AR047818A1 - Derivados de piperidinilalquilcarbamatos, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de piperidinilalquilcarbamatos, su preparacion y su aplicacion en terapeutica

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Publication number
AR047818A1
AR047818A1 ARP050100668A ARP050100668A AR047818A1 AR 047818 A1 AR047818 A1 AR 047818A1 AR P050100668 A ARP050100668 A AR P050100668A AR P050100668 A ARP050100668 A AR P050100668A AR 047818 A1 AR047818 A1 AR 047818A1
Authority
AR
Argentina
Prior art keywords
group
naphthinyl
cycloalkyl
alkyl
pyrimidyl
Prior art date
Application number
ARP050100668A
Other languages
English (en)
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Jean Jeunesse
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR047818A1 publication Critical patent/AR047818A1/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Composicion farmacéutica que los comprende y usos. Reivindicacion 1: Compuestos que responden a la formula (1), en donde: m representa un numero entero de 1 a 4; n representa un numero entero igual a 1, 2 o 3; o un numero entero igual a 1 o 2; A es seleccionado entre uno o más grupos X, Y y/o Z; X representa un grupo metileno eventualmente sustituido por uno o dos grupos alquilo-C1-6, cicloalquilo-C3-7 o cicloalquilo-C3-7-alquileno-C1-3; Y representa o bien un grupo alquinileno-C2 eventualmente sustituido por uno o dos grupos alquilo-C1-6, cicloalquilo-C3-7 o cicloalquilo-C3-7-alquileno-C1-3; o bien un grupo; Z representa un grupo de formulas (2), p representa un numero entero de 1 a 5, q y r representan numeros enteros y son definidos de tal modo que r + q sea un numero de 1 a 5; B representa un enlace covalente o un grupo alquileno-C1-6; G representa un enlace covalente, un átomo de oxígeno o de azufre o un grupo -CH(OH)-, CO, SO o SO2; R1 representa un grupo R4 eventualmente sustituido por uno o más grupos R5 y/o R6; R4 representa un grupo seleccionado entre un furanilo, pirrolilo, tienilo, isoxazolilo, tiazolilo, isotiazolilo, imidazolilo, pirazolilo, tiadiazolilo, isotiadiazolilo, oxadiazolilo, tiadiazolilo, triazolilo, tetrazolilo, fenilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo, triazinilo, naftalenilo, quinolinilo, tetrahidroquinolinilo, isoquinolinilo, tetrahidroisoquinolinilo, ftalazinilo, quinazolinilo, quinoxalinilo, cinnolinilo, naftiridinilo, imidazopirimidinilo, tienopirimidinilo, benzofuranilo, dihidrobenzofuranilo, benzotienilo, dihidrobenzotienilo, benzimidazolilo, benzoxazolilo, benzisoxazolilo, benzotiazolilo, benzisotiazolilo, indolilo, isoindolilo, indazolilo, pirrolopiridinilo, furopiridinilo, dihidrofuropiridinilo, tienopiridinilo, dihidrotienopiridinilo, imidazopiridinilo, pirazolopiridinilo, oxazolopiridinilo, isoxazolopiridinilo, tiazolopiridinilo; R5 representa un átomo de halogeno, un grupo ciano, nitro, hidroxilo, alquilo-C1-6, alcoxi-C1-6, tioalquilo-C1-6, fluoroalquilo-C1-6, fluoroalcoxi-C1-6, fluorotioalquilo-C1-6, cicloalquilo-C3-7, cicloalquilo-C3-7-alquileno-C1-3, NR7R8, NR7COR8, NR7CO2R8, NR7SO2R8, COR7, CO2R7, CONR7R8, SO2R7, SO2NR7R8, u -O-(alquileno-C1-3)-O; R6 representa un grupo fenilo, feniloxi, benziloxi, piridinilo, pirazinilo, piridazinilo, pirimidinilo o pirimidiniloxi; pudiendo el o los grupos R6 estar sustituidos por uno o más grupos R5 idénticos o diferentes uno del otro; R7 y R8 representan independientemente uno del otro un átomo de hidrogeno o un grupo alquilo-C1-6, o forman con el o los átomos que los llevan un ciclo seleccionado entre un ciclo azetidina, pirrolidina, piperidina, morfolina, tiomorfolina, azepina o piperazina, estando este ciclo eventualmente sustituido por un grupo alquilo-C1-6 o benzilo; R2 representa un átomo de hidrogeno o un grupo alquilo-C1-6; R3 representa un átomo de hidrogeno o un grupo alquilo-C1-6, cicloalquilo-C3-7, cicloalquiklo-C3-7-alquileno-C1-3; en el estado de base, de sal de adicion de un ácido, de hidrato o de solvato.
ARP050100668A 2004-02-26 2005-02-24 Derivados de piperidinilalquilcarbamatos, su preparacion y su aplicacion en terapeutica AR047818A1 (es)

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FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
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EP2081905B1 (en) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor
CN101516839A (zh) 2006-09-25 2009-08-26 贝林格尔.英格海姆国际有限公司 调节cb2受体的化合物
JP5492092B2 (ja) 2007-11-07 2014-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
JP5749162B2 (ja) 2008-07-10 2015-07-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するスルホン化合物
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CA2554608A1 (fr) 2005-09-29
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