AR079129A1 - Compuestos inhibidores de la hepatitis c - Google Patents

Compuestos inhibidores de la hepatitis c

Info

Publication number
AR079129A1
AR079129A1 ARP100104320A ARP100104320A AR079129A1 AR 079129 A1 AR079129 A1 AR 079129A1 AR P100104320 A ARP100104320 A AR P100104320A AR P100104320 A ARP100104320 A AR P100104320A AR 079129 A1 AR079129 A1 AR 079129A1
Authority
AR
Argentina
Prior art keywords
compounds
hepatitis
genotype
inhibiting compounds
contain
Prior art date
Application number
ARP100104320A
Other languages
English (en)
Inventor
Benoit Moreau
Cedrickx Godbout
Melissa Leblanc
Montse Llinas-Brunet
Josee Bordeleau
Jeffrey O'meara
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR079129A1 publication Critical patent/AR079129A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

Compuestos que son análogos de péptidos macrocíclicos que contienen un resto acilsulfonamida, mantienen actividad frente a las proteasas NS3 que contienen mutaciones de resistencia clínicamente relevantes para esta clase como se representa por las mutaciones de resistencia R155K de genotipo 1 a, D168V de genotipo 1b y D168V de genotipo 1a. Los compuestos son utiles como inhibidores de la proteasa NS3 de VHC para el tratamiento de una infeccion por el virus de la hepatitis C. Reivindicacion 1: Un compuesto caracterizado porque se selecciona del grupo que consiste en los compuestos de formulas 1001 a 1029 o una sal de este.
ARP100104320A 2009-11-24 2010-11-23 Compuestos inhibidores de la hepatitis c AR079129A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26406709P 2009-11-24 2009-11-24

Publications (1)

Publication Number Publication Date
AR079129A1 true AR079129A1 (es) 2011-12-28

Family

ID=44065771

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104320A AR079129A1 (es) 2009-11-24 2010-11-23 Compuestos inhibidores de la hepatitis c

Country Status (6)

Country Link
US (1) US20120077737A1 (es)
EP (1) EP2504343A4 (es)
JP (1) JP2013511561A (es)
AR (1) AR079129A1 (es)
TW (1) TW201129370A (es)
WO (1) WO2011063501A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
CA2822556A1 (en) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc Macrocyclic hepatitis c serine protease inhibitors
PE20140039A1 (es) 2010-12-30 2014-03-01 Enanta Pharm Inc Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US20140100364A1 (en) * 2012-10-08 2014-04-10 Abbvie Inc. Compounds Useful For Making HCV Protease Inhibitors
MA37992B1 (fr) 2012-10-19 2018-09-28 Bristol Myers Squibb Co Composes inhibiteurs de protéase ns3 pour une utilisation dans le traitement de l’infection par le virus de l'hépatite c.
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914613B1 (en) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR101535093B1 (ko) * 2013-12-30 2015-07-10 풍림유화공업(주) 트리스(히드록시메틸)포스핀의 제조방법
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6867185B2 (en) * 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US20050159345A1 (en) * 2002-10-29 2005-07-21 Boehringer Ingelheim International Gmbh Composition for the treatment of infection by Flaviviridae viruses
CN1856502A (zh) * 2003-09-22 2006-11-01 贝林格尔.英格海姆国际有限公司 抗c型肝炎病毒活性的巨环肽
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c

Also Published As

Publication number Publication date
JP2013511561A (ja) 2013-04-04
EP2504343A4 (en) 2013-04-17
EP2504343A1 (en) 2012-10-03
TW201129370A (en) 2011-09-01
US20120077737A1 (en) 2012-03-29
WO2011063501A1 (en) 2011-06-03

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