AR041131A1 - Derivados de aminoindazol utilizados como medicamentos y composiciones farmaceuticas que los contienen - Google Patents

Derivados de aminoindazol utilizados como medicamentos y composiciones farmaceuticas que los contienen

Info

Publication number
AR041131A1
AR041131A1 ARP030103186A ARP030103186A AR041131A1 AR 041131 A1 AR041131 A1 AR 041131A1 AR P030103186 A ARP030103186 A AR P030103186A AR P030103186 A ARP030103186 A AR P030103186A AR 041131 A1 AR041131 A1 AR 041131A1
Authority
AR
Argentina
Prior art keywords
alkyl
heteroaryl
aryl
nhc
nr10r11
Prior art date
Application number
ARP030103186A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR041131A1 publication Critical patent/AR041131A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: Los compuestos de la fórmula (1), en la cual: R3 es un radical alquilo (C1-6), arilo, aril-alquilo (C1-6), heteroarilo, heteroaril-alquilo (C1-6), arilo o heteroarilo condensado con un cicloalquilo(C1-10), heterociclo, heterocicloalquilo, cicloalquilo, adamantilo, policicloalquilos, alquenilo, alquinilo, CONR1R2, CSNR1R2, CSNR1R2, COOR1, SO2R1, C(=NH)R1, C(=NH)NR1; estando estos radicales eventualmente sustituidos con 1 a varios sustituyentes elegidos entre halógeno, CN, NO2, NH2, OH, OR1, COOH, C(O)OR1, -O-C(O)R1, NR1R2, NH(O)R1, C(O)NR1R2, SR1, S(O)R1, SO2R1, NHSO2R1, SO2NR1R2, C(S)NR1R2, NHC(S)R1, -O-SO2-R1, -SO2-O-R1, arilo, heteroarilo, heterociclo, formilo, trifluorometilo, trifluorometilsulfanilo, trifluorometoxi, alquilo (C1-6); R5, R6 se eligen independientemente uno de otro entre los radicales siguientes, halógeno, CN, NO2, NH2, OH, COOH, C(O)OR8, -O-C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2R8R9, -O-SO2R8, -SO2-O-R8, trifluorometilo, trifluorometoxi, alquilo (C1-6), alcoxi (C1-6), arilo, aril-alquilo (C1-6), heteroarilo, heteroaril-alquilo (C1-6), heterociclo, cicloalquilo, alquenilo, alquinilo, adamantilo, policicloalquilos; estando estos radicales eventualmente sustituidos con 1 o varios sustituyentes elegidos entre halógeno, CN, NO2, NH2, OH, OR10, COOH, C(O)OR10, -O-C(O)R10, NR10R11, NHC(O)R10, C(O)NR10R11, NHC(S)R10, C(S)NR10R11, SR10, S(O)R10, SO2R10, NHSO2R10, SO2NR10R11, -O-SO2R10, -SO2-O-R10, arilo, heteroarilo, formilo, trifluorometilo, trifluorometoxi, alquilo (C1-6); R1, R2, R8, R9, R10, R11 son independientemente uno de otro, un hidrógeno, alquilo (C1-6), arilo, alquenilo, alquinilo, heteroarilo, estando ellos mismos eventualmente sustituidos con 1 o varios sustituyentes elegidos entre halógeno, alquilo (C1-6), alcoxi (C1-6), CN, NO2, NH2, OH, COOH, COOalquilo, CONH2, formilo, trifluorometilo, trifluorometoxi; R1 y R2 o R8 y R9 o R10 y R11 pueden formar un ciclo de 5 ó 6 miembros que tiene o no un heteroátomo tal como O, S, N; y cuando R3 es un heteroarilo nitrogenado de 6 miembros o un tiazolilo o un imidazolilo o un oxazolilo, entonces al menos uno de los R5, R6, es un anillo que está eventualmente sustituido con 1 o varios sustituyentes elegidos entre halógeno, CN, NO2, NH2, OH, OR10, COOH, C(O)OR10, -O-C(O)R10, NR10R11, NHC(O)R10, C(O)NR10R11, NHC(S)R10, C(S)NR10R11, SR10, S(O)R10, SO2R10, NHSO2R10, SO2NR10R11, -O-SO2R10, -SO2-O-R10, arilo, heteroarilo, formilo trifluorometilo, trifluorometoxi, alquilo (C1-6); sus racémicos, enantiómeros, diastereoisómeros y sus mezclas, sus tautómeros y sus sales farmacéuticamente aceptables.
ARP030103186A 2002-09-05 2003-09-03 Derivados de aminoindazol utilizados como medicamentos y composiciones farmaceuticas que los contienen AR041131A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0210962A FR2844267B1 (fr) 2002-09-05 2002-09-05 Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
AR041131A1 true AR041131A1 (es) 2005-05-04

