-16 |
US20150275302A1 (en) | 2015-10-01 |
WO2015153629A1 (en) | 2015-10-08 |
EP3126527A4 (en) | 2017-10-04 |
EP3126527A1 (en) | 2017-02-08 |
TW201621051A (zh) | 2016-06-16 |
JP2017517481A (ja) | 2017-06-29 |
IL247824A0 (en) | 2016-11-30 |
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