AR040259A1 - PROCEDURE WITH HTS CAPACITY AND TEST SYSTEM FOR THE DETERMINATION OF INTERACTION BETWEEN C-REACTIVE PROTEIN AND COMPONENTS UNITED TO C-REACTIVE PROTEIN - Google Patents
PROCEDURE WITH HTS CAPACITY AND TEST SYSTEM FOR THE DETERMINATION OF INTERACTION BETWEEN C-REACTIVE PROTEIN AND COMPONENTS UNITED TO C-REACTIVE PROTEINInfo
- Publication number
- AR040259A1 AR040259A1 ARP030102067A ARP030102067A AR040259A1 AR 040259 A1 AR040259 A1 AR 040259A1 AR P030102067 A ARP030102067 A AR P030102067A AR P030102067 A ARP030102067 A AR P030102067A AR 040259 A1 AR040259 A1 AR 040259A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- crp
- components
- component
- acceptor
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente se refiere a un procedimiento con capacidad HTS y un sistema de ensayo para la determinación de la interacción entre una proteína C-reactiva (CRP) o Clq y componentes unidos a CRP o Clq, para la determinación de la concentración de una solución con contenido en CRP o Clq, así como para la determinación de sustancias que influyen en la interacción de CRP o Clq y componentes unidos a éstos, especialmente la interacción entre CRP y Clq. Reivindicación 1: Procedimiento para la determinación de un suceso de unión de dos componentes unidos a CRP, directamente o a través de uno o más componentes, que comprende las etapas siguientes: (a) disposición de una solución que contiene CRP; (b) adición a la solución que contiene CRP, de al menos un componente donador o un grupo de componentes, que contiene por lo menos un componente donador, tratándose en el caso del componente donador de un componente que comprende por lo menos un compuesto o un grupo de compuestos, que pueden emitir una senal después de la excitación mediante una fuente de luz (grupo donador) y estando el componente donador en condiciones de unirse a CRP, directamente o a través de uno o más componentes del grupo mencionado de componentes; (c) adición a la solución que contiene CRP de al menos un componente aceptor o un grupo de componentes, que contiene por lo menos un componente aceptor, tratándose en el caso del componente aceptor de un componente que comprende por lo menos un compuesto o grupo de compuestos, que captan la senal emitida por el compuesto o grupo de compuestos de acuerdo con (b) y pueden cederla en forma de radiación electromagnética (grupo aceptor) y estando el componente aceptor en condiciones de unirse a CRP, directamente o a través de uno o más componentes del grupo mencionado de componentes; (d) excitación de al menos un compuesto o grupo de compuestos de acuerdo con (b) (grupo donador) mediante una fuente de luz; (e) detección de la radiación electromagnética emitida por al menos un compuesto o grupo de compuestos de acuerdo con (c) (grupo aceptor) para la detección del suceso de unión.This refers to a method with HTS capability and an assay system for the determination of the interaction between a C-reactive protein (CRP) or Clq and components bound to CRP or Clq, for the determination of the concentration of a solution with CRP or Clq content, as well as for the determination of substances that influence the interaction of CRP or Clq and components bound thereto, especially the interaction between CRP and Clq. Claim 1: Method for determining a binding event of two components linked to CRP, directly or through one or more components, comprising the following steps: (a) provision of a solution containing CRP; (b) addition to the solution containing CRP, of at least one donor component or a group of components, which contains at least one donor component, in the case of the donor component of a component comprising at least one compound or a group of compounds, which can emit a signal after excitation by a light source (donor group) and the donor component being able to bind to CRP, directly or through one or more components of the mentioned group of components; (c) addition to the CRP-containing solution of at least one acceptor component or group of components, which contains at least one acceptor component, in the case of the acceptor component of a component comprising at least one compound or group of compounds, which capture the signal emitted by the compound or group of compounds according to (b) and can yield it in the form of electromagnetic radiation (acceptor group) and the acceptor component being able to bind to CRP, directly or through one or more components of the mentioned group of components; (d) excitation of at least one compound or group of compounds according to (b) (donor group) by a light source; (e) detection of the electromagnetic radiation emitted by at least one compound or group of compounds according to (c) (acceptor group) for the detection of the binding event.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10226011A DE10226011A1 (en) | 2002-06-12 | 2002-06-12 | HTS-capable method and test system for determining the interaction between c-reactive protein and components that bind to C-reactive protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040259A1 true AR040259A1 (en) | 2005-03-23 |
