AR070733A1 - Derivados de platino-carbeno n-heterociclico, su preparacion, su composicion farmaceutica y su uso para el tratamiento del cancer - Google Patents
Derivados de platino-carbeno n-heterociclico, su preparacion, su composicion farmaceutica y su uso para el tratamiento del cancerInfo
- Publication number
- AR070733A1 AR070733A1 ARP090100729A ARP090100729A AR070733A1 AR 070733 A1 AR070733 A1 AR 070733A1 AR P090100729 A ARP090100729 A AR P090100729A AR P090100729 A ARP090100729 A AR P090100729A AR 070733 A1 AR070733 A1 AR 070733A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- group
- derivatives
- heterociclico
- carbene
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004474 heteroalkylene group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente se refiere a los derivados de platino N-heterociclo, de formula general (1) en la que R1 y/o R2 representan independientemente uno del otro un grupo arilo o aralquilo, cada uno opcionalmente sustituido, un grupo alquilo C1-6 lineal o ramificado, cicloalquilo monociclico C3-7, alquenilo C2-6 lineal o ramificado, o bien R' representa un átomo de hidrogeno y R representa un grupo elegido entre los grupos cicloalquilo, heterocicloalquilo, mono o bicíclico de C3-8 o bencilo opcionalmente sustituido o bien R y R' forman junto con NH un heterocicloalquilo mono o bicíclico C3-8; V representa un átomo de nitrogeno o un radical C-R4; R3 y/o R4 representan hidrogeno, un grupo fenilo o R3 y R4 pueden formar también juntos un radical alquileno C3-6, heteroalquileno C3-6 con uno o varios heteroátomos nitrogenados, pudiendo estar modificados en forma de radical carbonilo los átomos de carbono del radical heteroalquileno; X representa iodo, bromo, cloro o un grupo nitrato (-ONO2).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0801155A FR2928151B1 (fr) | 2008-03-03 | 2008-03-03 | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070733A1 true AR070733A1 (es) | 2010-04-28 |
Family
ID=39739698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100729A AR070733A1 (es) | 2008-03-03 | 2009-03-02 | Derivados de platino-carbeno n-heterociclico, su preparacion, su composicion farmaceutica y su uso para el tratamiento del cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8481522B2 (es) |
| EP (1) | EP2268652B1 (es) |
| JP (1) | JP5385923B2 (es) |
| AR (1) | AR070733A1 (es) |
| CL (1) | CL2009000502A1 (es) |
| FR (1) | FR2928151B1 (es) |
| TW (1) | TW200944199A (es) |
| UY (1) | UY31689A1 (es) |
| WO (1) | WO2009118475A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2928151B1 (fr) * | 2008-03-03 | 2010-12-31 | Sanofi Aventis | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
| US8168794B2 (en) | 2008-03-03 | 2012-05-01 | Novartis Ag | Pim kinase inhibitors and methods of their use |
| EP2493896B1 (en) * | 2009-10-28 | 2017-04-26 | The University of Hong Kong | Pharmaceutical composition containing cyclometalated n-heterocyclic carbene complexes for cancer treatment |
| FR2969615B1 (fr) * | 2010-12-23 | 2013-10-25 | Centre Nat Rech Scient | Nouveau complexes carbeniques de platine et leur utilisation comme medicaments |
| FR2969616B1 (fr) * | 2010-12-23 | 2013-01-11 | Centre Nat Rech Scient | Procede de preparation de complexes carbeniques de platine |
| CN102206226B (zh) * | 2011-04-14 | 2013-10-23 | 天津师范大学 | 三甲基苯连接的氮杂环卡宾金属配合物及其制备方法 |
| US9173883B2 (en) | 2012-05-21 | 2015-11-03 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
| CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
| WO2016004324A1 (en) * | 2014-07-02 | 2016-01-07 | University Of Florida Research Foundation, Inc. | Aptamer conjugates with n-heterocyclic carbene metal complexes for targeted drug delivery |
| CN106008609B (zh) * | 2016-05-31 | 2018-11-06 | 安徽大学 | 一种环金属铂配合物及其制备方法 |
| CN108689939A (zh) * | 2017-04-07 | 2018-10-23 | 厦门华绰生物医药科技有限公司 | 取代咪唑盐类化合物、其制备方法、药用组合物及其应用 |
| CN114375294B (zh) * | 2019-09-19 | 2024-06-28 | 香港大学 | 用于探测错配的dna的颜色可调的发光二齿铂(ii)配合物 |
| EP4232453A1 (en) | 2020-10-20 | 2023-08-30 | Institut Curie | Metallic trans-(n-heterocyclic carbene)-amine-platinum complexes and uses thereof for treating cancer |
| CN116143842A (zh) * | 2023-01-10 | 2023-05-23 | 广西师范大学 | 氧化异阿朴菲生物碱与n-杂环卡宾的环金属铱配合物及其合成方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4447066A1 (de) * | 1994-12-29 | 1996-07-04 | Hoechst Ag | Heterocyclische Carbene enthaltende Metallkomplexverbindungen |
| FR2825707B1 (fr) | 2001-06-07 | 2004-11-26 | Rhodia Chimie Sa | Procede de preparation de catalyseurs metalliques a base de carbenes, pour l'hydrosilylation de composes insatures et catalyseurs de ce type |
| FR2928151B1 (fr) * | 2008-03-03 | 2010-12-31 | Sanofi Aventis | Derives platine-carbene n-heterocyclique, leur preparation et leur application en therapeutique |
-
2008
- 2008-03-03 FR FR0801155A patent/FR2928151B1/fr not_active Expired - Fee Related
-
2009
- 2009-03-02 EP EP09724326A patent/EP2268652B1/fr active Active
- 2009-03-02 JP JP2010549173A patent/JP5385923B2/ja not_active Expired - Fee Related
- 2009-03-02 AR ARP090100729A patent/AR070733A1/es not_active Application Discontinuation
- 2009-03-02 WO PCT/FR2009/000220 patent/WO2009118475A2/fr active Application Filing
- 2009-03-03 UY UY031689A patent/UY31689A1/es not_active Application Discontinuation
- 2009-03-03 CL CL2009000502A patent/CL2009000502A1/es unknown
- 2009-03-03 TW TW098106864A patent/TW200944199A/zh unknown
-
2010
- 2010-09-02 US US12/874,815 patent/US8481522B2/en not_active Expired - Fee Related
-
2013
- 2013-06-21 US US13/923,540 patent/US8980875B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20130338128A1 (en) | 2013-12-19 |
| EP2268652B1 (fr) | 2012-12-19 |
| UY31689A1 (es) | 2009-09-30 |
| WO2009118475A3 (fr) | 2009-11-19 |
| US8481522B2 (en) | 2013-07-09 |
| EP2268652A2 (fr) | 2011-01-05 |
| US20110172199A1 (en) | 2011-07-14 |
| JP5385923B2 (ja) | 2014-01-08 |
| FR2928151B1 (fr) | 2010-12-31 |
| FR2928151A1 (fr) | 2009-09-04 |
| CL2009000502A1 (es) | 2010-03-05 |
| JP2011513373A (ja) | 2011-04-28 |
| TW200944199A (en) | 2009-11-01 |
| US8980875B2 (en) | 2015-03-17 |
| WO2009118475A2 (fr) | 2009-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |