AR035781A1 - P-tienilbencil- amidas como agonistas de receptores de angiotensina - (1-7), procedimiento para su preparacion, su utilizacion para la manufactura de un medicamento y composiciones farmaceuticas que los contienen - Google Patents
P-tienilbencil- amidas como agonistas de receptores de angiotensina - (1-7), procedimiento para su preparacion, su utilizacion para la manufactura de un medicamento y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR035781A1 AR035781A1 ARP020100882A ARP020100882A AR035781A1 AR 035781 A1 AR035781 A1 AR 035781A1 AR P020100882 A ARP020100882 A AR P020100882A AR P020100882 A ARP020100882 A AR P020100882A AR 035781 A1 AR035781 A1 AR 035781A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- halogen
- radical
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
P-tienilbencil-amidas que comprenden compuestos de la fórmula (1) en los cuales los radicales indicados tienen el siguiente significado: R1 es alquilo(C1-5), no sustituido o sustituido con un radical de la serie NH2, halógeno, O-alquilo(C1-3), CO-O-alquilo(C1-3) y CO2H; cicloalquilo(C3-8); alquil(C1-3)-cicloalquilo(C3-8); arilo(C6-10) no sustituido o sustituido con un radical de la serie halógeno y O-alquilo(C1-3); alquil(C1-3)-arilo(C6-10), en el que el radical arilo no está sustituido o está sustituido con un radical de la serie halógeno y O-alquilo(C1-3); heteroarilo(C1-5); y alquil(C1-3)-heteroarilo(C1-5); R2 es nitrógeno; alquilo(C1-6), no sustituido o sustituido con un radical de la serie de halógeno y O-alquilo(C1-3); cicloalquilo(C3-8); alquil(C1-3)-cicloalquilo(C3-8); arilo(C6-10), no sustituido o sustituido con un radical de la serie halógeno, O-alquilo(C1-3) y CO-O-alquilo(C1-3); y alquil(C1-3)-arilo(C6-10), no sustituido o sustituido con un radical de la serie halógeno, O-alquilo(C1-3); R3 es hidrógeno; COOH; y COO-alquilo(C1-4); R4 es hidrógeno; halógeno; y alquilo(C1-4); R5 es hidrógeno; y alquilo(C1-6); R6 es hidrógeno; alquilo(C1-6); alquil(C1-3)-cicloalquilo(C3-8); y alquenilo(C2-6); y X es oxígeno y NH; en todas sus formas estereoisómeras y mezclas de ellas, en todas las relaciones, y sus sales fisiológicamente compatibles; un procedimiento para su preparación, composiciones farmacéuticas y el uso de los mismos para la manufactura de medicamentos para tratar enfermedad cardíaca coronaria, angina de pecho. Los compuestos de la fórmula (1) representan potentes agonistas de receptores de angiotensina-(1-7). En virtud de la estimulación de estos receptores, provocada por los compuestos de la fórmula (1) y, unido con ello, de la producción y liberación en células endoteliales de las sustancias mensajero monofosfato cíclico de guanosina (cGMP) y monóxido de nitrógeno (NO), vasorrelajantes y cardioprotectoras, los compuestos de la fórmula (1) son adecuados como valiosos principio activos medicamentosos para el tratamiento y la prevención de hipertensión-sanguínea, hipertrofia de corazón, insuficiencia cardíaca, enfermedades cardíacas coronarias tales como angina de pecho, y de una disfunción endotelial o, respectivamente, lesiones endoteliales, por ejemplo como consecuencia de procesos ateroscleróticos, o en caso de diabetes mellitus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10112041A DE10112041A1 (de) | 2001-03-14 | 2001-03-14 | p-Thienylbenzyl-Amide als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035781A1 true AR035781A1 (es) | 2004-07-14 |
Family
ID=7677277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020100882A AR035781A1 (es) | 2001-03-14 | 2002-03-12 | P-tienilbencil- amidas como agonistas de receptores de angiotensina - (1-7), procedimiento para su preparacion, su utilizacion para la manufactura de un medicamento y composiciones farmaceuticas que los contienen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6538144B2 (es) |
| EP (1) | EP1370548B1 (es) |
| JP (1) | JP4291578B2 (es) |
| AR (1) | AR035781A1 (es) |
| AT (1) | ATE316968T1 (es) |
| CA (1) | CA2440647A1 (es) |
| DE (2) | DE10112041A1 (es) |
| IL (1) | IL157890A0 (es) |
| MX (1) | MXPA03007635A (es) |
| PE (1) | PE20020910A1 (es) |
