AR064776A1 - Metodo para determinar la estabilidad de metilenamidas organicas en presencia de amina oxidasa sensible a semicarbazida - Google Patents
Metodo para determinar la estabilidad de metilenamidas organicas en presencia de amina oxidasa sensible a semicarbazidaInfo
- Publication number
- AR064776A1 AR064776A1 ARP080100060A ARP080100060A AR064776A1 AR 064776 A1 AR064776 A1 AR 064776A1 AR P080100060 A ARP080100060 A AR P080100060A AR P080100060 A ARP080100060 A AR P080100060A AR 064776 A1 AR064776 A1 AR 064776A1
- Authority
- AR
- Argentina
- Prior art keywords
- test agent
- ssao
- cells
- sensitive
- oxidase
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Abstract
Se proporciona métodos para determinar la estabilidad de metilenamina, compuestos similares a metilenamina o compuestos que contienen un resto metilenamina en presencia de anima oxidasa sensible a semicarbazida (SSAO) o una muestra biologica que contiene actividad de SSAO. Los métodos descritos se pueden configurar en un formato de ensayo para aplicaciones de seleccion de alto rendimiento. Reivindicacion 1: Un método de identificar la estabilidad metabolica de un agente de ensayo debida al metabolismo catalizado por amina oxidasa sensible a semicarbazida (SSAO), comprendiendo el método: a) cultivar células que expresen SSAO; b) anadir un agente de ensayo a las células; c) incubar el agente de ensayo con las células durante un periodo de tiempo predeterminado; d) medir la cantidad del agente de ensayo remanente en presencia de las células que comprende SSAO expresada en el periodo de tiempo predeterminado; y e) comparar la cantidad del agente de ensayo en el periodo de tiempo predeterminado con la cantidad de agente de ensayo en un control para determinar un valor, en donde el valor identifica la estabilidad metabolica del agente de ensayo en presencia de células que comprenden SSAO expresada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88426307P | 2007-01-10 | 2007-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064776A1 true AR064776A1 (es) | 2009-04-22 |
Family
ID=39361382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100060A AR064776A1 (es) | 2007-01-10 | 2008-01-08 | Metodo para determinar la estabilidad de metilenamidas organicas en presencia de amina oxidasa sensible a semicarbazida |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US20100028895A1 (es) |
| EP (1) | EP2121964A1 (es) |
| JP (2) | JP2010515461A (es) |
| KR (1) | KR20090107533A (es) |
| CN (1) | CN101578375B (es) |
| AR (1) | AR064776A1 (es) |
| AU (1) | AU2008204923A1 (es) |
| BR (1) | BRPI0806321A2 (es) |
| CA (1) | CA2674704A1 (es) |
| CR (1) | CR10862A (es) |
| DO (1) | DOP2009000175A (es) |
| EC (1) | ECSP099507A (es) |
| GT (1) | GT200900199A (es) |
| HK (1) | HK1137784A1 (es) |
| HN (1) | HN2009001289A (es) |
| IL (1) | IL199707A0 (es) |
| MA (1) | MA31226B1 (es) |
| MX (1) | MX2009005962A (es) |
| MY (1) | MY152893A (es) |
| NI (1) | NI200900132A (es) |
| NO (1) | NO20092816L (es) |
| NZ (1) | NZ578079A (es) |
| RU (1) | RU2009130380A (es) |
| SG (1) | SG177920A1 (es) |
| SV (1) | SV2009003327A (es) |
| TN (1) | TN2009000232A1 (es) |
| TW (1) | TW200907065A (es) |
| UA (1) | UA103300C2 (es) |
| WO (1) | WO2008086325A1 (es) |
| ZA (1) | ZA200903897B (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2289903A1 (en) | 1997-05-23 | 1998-11-26 | Oy Biotie Therapies, Ltd. | Vascular adhesion protein-1 having amine oxidase activity |
| KR101085210B1 (ko) | 1998-03-20 | 2011-11-21 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | 유전자 발현 조절방법 |
| WO1999049973A1 (de) * | 1998-03-27 | 1999-10-07 | Aventis Pharma Deutschland Gmbh | Miniaturisierte mikrotiterplatte für hochdurchsatz-screening |
| GB0012362D0 (en) * | 2000-05-22 | 2000-07-12 | Aventis Pharma Ltd | Chemical compounds |
| CN1488000A (zh) | 2001-02-23 | 2004-04-07 | 比奥维特罗姆股份公司 | 纯化可溶性ssao的方法 |
-
2008
- 2008-01-08 MY MYPI20092874 patent/MY152893A/en unknown
- 2008-01-08 KR KR1020097016630A patent/KR20090107533A/ko not_active Application Discontinuation
- 2008-01-08 CN CN2008800019890A patent/CN101578375B/zh not_active Expired - Fee Related
- 2008-01-08 RU RU2009130380/10A patent/RU2009130380A/ru unknown
- 2008-01-08 EP EP08705761A patent/EP2121964A1/en not_active Withdrawn
- 2008-01-08 US US12/518,318 patent/US20100028895A1/en not_active Abandoned
- 2008-01-08 CA CA002674704A patent/CA2674704A1/en not_active Abandoned
- 2008-01-08 BR BRPI0806321-4A patent/BRPI0806321A2/pt not_active IP Right Cessation
- 2008-01-08 JP JP2009545630A patent/JP2010515461A/ja active Pending
- 2008-01-08 AU AU2008204923A patent/AU2008204923A1/en not_active Abandoned
- 2008-01-08 MX MX2009005962A patent/MX2009005962A/es active IP Right Grant
- 2008-01-08 WO PCT/US2008/050456 patent/WO2008086325A1/en active Application Filing
- 2008-01-08 AR ARP080100060A patent/AR064776A1/es not_active Application Discontinuation
- 2008-01-08 SG SG2011095783A patent/SG177920A1/en unknown
- 2008-01-08 UA UAA200908386A patent/UA103300C2/ru unknown
- 2008-01-08 NZ NZ578079A patent/NZ578079A/xx not_active IP Right Cessation
- 2008-01-10 TW TW097100934A patent/TW200907065A/zh unknown
-
2009
- 2009-06-04 ZA ZA200903897A patent/ZA200903897B/xx unknown
- 2009-06-08 TN TNP2009000232A patent/TN2009000232A1/fr unknown
- 2009-06-11 CR CR10862A patent/CR10862A/es not_active Application Discontinuation
- 2009-07-02 NI NI200900132A patent/NI200900132A/es unknown
- 2009-07-05 IL IL199707A patent/IL199707A0/en unknown
- 2009-07-08 SV SV2009003327A patent/SV2009003327A/es unknown
- 2009-07-09 GT GT200900199A patent/GT200900199A/es unknown
- 2009-07-09 DO DO2009000175A patent/DOP2009000175A/es unknown
- 2009-07-09 EC EC2009009507A patent/ECSP099507A/es unknown
- 2009-07-09 HN HN2009001289A patent/HN2009001289A/es unknown
- 2009-08-06 MA MA32157A patent/MA31226B1/fr unknown
- 2009-08-10 NO NO20092816A patent/NO20092816L/no not_active Application Discontinuation
-
2010
- 2010-04-20 HK HK10103802.0A patent/HK1137784A1/xx not_active IP Right Cessation
-
2012
- 2012-11-18 US US13/680,068 patent/US8883410B2/en not_active Expired - Fee Related
-
2014
- 2014-05-12 US US14/275,359 patent/US20140363836A1/en not_active Abandoned
- 2014-06-04 JP JP2014115352A patent/JP2014204727A/ja not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |