AR041764A1 - Vacuna basada en polinucleotidos y proteinas derivados del vih - Google Patents
Vacuna basada en polinucleotidos y proteinas derivados del vihInfo
- Publication number
- AR041764A1 AR041764A1 ARP030104033A ARP030104033A AR041764A1 AR 041764 A1 AR041764 A1 AR 041764A1 AR P030104033 A ARP030104033 A AR P030104033A AR P030104033 A ARP030104033 A AR P030104033A AR 041764 A1 AR041764 A1 AR 041764A1
- Authority
- AR
- Argentina
- Prior art keywords
- hiv
- protein
- pharmaceutical composition
- additional
- composition according
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 230000002163 immunogen Effects 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 101710091045 Envelope protein Proteins 0.000 abstract 2
- 101710188315 Protein X Proteins 0.000 abstract 2
- 102100021696 Syncytin-1 Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 238000011238 DNA vaccination Methods 0.000 abstract 1
- 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 1
- 239000010931 gold Substances 0.000 abstract 1
- 229910052737 gold Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se refiere a polinucleótidos para la vacunación con ADN, polinucleótidos que codifican una proteína de la cubierta del VIH o fragmento o derivado inmunógeno, que no está glicosilada cuando se expresa en una célula diana de mamífero, ligada de forma operable a un promotor heterólogo. Preferiblemente la molécula de la cubierta del VIH, tal como gp120 o gp140 o gp160, carece de una senal de secreción funcional. Puede estar fusionada a proteínas adicionales del VIH tales como Nef, Gag, RT o Tat. Reivindicación 25: Una proteína de fusión que comprende una proteína de la cubierta del VIH sustancialmente no glicosilada o un fragmento o derivado inmunógeno de la misma y al menos una proteína adicional del VIH o un fragmento derivado inmunógeno de la misma, seleccionándose dicha proteína adicional del VIH de Nef, Gag, RT y Tat. Reivindicación 28: Una composición farmacéutica que comprende una secuencia nucleótida o un conjunto de secuencias nucleotídicas de acuerdo con una cualquiera de las reivindicaciones 1 a 20, un vector de las reivindicaciones 21 a 24, una proteína de fusión de acuerdo con la reivindicación 25 o una composición de acuerdo con la reivindicación 26 o un polipéptido de acuerdo con la reivindicación 27, y un excipiente, diluyente, vehículo o adyuvante farmacéuticamente aceptable. Reivindicación 29: La composición farmacéutica de acuerdo con la reivindicación 28 en la que el vehículo es una pluralidad de partículas tales como perlas de oro. Reivindicación 31: Un dispositivo de administración intradérmica que comprende una composición farmacéutica de acuerdo con una cualquiera de las reivindicaciones 28 a 30.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0225788.9A GB0225788D0 (en) | 2002-11-05 | 2002-11-05 | Vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041764A1 true AR041764A1 (es) | 2005-05-26 |
Family
ID=9947247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104033A AR041764A1 (es) | 2002-11-05 | 2003-11-04 | Vacuna basada en polinucleotidos y proteinas derivados del vih |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7655235B2 (es) |
| EP (1) | EP1558636A2 (es) |
| JP (1) | JP2006520185A (es) |
| AR (1) | AR041764A1 (es) |
| AU (1) | AU2003301850A1 (es) |
| CA (1) | CA2505209A1 (es) |
| GB (1) | GB0225788D0 (es) |
| TW (1) | TW200418873A (es) |
| WO (1) | WO2004041852A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0225788D0 (en) | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
| SG182173A1 (en) * | 2005-05-12 | 2012-07-30 | Glaxo Group Ltd | Vaccine composition |
| WO2007071997A2 (en) * | 2005-12-21 | 2007-06-28 | Glaxo Group Limited | Method of eliciting immune response |
| TWI477602B (zh) * | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
| US9333249B2 (en) | 2006-02-09 | 2016-05-10 | Educational Foundation Jichi Medical University | Recombinant baculovirus vaccine |
| US7628993B2 (en) | 2006-07-20 | 2009-12-08 | Vical Incorporated | Compositions and methods for vaccinating against HSV-2 |