| WO (1) | WO2002072569A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003232884A1 (en) | 2002-01-25 | 2003-09-02 | Emory University | Solenopsin a, b and analogs as novel angiogenesis inhibitors |
| CA2484822A1 (en) * | 2002-05-28 | 2003-12-04 | 3-Dimensional Pharmaceuticals, Inc. | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
| AU2003286251A1 (en) * | 2002-11-21 | 2004-06-15 | Vicore Pharma Ab | New bicyclic angiotensin ii agonists |
| AU2003219291A1 (en) * | 2003-03-24 | 2004-10-18 | Vicore Pharma Ab | Bicyclic compounds useful as angiotensin ii agonists |
| WO2005077331A1 (en) * | 2004-02-11 | 2005-08-25 | Athpharma Limited | Chronotherapeutic compositions and methods of their use |
| WO2006047289A2 (en) * | 2004-10-21 | 2006-05-04 | Medtronic, Inc. | Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function |
| MX2007012635A (es) * | 2005-04-12 | 2008-01-11 | Vicore Pharma Ab | Nuevos agonistas de angiotensina ii triciclica. |
| IN2014DN02217A (es) | 2005-04-12 | 2015-07-10 | Vicore Pharma Ab | |
| US8080571B2 (en) * | 2005-04-12 | 2011-12-20 | Vicore Pharma Ab | Tricyclic angiotensin II agonists |
| US20100055147A1 (en) * | 2006-10-27 | 2010-03-04 | Edze Jan Tijsma | Angiotensin (1-7) eluting stent |
| BRPI0806230A2 (pt) * | 2007-01-26 | 2021-05-25 | Universidade Federal De Minas Gerais - Ufmg | composições farmacêuticas, método para tratar a disfunção erétil e método para restaurar a capacidade de ereção |
| US8926536B2 (en) | 2009-08-07 | 2015-01-06 | The Seaberg Company, Inc. | Device and method for control of hemorrhage |
| US9028435B2 (en) | 2011-08-12 | 2015-05-12 | The Seaberg Company, LLC | Device and method for control of hemorrhage |
| US10258347B2 (en) | 2014-02-04 | 2019-04-16 | The Seaberg Company, Inc. | Extremity tourniquet |
| US10363046B2 (en) | 2012-12-04 | 2019-07-30 | The Seaberg Company, Inc. | Extremity tourniquet with locking buckle |
| KR20170026368A (ko) | 2014-07-17 | 2017-03-08 | 유니버시티 오브 써던 캘리포니아 | 근골격 질환들의 치료를 위한 방법들, 화합물들 및 조성물들 |
| WO2018005591A1 (en) | 2016-06-29 | 2018-01-04 | Universite De Montreal | Biarylmethyl heterocycles |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177074A (en) * | 1991-03-26 | 1993-01-05 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
| US5198438A (en) * | 1991-05-07 | 1993-03-30 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating a substituted thiophene or furan |
| US5444067A (en) * | 1993-08-30 | 1995-08-22 | Merck & Co., Inc. | Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety |
| YU78601A (sh) | 1999-05-05 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže |
-
2001
- 2001-03-14 DE DE10112041A patent/DE10112041A1/de not_active Withdrawn
-
2002
- 2002-03-06 DE DE50205752T patent/DE50205752D1/de not_active Expired - Lifetime
- 2002-03-06 MX MXPA03007635A patent/MXPA03007635A/es unknown
- 2002-03-06 AT AT02722180T patent/ATE316968T1/de not_active IP Right Cessation
- 2002-03-06 WO PCT/EP2002/002422 patent/WO2002072569A1/de active IP Right Grant
- 2002-03-06 CA CA002440647A patent/CA2440647A1/en not_active Abandoned
- 2002-03-06 EP EP02722180A patent/EP1370548B1/de not_active Expired - Lifetime
- 2002-03-06 IL IL15789002A patent/IL157890A0/xx unknown
- 2002-03-06 JP JP2002571485A patent/JP4291578B2/ja not_active Expired - Fee Related
- 2002-03-12 AR ARP020100882A patent/AR035781A1/es unknown
- 2002-03-13 US US10/095,584 patent/US6538144B2/en not_active Expired - Lifetime
- 2002-03-14 PE PE2002000202A patent/PE20020910A1/es not_active Application Discontinuation
- 2002-12-05 US US10/310,055 patent/US6984660B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1370548B1 (de) | 2006-02-01 |
| DE10112041A1 (de) | 2002-09-26 |
| JP2004527507A (ja) | 2004-09-09 |
| US6538144B2 (en) | 2003-03-25 |
| US6984660B2 (en) | 2006-01-10 |
| DE50205752D1 (de) | 2006-04-13 |
| ATE316968T1 (de) | 2006-02-15 |
| US20030144343A1 (en) | 2003-07-31 |
| IL157890A0 (en) | 2004-03-28 |
| EP1370548A1 (de) | 2003-12-17 |
| US20020188139A1 (en) | 2002-12-12 |
| MXPA03007635A (es) | 2003-12-04 |
| WO2002072569A1 (de) | 2002-09-19 |
| CA2440647A1 (en) | 2002-09-19 |
| PE20020910A1 (es) | 2002-11-26 |
| JP4291578B2 (ja) | 2009-07-08 |
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