AR073058A1 - Combinaciones de imidazol sustituido. - Google Patents
Combinaciones de imidazol sustituido.Info
- Publication number
- AR073058A1 AR073058A1 ARP090103145A ARP090103145A AR073058A1 AR 073058 A1 AR073058 A1 AR 073058A1 AR P090103145 A ARP090103145 A AR P090103145A AR P090103145 A ARP090103145 A AR P090103145A AR 073058 A1 AR073058 A1 AR 073058A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- hydrogen
- alkylene
- independently hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicacion 1: Una composicion que comprende una cantidad eficaz de a) un compuesto de formula 1), o una sal o profármaco farmacéutica o veterinariamente aceptable del mismo en la que R1, R2, R3, R4, R5 son cada uno independientemente hidrogeno, halo, alquilo C1-4, alcoxi C1-4 o haloalquilo C1-4; R6 es hidrogeno, -alquileno C0-2R7, -alquileno C1-2OR7, -alquileno C1-2OC(O)R7, -alquileno C1-2OC(O)OR7 o -alquileno C0-2C(O)OR7; R7 es hidrogeno, alquilo C1-6 o alquileno C1-4-cicloalquilo C3-6; R8 y R9 son cada uno independientemente hidrogeno o alquilo C1-4, con la condicion que R8 y R9 no sean ambos hidrogeno; y R11 y R12 son cada uno independientemente hidrogeno, alquilo C1-2 o alcoxi C1-2; y b) una cantidad eficaz de un compuesto de formula (10) o una sal o profármaco farmacéutica o veterinariamente aceptable del mismo, en la que R1 es ciano o metilo; R2 es S(O)nR3; R3 es alquilo C1-6 o haloalquilo C1-6; R4 es NH2; R5 y R6 son cada uno independientemente hidrogeno, alquilo C1-6, haloalquilo C1-6, C(O)alquilo C1-6 o -S(O)rCF3; R7es alquilo C1-6 o haloalquilo C1-6; R8 es hidrogeno, alquilo C1-6 o haloalquilo C1-6; R9 es hidrogeno o alquilo C1-6, R11 y R12 son cada uno independientemente hidrogeno o halo; R13 es halo, haloalquilo C1-6, haloalcoxi C1-6, S(O)qCF3 o SF5, n, q y r son cada uno independientemente los numeros enteros 0, 1 o 2; y X es N o C-R12; con la condicion de que cuando R1 es metilo, entonces R3 sea haloalquilo C1-6, R11 sea cloro, R13 sea CF3 y X sea N, y opcionalmente c) un regulador del crecimiento de insectos que imita las hormonas juveniles, y un diluyente o vehículo farmacéutica o veterinariamente aceptable. Reivindicacion 3: Un procedimiento para la prevencion, tratamiento o control de garrapatas, pulgas y ácaros en mamíferos que comprende administrar a dicho mamífero una cantidad efectiva de una composicion de la reivindicacion 1. Reivindicacion 15: La composicion de la reivindicacion 1, 6 o 13 para uso como medicamento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8981508P | 2008-08-18 | 2008-08-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR073058A1 true AR073058A1 (es) | 2010-10-13 |
Family
ID=41667406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103145A AR073058A1 (es) | 2008-08-18 | 2009-08-14 | Combinaciones de imidazol sustituido. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20100041712A1 (es) |
EP (1) | EP2320732A2 (es) |
JP (2) | JP2010043084A (es) |
KR (1) | KR20110033934A (es) |
CN (1) | CN102123588B (es) |
AR (1) | AR073058A1 (es) |
AU (1) | AU2009283835B2 (es) |
BR (1) | BRPI0916970A2 (es) |
CA (1) | CA2731068A1 (es) |
MX (1) | MX2011001830A (es) |
NZ (1) | NZ590544A (es) |
WO (1) | WO2010020896A2 (es) |
ZA (1) | ZA201102049B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2784718A1 (en) * | 2010-01-29 | 2011-08-04 | Pfizer Inc. | Topical antiparasitic formulations |
