AR068813A1 - DERIVATIVES OF PIRAZOL REPLACED AS ANTAGONISTS OF THE ANDROGEN RECEIVER (AR), A PHARMACEUTICAL AGENT THAT UNDERSTANDS AND USES THEMSELVES IN THE TREATMENT OF PROSTATE CANCER - Google Patents

DERIVATIVES OF PIRAZOL REPLACED AS ANTAGONISTS OF THE ANDROGEN RECEIVER (AR), A PHARMACEUTICAL AGENT THAT UNDERSTANDS AND USES THEMSELVES IN THE TREATMENT OF PROSTATE CANCER

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Publication number
AR068813A1
AR068813A1 ARP080103710A ARP080103710A AR068813A1 AR 068813 A1 AR068813 A1 AR 068813A1 AR P080103710 A ARP080103710 A AR P080103710A AR P080103710 A ARP080103710 A AR P080103710A AR 068813 A1 AR068813 A1 AR 068813A1
Authority
AR
Argentina
Prior art keywords
atom
group linked
pirazol
understands
antagonists
Prior art date
Application number
ARP080103710A
Other languages
Spanish (es)
Inventor
Mitsuhiro Ito
Tomohiko Suzaki
Satoshi Yamamoto
Original Assignee
Takeda Pharmaceutical
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Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR068813A1 publication Critical patent/AR068813A1/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Un derivado de pirazol y un antagonista del receptor de androgeno que contiene el derivado. Se proporciona un compuesto representado por la formula (1) en donde R1 es un átomo de hidrogeno, un grupo unido a través de un átomo de carbono, un grupo unido a través de un átomo de nitrogeno, un grupo unido a través de un átomo de oxígeno, o un grupo unido a través de un átomo de azufre; R2 es un grupo fenilo que tiene ciano (el grupo fenilo además puede tener sustituyente(s) diferentes de ciano); R3 es un átomo de hidrogeno, un grupo unido a través de un átomo de carbono, un grupo unido a través de un átomo de nitrogeno, un grupo unido a través de un átomo de oxígeno, o un grupo unido a través de un átomo de azufre; R4 es un grupo cíclico que opcionalmente tiene sustituyente(s); y X es metileno que opcionalmente tiene sustituyente(s), o CO; o una de sus sales.A pyrazole derivative and an androgen receptor antagonist that contains the derivative. A compound represented by the formula (1) is provided in which R 1 is a hydrogen atom, a group linked through a carbon atom, a group linked through a nitrogen atom, a group linked through an atom of oxygen, or a group linked through a sulfur atom; R2 is a phenyl group having cyano (the phenyl group may also have substituents (s) other than cyano); R3 is a hydrogen atom, a group linked through a carbon atom, a group linked through a nitrogen atom, a group linked through an oxygen atom, or a group linked through an atom of sulfur; R4 is a cyclic group that optionally has substituent (s); and X is methylene which optionally has substituent (s), or CO; or one of its salts.

ARP080103710A 2007-08-30 2008-08-27 DERIVATIVES OF PIRAZOL REPLACED AS ANTAGONISTS OF THE ANDROGEN RECEIVER (AR), A PHARMACEUTICAL AGENT THAT UNDERSTANDS AND USES THEMSELVES IN THE TREATMENT OF PROSTATE CANCER AR068813A1 (en)

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JP2007224910 2007-08-30

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AR068813A1 true AR068813A1 (en) 2009-12-09

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US (2) US20100227846A1 (en)
EP (1) EP2194045A4 (en)
JP (1) JPWO2009028543A1 (en)
KR (1) KR20100046275A (en)
CN (1) CN101842357A (en)
AR (1) AR068813A1 (en)
AU (1) AU2008292429A1 (en)
BR (1) BRPI0816095A2 (en)
CA (1) CA2697663A1 (en)
CL (1) CL2008002521A1 (en)
CO (1) CO6190530A2 (en)
DO (1) DOP2010000068A (en)
EA (1) EA201070323A1 (en)
EC (1) ECSP10010060A (en)
MA (1) MA31714B1 (en)
MX (1) MX2010002266A (en)
PE (1) PE20090610A1 (en)
TN (1) TN2010000091A1 (en)
TW (1) TW200913993A (en)
WO (1) WO2009028543A1 (en)

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US20100227846A1 (en) 2010-09-09
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CN101842357A (en) 2010-09-22
TN2010000091A1 (en) 2011-09-26
WO2009028543A1 (en) 2009-03-05
JPWO2009028543A1 (en) 2010-12-02
KR20100046275A (en) 2010-05-06
EP2194045A1 (en) 2010-06-09
AU2008292429A1 (en) 2009-03-05
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TW200913993A (en) 2009-04-01
MA31714B1 (en) 2010-09-01
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CA2697663A1 (en) 2009-03-05

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