AR051448A1 - DERIVATIVES OF BENCIMIDAZOL AS SELECTIVE AGONISTS OF THE CB1 RECEPTORS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PAIN AND OTHER DISEASES. - Google Patents

DERIVATIVES OF BENCIMIDAZOL AS SELECTIVE AGONISTS OF THE CB1 RECEPTORS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PAIN AND OTHER DISEASES.

Info

Publication number
AR051448A1
AR051448A1 ARP050104023A ARP050104023A AR051448A1 AR 051448 A1 AR051448 A1 AR 051448A1 AR P050104023 A ARP050104023 A AR P050104023A AR P050104023 A ARP050104023 A AR P050104023A AR 051448 A1 AR051448 A1 AR 051448A1
Authority
AR
Argentina
Prior art keywords
preparation
compound
pain
diseases
methyl
Prior art date
Application number
ARP050104023A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2004/004126 external-priority patent/WO2005030733A1/en
Priority claimed from PCT/GB2004/004112 external-priority patent/WO2005030761A1/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR051448A1 publication Critical patent/AR051448A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas que comprenden los compuestos. Son utiles en tratamientos, en particular para el tratamiento del dolor y otras enfermedades. Reivindicacion 1: Un compuesto de la formula (1), una sal farmacéuticamente aceptable, diastereomeros, enantiomeros, o mezclas, de dicho compuesto donde R1 se selecciona de alquilo C1-6 y cicloalquilo C3-6; R2 se selecciona de -H y metilo; y R3, R4 y R5 se seleccionan, de manera independiente, de F y metilo. Reivindicacion 13. Un método para preparar un compuesto de la formula (1), que comprende la reaccion de un compuesto de formula (2) con un compuesto de formula (3) donde R1 se selecciona de alquilo C1-6 y cicloalquilo C3-6; R2 se selecciona de -H y metilo; y R3, R4 y R5 se seleccionan, de manera independiente, de F y metilo. Reivindicacion 14: Un método para preparar un compuesto de la formula (1), que comprende la reaccion de un compuesto de formula (4) con R1-C(=O)-X, donde X se selecciona de -Cl, -Br y -I; R1 se selecciona de alquilo C1-6 y cicloalquilo C3-6, opcionalmente sustituidos con amino, ciano, halogeno y heterocicloalquilo C2-5; R2 se selecciona de -H y metilo; y R3, R4 y R5 se seleccionan, de manera independiente, de F y metilo.Pharmaceutical compositions comprising the compounds. They are useful in treatments, in particular for the treatment of pain and other diseases. Claim 1: A compound of the formula (1), a pharmaceutically acceptable salt, diastereomers, enantiomers, or mixtures, of said compound wherein R 1 is selected from C 1-6 alkyl and C 3-6 cycloalkyl; R2 is selected from -H and methyl; and R3, R4 and R5 are independently selected from F and methyl. Claim 13. A method of preparing a compound of the formula (1), comprising the reaction of a compound of formula (2) with a compound of formula (3) wherein R 1 is selected from C 1-6 alkyl and C 3-6 cycloalkyl ; R2 is selected from -H and methyl; and R3, R4 and R5 are independently selected from F and methyl. Claim 14: A method of preparing a compound of the formula (1), comprising the reaction of a compound of formula (4) with R1-C (= O) -X, wherein X is selected from -Cl, -Br and -I; R1 is selected from C1-6 alkyl and C3-6 cycloalkyl, optionally substituted with amino, cyano, halogen and C2-5 heterocycloalkyl; R2 is selected from -H and methyl; and R3, R4 and R5 are independently selected from F and methyl.

ARP050104023A 2004-09-24 2005-09-26 DERIVATIVES OF BENCIMIDAZOL AS SELECTIVE AGONISTS OF THE CB1 RECEPTORS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PAIN AND OTHER DISEASES. AR051448A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2004/004126 WO2005030733A1 (en) 2003-09-26 2004-09-24 Benzimidazole derivatives, compositions containing them, preparation therof and uses thereof
PCT/GB2004/004112 WO2005030761A1 (en) 2003-09-26 2004-09-24 Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0500453 2005-02-28

Publications (1)

Publication Number Publication Date
AR051448A1 true AR051448A1 (en) 2007-01-17

Family

ID=36090308

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104023A AR051448A1 (en) 2004-09-24 2005-09-26 DERIVATIVES OF BENCIMIDAZOL AS SELECTIVE AGONISTS OF THE CB1 RECEPTORS, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF PAIN AND OTHER DISEASES.

Country Status (5)

Country Link
EP (1) EP1797075A1 (en)
JP (1) JP2008514591A (en)
AR (1) AR051448A1 (en)
UY (1) UY29133A1 (en)
WO (1) WO2006033629A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302573D0 (en) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
RU2374234C2 (en) 2004-09-24 2009-11-27 Астразенека Аб Benzimidazole derivatives, compositions containing said derivatives, production and use thereof
TW200745049A (en) 2006-03-23 2007-12-16 Astrazeneca Ab New crystalline forms
TW200808769A (en) 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101387D0 (en) * 2001-04-20 2001-04-20 Astrazeneca Ab Novel compounds
SE0301701D0 (en) * 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302571D0 (en) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302570D0 (en) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Also Published As

Publication number Publication date
JP2008514591A (en) 2008-05-08
EP1797075A1 (en) 2007-06-20
WO2006033629A1 (en) 2006-03-30
UY29133A1 (en) 2006-04-28

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