WO2013074892A1 (en) | 2011-11-17 | 2013-05-23 | Merial Limited | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof |
WO2017194716A1 (en) * | 2016-05-12 | 2017-11-16 | Astrazeneca Ab | Inhibitors of protease-activated receptor-2 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4604971A (en) * | 1983-04-13 | 1986-08-12 | Aeci Limited | Insecticidal grooming article |
US5232940A (en) * | 1985-12-20 | 1993-08-03 | Hatton Leslie R | Derivatives of N-phenylpyrazoles |
US4862832A (en) * | 1987-02-27 | 1989-09-05 | Ciba-Geigy Corporation | Dispenser for the application of active components |
JP3715994B2 (ja) * | 1993-12-21 | 2005-11-16 | 住友化学株式会社 | 害虫防除剤 |
IE80657B1 (en) * | 1996-03-29 | 1998-11-04 | Merial Sas | Insecticidal combination to control mammal fleas in particular fleas on cats and dogs |
FR2761232B1 (fr) * | 1997-03-26 | 2000-03-10 | Rhone Merieux | Procede et moyens d'eradication des puces dans les locaux habites par les petits mammiferes |
US6103733A (en) * | 1998-09-09 | 2000-08-15 | Bachmann; Kenneth A. | Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes |
US7531186B2 (en) * | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
EP1735284A1 (en) * | 2004-03-18 | 2006-12-27 | Pfizer Limited | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
US7592362B2 (en) * | 2006-01-19 | 2009-09-22 | Pfizer Limited | Substituted imidazoles |
DE102006061538A1 (de) * | 2006-12-27 | 2008-07-03 | Bayer Healthcare Ag | Kombinationsprodukt zur Bekämpfung von Parasiten an Tieren |
-
2009
- 2009-06-25 US US12/491,507 patent/US20100041712A1/en not_active Abandoned
- 2009-08-04 MX MX2011001830A patent/MX2011001830A/es active IP Right Grant
- 2009-08-04 BR BRPI0916970-9A patent/BRPI0916970A2/pt not_active IP Right Cessation
- 2009-08-04 CA CA2731068A patent/CA2731068A1/en not_active Abandoned
- 2009-08-04 AU AU2009283835A patent/AU2009283835B2/en not_active Withdrawn - After Issue
- 2009-08-04 EP EP09786800A patent/EP2320732A2/en not_active Withdrawn
- 2009-08-04 KR KR1020117003671A patent/KR20110033934A/ko not_active Application Discontinuation
- 2009-08-04 NZ NZ590544A patent/NZ590544A/en not_active IP Right Cessation
- 2009-08-04 WO PCT/IB2009/053390 patent/WO2010020896A2/en active Application Filing
- 2009-08-04 CN CN2009801322480A patent/CN102123588B/zh not_active Expired - Fee Related
- 2009-08-14 AR ARP090103145A patent/AR073058A1/es not_active Application Discontinuation
- 2009-08-14 JP JP2009187981A patent/JP2010043084A/ja not_active Withdrawn
-
2011
- 2011-03-17 ZA ZA2011/02049A patent/ZA201102049B/en unknown
-
2012
- 2012-08-08 JP JP2012175979A patent/JP2012224639A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA201102049B (en) | 2011-11-30 |
NZ590544A (en) | 2011-11-25 |
BRPI0916970A2 (pt) | 2015-07-28 |
EP2320732A2 (en) | 2011-05-18 |
JP2010043084A (ja) | 2010-02-25 |
AU2009283835B2 (en) | 2012-08-16 |
US20100041712A1 (en) | 2010-02-18 |
AU2009283835A1 (en) | 2010-02-25 |
CN102123588B (zh) | 2013-10-23 |
MX2011001830A (es) | 2011-04-04 |
CN102123588A (zh) | 2011-07-13 |
JP2012224639A (ja) | 2012-11-15 |
WO2010020896A2 (en) | 2010-02-25 |
WO2010020896A3 (en) | 2011-01-13 |
KR20110033934A (ko) | 2011-04-01 |
CA2731068A1 (en) | 2010-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |