AR089703A1 - Derivados de arilamida que tienen propiedades antiandrogenicas - Google Patents

Derivados de arilamida que tienen propiedades antiandrogenicas

Info

Publication number
AR089703A1
AR089703A1 ARP130100091A ARP130100091A AR089703A1 AR 089703 A1 AR089703 A1 AR 089703A1 AR P130100091 A ARP130100091 A AR P130100091A AR P130100091 A ARP130100091 A AR P130100091A AR 089703 A1 AR089703 A1 AR 089703A1
Authority
AR
Argentina
Prior art keywords
derivatives
arilamide
trifluoromethyl
hydrogen
formula
Prior art date
Application number
ARP130100091A
Other languages
English (en)
Original Assignee
Medeia Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medeia Therapeutics Ltd filed Critical Medeia Therapeutics Ltd
Publication of AR089703A1 publication Critical patent/AR089703A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Los derivados de arilamida de la fórmula (1) tienen propiedades antiandrogénicas. La presente también se refiere a los compuestos de la fórmula (1) para utilizar como un medicamento y a composiciones farmacéuticas que los comprenden y a su preparación. Reivindicación 1: Un derivado de arilamida que tiene la fórmula (1) y estereoisómeros y sales farmacéuticamente aceptables de los mismos; donde R² es halo o trifluorometilo; y R⁸ y R⁹ se seleccionan del grupo que consta de hidrógeno, halo y trifluorometilo, siempre que al menos uno de R⁸ y R⁹ sea distinto de hidrógeno; y R¹¹ es alquilo C₃₋₅ ramificado o cicloalquilo C₃₋₆; siempre que cuando R¹¹ es isopentilo, R² es trifluorometilo y R⁹ es hidrógeno, luego R⁸ no es flúor.
ARP130100091A 2012-01-13 2013-01-11 Derivados de arilamida que tienen propiedades antiandrogenicas AR089703A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20125041 2012-01-13

Publications (1)

Publication Number Publication Date
AR089703A1 true AR089703A1 (es) 2014-09-10

Family

ID=47678880

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130100091A AR089703A1 (es) 2012-01-13 2013-01-11 Derivados de arilamida que tienen propiedades antiandrogenicas

Country Status (3)

Country Link
AR (1) AR089703A1 (es)
TW (1) TW201332953A (es)
WO (1) WO2013104831A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016079521A1 (en) * 2014-11-20 2016-05-26 University College Cardiff Consultants Limited Androgen receptor modulators and their use as anti-cancer agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100172B1 (en) 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide derivatives
AU2007275736A1 (en) 2006-07-19 2008-01-24 Osurf (Ohio State University Research Foundation) Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
ITBO20090078A1 (it) 2009-02-13 2010-08-14 Consiglio Nazionale Ricerche Composti per il trattamento del tumore alla prostata e procedimenti per la loro sintesi
EP2424853B1 (en) 2009-04-10 2018-09-19 Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (I.R.S.T.) S.R.L. Non-steroidal compounds for androgen receptor modulation, processes for the preparation and uses thereof
FI20105806A0 (fi) * 2010-07-15 2010-07-15 Medeia Therapeutics Ltd Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia

Also Published As

Publication number Publication date
WO2013104831A1 (en) 2013-07-18
TW201332953A (zh) 2013-08-16

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