AR061418A1 - Formas cristalinas del compuesto clorhidrato de [r]-5-(2-aminometil)-1-(6,8-difluorocroman-3-il)-1,3-dihidroimidazol-2-tiona y metodos para su preparacion - Google Patents

Formas cristalinas del compuesto clorhidrato de [r]-5-(2-aminometil)-1-(6,8-difluorocroman-3-il)-1,3-dihidroimidazol-2-tiona y metodos para su preparacion

Info

Publication number
AR061418A1
AR061418A1 ARP070102331A ARP070102331A AR061418A1 AR 061418 A1 AR061418 A1 AR 061418A1 AR P070102331 A ARP070102331 A AR P070102331A AR P070102331 A ARP070102331 A AR P070102331A AR 061418 A1 AR061418 A1 AR 061418A1
Authority
AR
Argentina
Prior art keywords
difluorocroman
aminometil
tiona
dihydroimidazol
chlorhydrate
Prior art date
Application number
ARP070102331A
Other languages
English (en)
Original Assignee
Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portela & Ca Sa filed Critical Portela & Ca Sa
Publication of AR061418A1 publication Critical patent/AR061418A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: La forma cristalina A de clorhidrato de (R)-5-(2-aminoetil)-1-(6,8-difluorocroman-3-il)-1,3-didhidroimidazol-2-tiona que tiene un patron XRPD con picos de 8,3 y 26,8 +/- 0,2 °2theta. .
ARP070102331A 2006-05-31 2007-05-30 Formas cristalinas del compuesto clorhidrato de [r]-5-(2-aminometil)-1-(6,8-difluorocroman-3-il)-1,3-dihidroimidazol-2-tiona y metodos para su preparacion AR061418A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0610804.7A GB0610804D0 (en) 2006-05-31 2006-05-31 New crystal forms
GBGB0706647.5A GB0706647D0 (en) 2006-05-31 2007-04-04 New crystal forms

Publications (1)

Publication Number Publication Date
AR061418A1 true AR061418A1 (es) 2008-08-27

Family

ID=36694737

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102331A AR061418A1 (es) 2006-05-31 2007-05-30 Formas cristalinas del compuesto clorhidrato de [r]-5-(2-aminometil)-1-(6,8-difluorocroman-3-il)-1,3-dihidroimidazol-2-tiona y metodos para su preparacion

Country Status (16)

Country Link
US (1) US20100113550A1 (es)
EP (1) EP2027118A2 (es)
JP (1) JP2009538904A (es)
KR (1) KR20090014225A (es)
CN (1) CN101484451A (es)
AR (1) AR061418A1 (es)
AU (1) AU2007268380A1 (es)
BR (1) BRPI0711508A2 (es)
CA (1) CA2653956A1 (es)
GB (2) GB0610804D0 (es)
IL (1) IL195529A0 (es)
MX (1) MX2008015044A (es)
NO (1) NO20084909L (es)
RU (1) RU2008151891A (es)
WO (1) WO2007139413A2 (es)
ZA (1) ZA200810190B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2231648A1 (en) * 2007-12-05 2010-09-29 BIAL - Portela & Ca., S.A. New salts and crystal forms
WO2011115069A1 (ja) * 2010-03-19 2011-09-22 第一三共株式会社 結晶の網羅的探索
CA2890920C (en) 2012-11-14 2020-12-15 Bial - Portela & Ca, S.A. 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991106A (en) * 1974-09-13 1976-11-09 Merck & Co., Inc. 16-Ethers of 8-aza-9-dioxothia-11,12-seco-prostaglandins
US4032617A (en) * 1975-12-03 1977-06-28 Olin Corporation Bis(3,5-difluorosalicylaldehyde)ethylenediimine-Co+2 compound and use
USRE32868E (en) * 1980-04-22 1989-02-14 Research Corporation Antihyperlipidemic compositions
US4395417A (en) * 1980-04-22 1983-07-26 Research Corporation Antihyperlipidemic compositions
GB8401288D0 (en) * 1984-01-18 1984-02-22 Pfizer Ltd Therapeutic agents
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
CA2153498A1 (en) * 1993-11-10 1995-05-18 Hidetsura Cho Chroman derivative and medicinal use thereof
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
EP1671962A1 (en) * 2003-10-10 2006-06-21 Ono Pharmaceutical Co., Ltd. Novel fused heterocyclic compound and use thereof
EP1574499A1 (en) * 2004-03-08 2005-09-14 DKFZ Deutsches Krebsforschungszentrum Inhibitors of DNA methylation in tumor cells
US20050245489A1 (en) * 2004-05-03 2005-11-03 Pinney Kevin G Chromene-containing compounds with anti-tubulin and vascular targeting activity
US7456214B2 (en) * 2004-05-03 2008-11-25 Baylor University Chromene-containing compounds with anti-tubulin and vascular targeting activity
US7528267B2 (en) * 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes

Also Published As

Publication number Publication date
JP2009538904A (ja) 2009-11-12
BRPI0711508A2 (pt) 2011-11-01
ZA200810190B (en) 2009-08-26
US20100113550A1 (en) 2010-05-06
MX2008015044A (es) 2008-12-10
NO20084909L (no) 2008-12-23
AU2007268380A1 (en) 2007-12-06
WO2007139413A3 (en) 2008-04-03
GB0610804D0 (en) 2006-07-12
RU2008151891A (ru) 2010-07-10
WO2007139413A2 (en) 2007-12-06
IL195529A0 (en) 2009-09-01
EP2027118A2 (en) 2009-02-25
CN101484451A (zh) 2009-07-15
KR20090014225A (ko) 2009-02-06
CA2653956A1 (en) 2007-12-06
GB0706647D0 (en) 2007-05-16

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