| CN101675068A (zh) * | 2007-03-02 | 2010-03-17 | 葛兰素史密丝克莱恩生物有限公司 | 新的方法和组合物 |
| CN102625842A (zh) * | 2009-03-13 | 2012-08-01 | 艾根股份有限公司 | 用于输送生物活性rna的组合物和方法 |
| EP2603224A1 (en) | 2010-08-09 | 2013-06-19 | Cyvax, Inc. | Methods and compositions for preventing a condition |
| US8932575B2 (en) | 2010-09-21 | 2015-01-13 | University Of Miami | Compositions and methods for inducing migration by dendritic cells and an immune response |
| WO2012040266A2 (en) * | 2010-09-24 | 2012-03-29 | University Of Miami | Gene-based adjuvants and compositions thereof to increase antibody production in response to gene-based vaccines |
| MA40783A (fr) * | 2014-10-03 | 2017-08-08 | Los Alamos Nat Security Llc | Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population |
| AU2020315598A1 (en) | 2019-07-16 | 2022-03-03 | Gilead Sciences, Inc. | HIV vaccines and methods of making and using |
| US12053517B2 (en) | 2021-01-14 | 2024-08-06 | Gilead Sciences, Inc. | HIV vaccines and methods of using |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0172970B1 (ko) | 1992-06-17 | 1999-02-01 | 김영길 | Aids백신에 유용한 키메릭 단백 및 그의 제조방법 |
| WO1995032000A1 (en) * | 1994-05-20 | 1995-11-30 | Microgenesys, Inc. | Hiv polyprotein immunogens |
| AU6535898A (en) | 1997-03-14 | 1998-10-12 | President And Fellows Of Harvard College | Glycosylation deficient siv and hiv envelope glycoproteins |
| GB9720585D0 (en) | 1997-09-26 | 1997-11-26 | Smithkline Beecham Biolog | Vaccine |
| AU1023401A (en) | 1999-10-12 | 2001-04-23 | Institut Pasteur | Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice |
| US6656706B2 (en) | 1999-12-23 | 2003-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
| CN1213068C (zh) | 1999-12-23 | 2005-08-03 | 医疗研究局 | 对hiv免疫应答的改进或与其相关的改进 |
| AP2002002592A0 (en) * | 2000-01-31 | 2002-09-30 | Smithkline Beecham Biolog | Vaccine for the prophylactic or therapeutic immunization against HIV. |
| IL150961A0 (en) * | 2000-02-04 | 2003-02-12 | Univ Duke | Human immunodeficiency virus vaccine |
| GB0027088D0 (en) * | 2000-11-06 | 2000-12-20 | Glaxo Group Ltd | DNA expression vectors |
| WO2002032943A2 (en) * | 2000-08-14 | 2002-04-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
| WO2002020080A2 (en) | 2000-09-06 | 2002-03-14 | Mathis Stephen M | Music assisted therapy |
| CU23235A1 (es) | 2001-02-28 | 2007-09-26 | Ct Ingenieria Genetica Biotech | POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA |
| GB0110431D0 (en) * | 2001-04-27 | 2001-06-20 | Glaxosmithkline Biolog Sa | Novel compounds |
| JP4601956B2 (ja) | 2001-09-20 | 2010-12-22 | グラクソ グループ リミテッド | Ｈｉｖ−ｇａｇのコドン最適化ｄｎａワクチン |
| US20030190308A1 (en) | 2002-03-19 | 2003-10-09 | Braun Ralph P. | Adjuvant |
| GB0225788D0 (en) | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| GB0225786D0 (en) | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
-
2002
- 2002-11-05 GB GBGB0225788.9A patent/GB0225788D0/en not_active Ceased
-
2003
- 2003-11-03 US US10/533,734 patent/US7655235B2/en not_active Expired - Fee Related
- 2003-11-03 TW TW092130709A patent/TW200418873A/zh unknown
- 2003-11-03 JP JP2004549136A patent/JP2006520185A/ja active Pending
- 2003-11-03 CA CA002505209A patent/CA2505209A1/en not_active Abandoned
- 2003-11-03 EP EP03810446A patent/EP1558636A2/en not_active Withdrawn
- 2003-11-03 AU AU2003301850A patent/AU2003301850A1/en not_active Abandoned
- 2003-11-03 WO PCT/EP2003/012402 patent/WO2004041852A2/en active Application Filing
- 2003-11-04 AR ARP030104033A patent/AR041764A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2505209A1 (en) | 2004-05-21 |
| WO2004041852A2 (en) | 2004-05-21 |
| AU2003301850A8 (en) | 2004-06-07 |
| GB0225788D0 (en) | 2002-12-11 |
| US7655235B2 (en) | 2010-02-02 |
| TW200418873A (en) | 2004-10-01 |
| AU2003301850A1 (en) | 2004-06-07 |
| WO2004041852A3 (en) | 2004-06-24 |
| EP1558636A2 (en) | 2005-08-03 |
| JP2006520185A (ja) | 2006-09-07 |
| US20070042977A1 (en) | 2007-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |