AR038556A1 - Composiciones y metodos para evaluar utilizacion del receptor/co-receptor viral e inhibidores de la entrada viral usando ensayos con virus recombinantes - Google Patents
Composiciones y metodos para evaluar utilizacion del receptor/co-receptor viral e inhibidores de la entrada viral usando ensayos con virus recombinantesInfo
- Publication number
- AR038556A1 AR038556A1 ARP030100519A ARP030100519A AR038556A1 AR 038556 A1 AR038556 A1 AR 038556A1 AR P030100519 A ARP030100519 A AR P030100519A AR P030100519 A ARP030100519 A AR P030100519A AR 038556 A1 AR038556 A1 AR 038556A1
- Authority
- AR
- Argentina
- Prior art keywords
- cell
- magnitude
- viral
- nucleic acid
- patient
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 6
- 230000003612 virological effect Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000007502 viral entry Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 10
- 102000039446 nucleic acids Human genes 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 6
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002245 particle Substances 0.000 abstract 3
- 101710091045 Envelope protein Proteins 0.000 abstract 2
- 101710188315 Protein X Proteins 0.000 abstract 2
- 102100021696 Syncytin-1 Human genes 0.000 abstract 2
- 108010067390 Viral Proteins Proteins 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Physiology (AREA)
- AIDS & HIV (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente se refiere a un método para identificar si un compuesto inhibe la entrada de un virus a una célula que comprende: (a) obtener ácido nucleico que codifica una proteína de envoltura viral de un paciente infectado por el virus; (b) co-transfectar dentro de una primera célula (i) el ácido nucleico de la etapa (a), y (ii) un vector de expresión viral que carece del ácido nucleico que codifica una proteína de envoltura, y que comprende un ácido nucleico indicador que produce una senal detectable, de modo que la primera célula produce partículas virales que comprenden la proteína de envoltura codificada por el ácido nucleico obtenido del paciente; (c) poner en contacto las partículas virales producidas en la etapa (b) con una segunda célula en presencia del compuesto, donde la segunda célula expresa un receptor de superficie celular al que se une el virus; (d) medir la magnitud de la senal producida por la segunda célula con el objeto de determinar la infectividad de las partículas virales; y (e) comparar la magnitud de la senal medida en la etapa (d) con la magnitud de la senal producida en ausencia del compuesto, donde una reducción en la magnitud de la senal medida en presencia del compuesto indica que el compuesto inhibe la entrada del virus a la segunda célula. Reivindicación 1: Un método para detectar en un paciente infectado por un virus, el desarrollo de un anticuerpo capaz de bloquear la infección, que comprende: (a) poner en contacto la célula huésped con una preparación de anticuerpo del paciente, donde la célula huésped comprende un ácido nucleico que codifica una proteína viral del paciente y un ácido nucleico que produce una senal detectable; (b) medir la magnitud de la senal detectable producida por la célula huésped; y (c) comparar la magnitud de la senal medida en la etapa (b) con la magnitud de la senal producida en ausencia de la preparación de anticuerpo, donde una reducción en la magnitud de la senal medida en presencia de la preparación de anticuerpo indica que el paciente ha desarrollado una respuesta de anticuerpos a la proteína viral capaz de bloquear la infección.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/077,027 US7247439B1 (en) | 2001-06-04 | 2002-02-15 | Method of evaluating a patient antibody response to envelope proteins of a virus |
Publications (1)
Publication Number | Publication Date |
---|---|
AR038556A1 true AR038556A1 (es) | 2005-01-19 |
Family
ID=27752685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030100519A AR038556A1 (es) | 2002-02-15 | 2003-02-17 | Composiciones y metodos para evaluar utilizacion del receptor/co-receptor viral e inhibidores de la entrada viral usando ensayos con virus recombinantes |
Country Status (11)
Country | Link |
---|---|
US (5) | US7247439B1 (es) |
EP (3) | EP2363506B1 (es) |
JP (1) | JP2006506944A (es) |
CN (1) | CN1646706A (es) |
AR (1) | AR038556A1 (es) |
AU (1) | AU2003217399A1 (es) |
CA (1) | CA2476365C (es) |
ES (3) | ES2474193T3 (es) |
HK (2) | HK1073486A1 (es) |
TW (1) | TW200303922A (es) |
WO (1) | WO2003070985A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030108857A1 (en) * | 2001-06-04 | 2003-06-12 | Parkin Neil T. | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS |
WO2002027321A2 (en) * | 2000-09-26 | 2002-04-04 | Health Research Incorporated | Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients |
US7718356B2 (en) * | 2000-09-26 | 2010-05-18 | Health Research Inc. | Heteroduplex tracking assay |
US7344830B2 (en) * | 2000-09-26 | 2008-03-18 | Health Research Inc. | Heteroduplex tracking assay |
US7247439B1 (en) * | 2001-06-04 | 2007-07-24 | Monogram Biosciences, Inc. | Method of evaluating a patient antibody response to envelope proteins of a virus |
US7097970B2 (en) | 2001-06-04 | 2006-08-29 | Monogram Biosciences, Inc. | Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs |
US8603736B2 (en) * | 2004-06-07 | 2013-12-10 | Monogram Biosciences, Inc. | Compositions and methods for determining resistance to inhibitors of virus entry using recombinant virus assays |
WO2006133266A2 (en) | 2005-06-06 | 2006-12-14 | Monogram Biosciences, Inc. | Methods for determining resistance or susceptibility to hiv entry inhibitors |
CA2658227A1 (en) * | 2006-01-17 | 2007-07-26 | Health Research, Inc. | Heteroduplex tracking assay |
US8114585B2 (en) | 2006-06-13 | 2012-02-14 | Monogram Biosciences, Inc. | Method for determining human immunodeficiency virus (HIV) coreceptor utilization by examining gp41 molecular determinants |
EP1914309A1 (en) * | 2006-10-20 | 2008-04-23 | Eurofins Viralliance Inc. | Method of assaying HIV-1 tropism for CCR5 and/or CXCR4 co-receptor and/or susceptibility to entry inhibitors |
WO2008047227A2 (en) * | 2006-10-20 | 2008-04-24 | Eurofins Viralliance Inc. | Method of assaying hiv-1 tropism for ccr5 and/or cxcr4 co-receptor and/or susceptibility to entry inhibitors |
US9732324B2 (en) | 2008-10-23 | 2017-08-15 | Cornell University | Anti-viral method |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US196551A (en) * | 1877-10-30 | Improvement in lamp-founts | ||
US6242187B1 (en) | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
AU732255B2 (en) | 1996-01-29 | 2001-04-12 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
US5837464A (en) | 1996-01-29 | 1998-11-17 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
US5939320A (en) | 1996-05-20 | 1999-08-17 | New York University | G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof |
US7247425B2 (en) * | 1998-01-30 | 2007-07-24 | Evolutionary Genomics, Llc | Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions |
US6103462A (en) | 1998-05-29 | 2000-08-15 | Institut Pasteur | Rapid single-cycle assay for human immunodeficiency virus type-1 drug resistance |
US6410013B1 (en) | 1999-01-25 | 2002-06-25 | Musc Foundation For Research Development | Viral vectors for use in monitoring HIV drug resistance |
US6406911B1 (en) | 1999-01-25 | 2002-06-18 | Musc Foundation For Research Development | Compositions and methods for sensitive detection of HIV infection and monitoring of drug resistance |
US7097970B2 (en) * | 2001-06-04 | 2006-08-29 | Monogram Biosciences, Inc. | Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs |
EP1402076B1 (en) | 2001-06-04 | 2012-08-01 | Monogram BioSciences, Inc. | Methods for evaluating patient treatment by inhibitors of virus entry using recombinant virus assays |
US7247439B1 (en) | 2001-06-04 | 2007-07-24 | Monogram Biosciences, Inc. | Method of evaluating a patient antibody response to envelope proteins of a virus |
US20040110125A1 (en) * | 2001-06-04 | 2004-06-10 | Petropoulos Christos J. | Compositions and methods for evaluating viral receptor/co-receptor usage and inhibitors of virus entry using recombinant virus assays |
US20040110124A1 (en) | 2002-10-07 | 2004-06-10 | Knox Susan Jane | Method of enhancing radiation resistance of normal cells |
US8603736B2 (en) * | 2004-06-07 | 2013-12-10 | Monogram Biosciences, Inc. | Compositions and methods for determining resistance to inhibitors of virus entry using recombinant virus assays |
HK1073488A1 (en) | 2005-06-23 | 2005-10-07 | Rolex Sa | Watch or piece of jewellery resistant to decoloration |
US7240970B2 (en) * | 2005-09-14 | 2007-07-10 | New York Air Brake Corporation | Trail locomotive brake control |
US9581595B2 (en) * | 2007-02-26 | 2017-02-28 | Laboratory Corporation Of America Holdings | Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy |
US9195155B2 (en) * | 2013-10-07 | 2015-11-24 | Xerox Corporation | Toner processes |
-
2002
- 2002-02-15 US US10/077,027 patent/US7247439B1/en not_active Expired - Lifetime
-
2003
- 2003-02-14 CA CA2476365A patent/CA2476365C/en not_active Expired - Lifetime
- 2003-02-14 ES ES03713444.2T patent/ES2474193T3/es not_active Expired - Lifetime
- 2003-02-14 ES ES14166270.0T patent/ES2633990T3/es not_active Expired - Lifetime
- 2003-02-14 US US10/504,921 patent/US20050214743A1/en not_active Abandoned
- 2003-02-14 TW TW092103099A patent/TW200303922A/zh unknown
- 2003-02-14 AU AU2003217399A patent/AU2003217399A1/en not_active Abandoned
- 2003-02-14 EP EP11000425.6A patent/EP2363506B1/en not_active Expired - Lifetime
- 2003-02-14 EP EP14166270.0A patent/EP2808404B1/en not_active Expired - Lifetime
- 2003-02-14 WO PCT/US2003/004373 patent/WO2003070985A1/en active Application Filing
- 2003-02-14 ES ES11000425.6T patent/ES2478943T3/es not_active Expired - Lifetime
- 2003-02-14 JP JP2003569876A patent/JP2006506944A/ja active Pending
- 2003-02-14 EP EP03713444.2A patent/EP1481098B1/en not_active Expired - Lifetime
- 2003-02-14 CN CNA038085364A patent/CN1646706A/zh active Pending
- 2003-02-17 AR ARP030100519A patent/AR038556A1/es unknown
-
2005
- 2005-06-01 HK HK05104635.8A patent/HK1073486A1/xx not_active IP Right Cessation
-
2009
- 2009-12-10 US US12/635,539 patent/US9175355B2/en not_active Expired - Lifetime
-
2012
- 2012-03-07 HK HK12102356.0A patent/HK1169145A1/xx not_active IP Right Cessation
-
2015
- 2015-10-29 US US14/926,837 patent/US9841425B2/en not_active Expired - Lifetime
-
2017
- 2017-12-11 US US15/838,046 patent/US20190025305A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1481098B1 (en) | 2014-03-26 |
EP2363506B1 (en) | 2014-04-30 |
CN1646706A (zh) | 2005-07-27 |
EP2808404B1 (en) | 2017-05-31 |
HK1169145A1 (en) | 2013-01-18 |
AU2003217399A1 (en) | 2003-09-09 |
US9841425B2 (en) | 2017-12-12 |
US20050214743A1 (en) | 2005-09-29 |
CA2476365C (en) | 2014-07-08 |
US7247439B1 (en) | 2007-07-24 |
EP2363506A1 (en) | 2011-09-07 |
EP1481098A4 (en) | 2007-08-22 |
US9175355B2 (en) | 2015-11-03 |
EP1481098A1 (en) | 2004-12-01 |
CA2476365A1 (en) | 2003-08-28 |
ES2478943T3 (es) | 2014-07-23 |
JP2006506944A (ja) | 2006-03-02 |
US20190025305A1 (en) | 2019-01-24 |
ES2474193T3 (es) | 2014-07-08 |
WO2003070985A1 (en) | 2003-08-28 |
EP2808404A1 (en) | 2014-12-03 |
US20110033836A1 (en) | 2011-02-10 |
TW200303922A (en) | 2003-09-16 |
HK1073486A1 (en) | 2005-10-07 |
ES2633990T3 (es) | 2017-09-26 |
US20160209411A1 (en) | 2016-07-21 |
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