Family
ID=29718976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102067A AR040259A1 (en) | 2002-06-12 | 2003-06-10 | PROCEDURE WITH HTS CAPACITY AND TEST SYSTEM FOR THE DETERMINATION OF INTERACTION BETWEEN C-REACTIVE PROTEIN AND COMPONENTS UNITED TO C-REACTIVE PROTEIN |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1516187A2 (en) |
| JP (1) | JP2005529348A (en) |
| CN (1) | CN1745300A (en) |
| AR (1) | AR040259A1 (en) |
| AU (1) | AU2003250344A1 (en) |
| BR (1) | BR0311709A (en) |
| CA (1) | CA2489021A1 (en) |
| DE (1) | DE10226011A1 (en) |
| MX (1) | MXPA04012232A (en) |
| NO (1) | NO20050037L (en) |
| RU (1) | RU2005100042A (en) |
| TW (1) | TW200411179A (en) |
| WO (1) | WO2003107000A2 (en) |
| ZA (1) | ZA200409199B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102721813A (en) * | 2012-07-09 | 2012-10-10 | 沃克(天津)生物科技有限公司 | Homogeneous luminous immunoassay assay kit for prostate specific antigen and detection method therefor |
| CN103852465A (en) * | 2012-11-30 | 2014-06-11 | 通用电气公司 | Method and apparatus for detecting marker protein |
| JP2018533017A (en) * | 2015-10-02 | 2018-11-08 | ティージーアール バイオサイエンシス ピーティーワイ エルティーディー． | Specimen detection with multiple substrates |
| CN111398580B (en) * | 2017-11-03 | 2023-06-13 | 科美诊断技术股份有限公司 | Method for detecting target IgM antibody in sample |
| CN109752332A (en) * | 2017-11-07 | 2019-05-14 | 重庆中元汇吉生物技术有限公司 | A kind of C1Q detection kit |
| CN108490194A (en) * | 2018-02-11 | 2018-09-04 | 北京科美生物技术有限公司 | Detect the homogeneous immunological detection reagent suit and its preparation method and application of follicular stimulating hormone |
| CN108445238A (en) * | 2018-02-11 | 2018-08-24 | 北京科美生物技术有限公司 | Detect the homogeneous immunological detection reagent suit and its preparation method and application of interstitialcellstimulating hormone (ICSH) |
| CN108445216B (en) * | 2018-02-11 | 2021-10-15 | 科美诊断技术股份有限公司 | Human anti-mullerian hormone determination kit and preparation method and application thereof |
| CN108169497A (en) * | 2018-02-11 | 2018-06-15 | 北京科美生物技术有限公司 | Human prolactin detection kit and preparation method and application |
| CN108445239B (en) * | 2018-02-11 | 2021-11-02 | 科美诊断技术股份有限公司 | Homogeneous phase immunoassay reagent kit for detecting beta human chorionic gonadotropin, and preparation method and application thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU633488B2 (en) * | 1988-04-04 | 1993-02-04 | Northwestern University | Binding of immune complexes by modified forms of c-reactive protein |
| US6140490A (en) * | 1996-02-01 | 2000-10-31 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US5283238A (en) * | 1992-04-24 | 1994-02-01 | Immtech International, Inc. | Methods of treating cancer using modified C-reactive protein |
| CA2170873A1 (en) * | 1993-09-03 | 1995-03-09 | Dariush Davalian | Fluorescent oxygen channeling immunoassays |
| US6303325B1 (en) * | 1998-05-29 | 2001-10-16 | Dade Behring Inc. | Method for detecting analytes |
-
2002
- 2002-06-12 DE DE10226011A patent/DE10226011A1/en not_active Withdrawn
-
2003
- 2003-06-10 MX MXPA04012232A patent/MXPA04012232A/en not_active Application Discontinuation
- 2003-06-10 WO PCT/EP2003/006038 patent/WO2003107000A2/en not_active Application Discontinuation
- 2003-06-10 TW TW092115617A patent/TW200411179A/en unknown
- 2003-06-10 RU RU2005100042/15A patent/RU2005100042A/en not_active Application Discontinuation
- 2003-06-10 CA CA002489021A patent/CA2489021A1/en not_active Abandoned
- 2003-06-10 JP JP2004513768A patent/JP2005529348A/en active Pending
- 2003-06-10 CN CNA03813442XA patent/CN1745300A/en active Pending
- 2003-06-10 BR BR0311709-0A patent/BR0311709A/en not_active IP Right Cessation
- 2003-06-10 EP EP03759923A patent/EP1516187A2/en not_active Withdrawn
- 2003-06-10 AU AU2003250344A patent/AU2003250344A1/en not_active Abandoned
- 2003-06-10 AR ARP030102067A patent/AR040259A1/en unknown
-
2004
- 2004-11-17 ZA ZA200409199A patent/ZA200409199B/en unknown
-
2005
- 2005-01-04 NO NO20050037A patent/NO20050037L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0311709A (en) | 2005-03-15 |
| CN1745300A (en) | 2006-03-08 |
| WO2003107000A3 (en) | 2004-05-27 |
| MXPA04012232A (en) | 2005-02-25 |
| TW200411179A (en) | 2004-07-01 |
| DE10226011A1 (en) | 2004-01-08 |
| ZA200409199B (en) | 2005-05-18 |
| AU2003250344A1 (en) | 2003-12-31 |
| CA2489021A1 (en) | 2003-12-24 |
| JP2005529348A (en) | 2005-09-29 |
| EP1516187A2 (en) | 2005-03-23 |
| WO2003107000A2 (en) | 2003-12-24 |
| RU2005100042A (en) | 2006-07-20 |
| NO20050037L (en) | 2005-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |