AR045928A1 - AMIDAS N-SUBSTITUTED INDOLIL-3-GLIOXYL ACID, ITS USE AS MEDICATIONS AND PROCEDURE FOR PREPARATION - Google Patents
AMIDAS N-SUBSTITUTED INDOLIL-3-GLIOXYL ACID, ITS USE AS MEDICATIONS AND PROCEDURE FOR PREPARATIONInfo
- Publication number
- AR045928A1 AR045928A1 ARP040102632A ARP040102632A AR045928A1 AR 045928 A1 AR045928 A1 AR 045928A1 AR P040102632 A ARP040102632 A AR P040102632A AR P040102632 A ARP040102632 A AR P040102632A AR 045928 A1 AR045928 A1 AR 045928A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- substituted
- alkyl
- cycloalkyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Amidas N-sustituidas de ácido indolil-3-glioxílico conformes a la fórmula general (1), a su preparación y uso como medicamento, en particular para el tratamiento de tumores. Reivindicación 1: Amidas N-sustituidas de ácido indolil-3-glioxílico caracterizadas porque tienen la fórmula general (1) en la que R1, R3-R6 significan: H, alquilo no sustituido o sustituido; cicloalquilo no sustituido o sustituido; arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, alquilheteroarilo no sustituido o sustituido, amino, mono-alquilamino, di-alquilamino, halógeno, alquilo sustituido por uno o más átomos de F, preferiblemente el grupo trifluorometilo, ciano, ciano-alquilo de cadena recta o ramificado, alquilcarbonilo, carboxilo, alcoxicarbonilo, carboxi-alquilo o alcoxicarbonil-alquilo, alcoxi, aril-alcoxi, preferiblemente benciloxi, alcoxicarbonilamino, alcoxicarbonilamino-alquilo; R2 significa: alquilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, alquilheteroarilo no sustituido o sustituido, R7 significa: una sulfona de la fórmula -SO2-X1, en la que X1 significa N(Alqu)2, hidroxilo, alquilo no sustituido o sustituido, cicloalquilo no sustituido o sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquil-cicloalquilo no sustituido o sustituido, alquil-heterociclilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, alquilheteroarilo no sustituido o sustituido; -C(O)-X2, en la que X2 significa arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, y alquilheteroarilo no sustituido o sustituido; -C(O)O-X3-, en la que X3 significa cicloalquilo no sustituido o sustituido, heterociclilo no sustituido o sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquil-cicloalquilo no sustituido o sustituido, alquil-heterociclilo no sustituido o sustituido, y alquilheteroarilo no sustituido o sustituido; -C(O)NX4X5, en la que X4 y X5 significan, independientemente el uno del otro, H, alquilo no sustituido o sustituido, cicloalquilo no sustituido o sustituido, heterociclilo no sustituido o sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquil-cicloalquilo no sustituido o sustituido, alquil-heterociclilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, alquilheteroarilo no sustituido o sustituido, o bien X4 y X5 significan conjuntamente cicloalquilo o cicloheteroalquilo, -C(S)NX6X7,en la que X6 y X7 significan, independientemente el uno del otro, H, alquilo no sustituido o sustituido, cicloalquilo no sustituido o sustituido, heterociclilo no sustituido o sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquil-cicloalquilo no sustituido o sustituido, alquil-heterociclilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, alquilheteroarilo no sustituido o sustituido, o bien X6 y X7 significan conjuntamente cicloalquilo o cicloheteroalquilo, X significa: O, S o H e hidroxilo enlazados en forma geminada; Y significa O o S, y HET: representa un heterociclo-(C2-14) saturado, insaturado o aromático, que contiene uno o varios heteroátomos seleccionados