Family

ID=31725841

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103186A AR041131A1 (es) 2002-09-05 2003-09-03 Derivados de aminoindazol utilizados como medicamentos y composiciones farmaceuticas que los contienen

Country Status (9)

Country Link
CN (1) CN1982316A (es)
AR (1) AR041131A1 (es)
FR (1) FR2844267B1 (es)
ME (1) MEP25708A (es)
MY (1) MY146796A (es)
PE (1) PE20040995A1 (es)
RS (1) RS52767B (es)
TW (2) TWI353245B (es)
ZA (1) ZA200501427B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007002717A1 (de) 2007-01-18 2008-07-24 Merck Patent Gmbh Heterocyclische Indazolderivate
DE102007022565A1 (de) 2007-05-14 2008-11-20 Merck Patent Gmbh Heterocyclische Indazolderivate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638926B2 (en) * 2000-09-15 2003-10-28 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
CN100436452C (zh) * 2000-12-21 2008-11-26 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡唑化合物

Also Published As

Publication number Publication date
TWI353978B (en) 2011-12-11
ZA200501427B (en) 2006-04-26
TW200820967A (en) 2008-05-16
CN1982316A (zh) 2007-06-20
RS52767B (sr) 2013-10-31
TWI353245B (en) 2011-12-01
PE20040995A1 (es) 2005-01-28
FR2844267A1 (fr) 2004-03-12
MY146796A (en) 2012-09-28
TW200413325A (en) 2004-08-01
RS20050165A (en) 2007-08-03
FR2844267B1 (fr) 2008-02-15
MEP25708A (en) 2010-06-10

Similar Documents

Publication Publication Date Title
AR038915A1 (es) Derivados de aminoindazoles, procedimiento de preparacion e intermedios de este procedimiento, medicamentos y composiciones farmaceuticas que contienen al compuesto
AR079541A1 (es) Compuestos sustituidos de n-(1h-indazol-4-il) imidazo (1,2-a) piridin-3-carboxamida como inhibidores de cfms
AR025975A1 (es) Compuestos quimicos.
HUP0402376A2 (hu) Imidazol-4-karboxamid-származékok, előállításuk és az ezeket tartalmazó, elhízás kezelésére alkalmas gyógyszerkészítmények
AR058769A1 (es) Inhibidores de peptidil-deformilasa(pdf),utiles para el tratamiento de la tuberculosis y composiciones farmaceuticas que los contienen.
AR039933A1 (es) Indoles sustituidos para tratamiento de desordenes respiratorios
AR049739A1 (es) Derivados de aril-piridina
BR0314098A (pt) Derivados da aminoindazóis a tìtulo de medicamentos e composições farmacêuticas que os contêm
AR045462A1 (es) DERIVADOS DE INDOLES SUSTITUIDOS eTILES COMO COMPUESTOS FARMACEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS
AR064258A1 (es) Inhibidores macrociclicos del virus de hepatitis c
HUP0303652A2 (hu) Ciklikus származékok, mint kemokin receptor aktivitás modulátorai és ezeket tartalmazó gyógyszerkészítmények
CO5280046A1 (es) Agonistas alfa 7 y sus composiciones farmaceuticas
AR039403A1 (es) Derivados de acil-4-carboxifenilurea y su uso como antidiabetico
HUP0301113A2 (hu) Pirrolidinszármazékok, mint ciklusos amp-specifikus foszfodiészteráz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0402529A2 (hu) Xa faktor és más, a koagulációs kaszkádban részt vevő szerin-proteázok inhibitorai, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények
CO5690588A2 (es) Derivados de 4-tetrazolilo-4 fenilpiperidina para el trata- miento del dolor
AR042024A1 (es) Compuestos farmaceuticos derivados de piridona, pirimidona y pirazinona
AR044552A1 (es) Derivados del indol,composiciones farmaceuticas que los contienen y procesos para su preparacion, de utilidad para el tratamiento de trastornos respiratorios
HUP0402454A2 (hu) Szubsztituált kinazolinszármazékok mint az aurora kinázok inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0201988A2 (hu) N-(indolkarbonil)piperazin-származékok
ATE455119T1 (de) Thiazolo-, oxazalo und imidazolo- chinazolinverbindungen, die dazu fähig sind, proteinkinasen zu hemmen
CO5031253A1 (es) Antagonistas receptores y5 de neuropeptidos composiciones farmaceuticas que las contienen
AR039934A1 (es) Indoles sustituidos para el tratamiento de desordenes respiratorios
MXPA03010584A (es) Derivados de tiazol u oxazol que son utiles en el tratamiento de enfermedades cardiovasculares y relacionadas.
CO5601012A2 (es) Compuestos que modulan la actividad de ppar

Legal Events

Date Code Title Description
FB Suspension of granting procedure