entre el grupo de N, O y S, unido con el N de la amida directamente o a través de un puente de alquilo (C1-6), y el resto alquilo puede estar sustituido o no sustituido, y en el que al heterociclo pueden estar unidos opcionalmente por condensación uno o dos grupos arilo o cicloalquilo, pudiendo estar el resto alquilo en todos los casos ramificado o no ramificado y saturado o no saturado y los grupos heterocíclicos, arilo o cicloalquilo pueden estar no sustituido o sustituidos, así como las sales farmacéuticamente compatibles de éstos.N-substituted indolyl-3-glyoxylic acid amides conforming to the general formula (1), its preparation and use as a medicament, in particular for the treatment of tumors. Claim 1: N-substituted indolyl-3-glyoxylic acid amides characterized in that they have the general formula (1) in which R1, R3-R6 means: H, unsubstituted or substituted alkyl; unsubstituted or substituted cycloalkyl; unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted alkylaryl, unsubstituted or substituted alkylheteroaryl, amino, mono-alkylamino, di-alkylamino, halogen, alkyl substituted by one or more F atoms, preferably the trifluoromethyl group , cyano, straight or branched chain cyanoalkyl, alkylcarbonyl, carboxyl, alkoxycarbonyl, carboxy-alkyl or alkoxycarbonyl-alkyl, alkoxy, aryl-alkoxy, preferably benzyloxy, alkoxycarbonylamino, alkoxycarbonylamino-alkyl; R2 means: unsubstituted or substituted alkyl, unsubstituted or substituted alkylaryl, unsubstituted or substituted alkylheteroaryl, R7 means: a sulfone of the formula -SO2-X1, wherein X1 means N (Alkyl) 2, hydroxyl, unsubstituted alkyl or substituted, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted alkyl-cycloalkyl, unsubstituted or substituted alkyl-heterocyclyl, unsubstituted or substituted alkylaryl, unsubstituted or substituted alkylheteroaryl; -C (O) -X2, wherein X2 means unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted alkylaryl, and unsubstituted or substituted alkylheteroaryl; -C (O) O-X3-, in which X3 means unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted alkyl-cycloalkyl, alkyl heterocyclyl unsubstituted or substituted, and unsubstituted or substituted alkylheteroaryl; -C (O) NX4X5, wherein X4 and X5 mean, independently of each other, H, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted heteroaryl or substituted, unsubstituted or substituted alkyl-cycloalkyl, unsubstituted or substituted alkyl-heterocyclyl, unsubstituted or substituted alkylaryl, unsubstituted or substituted alkylheteroaryl, or else X4 and X5 together mean cycloalkyl or cycloheteroalkyl, -C (S) NX6X7, in which X6 and X7 mean, independently of each other, H, unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted alkylcycloalkyl or substituted, unsubstituted or substituted alkyl heterocyclyl, unsubstituted or substituted alkylaryl, unsubstituted or substituted alkylheteroaryl, or X6 and X7 together means cycloalkyl or cycloheteroalkyl, X means: O, S or H and hydroxy linked in geminated form; Y means O or S, and HET: represents a saturated, unsaturated or aromatic heterocycle- (C2-14), which contains one or more heteroatoms selected from the group of N, O and S, joined with the N of the amide directly or through a (C1-6) alkyl bridge, and the alkyl moiety may be substituted or unsubstituted, and in which one or two aryl or cycloalkyl groups may be optionally linked to the heterocycle, the alkyl moiety may be in all branched or unbranched and saturated or unsaturated cases and heterocyclic, aryl or cycloalkyl groups may be unsubstituted or substituted, as well as pharmaceutically compatible salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10334040A DE10334040A1 (en) | 2003-07-25 | 2003-07-25 | Novel N-substituted indolyl-3-glyoxylic acid amides, their use as medicaments and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045928A1 true AR045928A1 (en) | 2005-11-16 |
Family
ID=34129467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102632A AR045928A1 (en) | 2003-07-25 | 2004-07-23 | AMIDAS N-SUBSTITUTED INDOLIL-3-GLIOXYL ACID, ITS USE AS MEDICATIONS AND PROCEDURE FOR PREPARATION |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1651600A2 (en) |
| JP (1) | JP2007503376A (en) |
| KR (1) | KR20060037398A (en) |
| CN (1) | CN1839129A (en) |
| AR (1) | AR045928A1 (en) |
| AU (1) | AU2004263238A1 (en) |
| BR (1) | BRPI0412898A (en) |
| CA (1) | CA2533433A1 (en) |
| DE (1) | DE10334040A1 (en) |
| IL (1) | IL173335A0 (en) |
| MX (1) | MXPA06000995A (en) |
| NO (1) | NO20060697L (en) |
| RS (1) | RS20060049A (en) |
| RU (1) | RU2317293C9 (en) |
| TW (1) | TW200524863A (en) |
| UA (1) | UA83498C2 (en) |
| WO (1) | WO2005014542A2 (en) |
| ZA (1) | ZA200601300B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5406716B2 (en) | 2006-08-07 | 2014-02-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Indole compounds |
| AR084433A1 (en) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | FAAH INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005504790A (en) * | 2001-09-13 | 2005-02-17 | シンタ ファーマスーティカルズ コーポレイション | 3-glyoxylylamidoindole for treating cancer |
-
2003
- 2003-07-25 DE DE10334040A patent/DE10334040A1/en not_active Withdrawn
-
2004
- 2004-07-09 RS YUP-2006/0049A patent/RS20060049A/en unknown
- 2004-07-09 BR BRPI0412898-2A patent/BRPI0412898A/en not_active IP Right Cessation
- 2004-07-09 KR KR1020067001636A patent/KR20060037398A/en not_active Application Discontinuation
- 2004-07-09 WO PCT/EP2004/007573 patent/WO2005014542A2/en active Application Filing
- 2004-07-09 EP EP04740854A patent/EP1651600A2/en not_active Withdrawn
- 2004-07-09 RU RU2006105708/04A patent/RU2317293C9/en not_active IP Right Cessation
- 2004-07-09 CA CA002533433A patent/CA2533433A1/en not_active Abandoned
- 2004-07-09 CN CNA2004800240832A patent/CN1839129A/en active Pending
- 2004-07-09 JP JP2006521430A patent/JP2007503376A/en not_active Withdrawn
- 2004-07-09 AU AU2004263238A patent/AU2004263238A1/en not_active Abandoned
- 2004-07-09 MX MXPA06000995A patent/MXPA06000995A/en unknown
- 2004-07-19 TW TW093121509A patent/TW200524863A/en unknown
- 2004-07-23 AR ARP040102632A patent/AR045928A1/en not_active Application Discontinuation
- 2004-09-07 UA UAA200601216A patent/UA83498C2/en unknown
-
2006
- 2006-01-24 IL IL173335A patent/IL173335A0/en unknown
- 2006-02-13 ZA ZA200601300A patent/ZA200601300B/en unknown
- 2006-02-14 NO NO20060697A patent/NO20060697L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005014542A2 (en) | 2005-02-17 |
| TW200524863A (en) | 2005-08-01 |
| RU2317293C2 (en) | 2008-02-20 |
| RS20060049A (en) | 2008-08-07 |
| DE10334040A1 (en) | 2005-03-10 |
| ZA200601300B (en) | 2007-03-28 |
| EP1651600A2 (en) | 2006-05-03 |
| AU2004263238A1 (en) | 2005-02-17 |
| RU2006105708A (en) | 2006-06-27 |
| NO20060697L (en) | 2006-02-14 |
| KR20060037398A (en) | 2006-05-03 |
| RU2317293C9 (en) | 2008-05-10 |
| BRPI0412898A (en) | 2006-10-03 |
| CN1839129A (en) | 2006-09-27 |
| WO2005014542A3 (en) | 2006-10-19 |
| IL173335A0 (en) | 2006-06-11 |
| CA2533433A1 (en) | 2005-02-17 |
| MXPA06000995A (en) | 2006-04-11 |
| JP2007503376A (en) | 2007-02-22 |
| UA83498C2 (en) | 2008-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |