AR030529A1 - Derivados de acido 2- acetidincarboxilico, composiciones farmaceuticas que los comprenden y el uso de los mismos para preparar un medicamento - Google Patents
Derivados de acido 2- acetidincarboxilico, composiciones farmaceuticas que los comprenden y el uso de los mismos para preparar un medicamentoInfo
- Publication number
- AR030529A1 AR030529A1 ARP000103483A ARP000103483A AR030529A1 AR 030529 A1 AR030529 A1 AR 030529A1 AR P000103483 A ARP000103483 A AR P000103483A AR P000103483 A ARP000103483 A AR P000103483A AR 030529 A1 AR030529 A1 AR 030529A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- branched
- group
- substituted phenyl
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de ácido 2-acetidincarboxílico neurotrofico, caracterizados porque comprenden un compuesto de la formula (1) o una sal farmacéuticamente aceptable de ella, donde (a) R1 se selecciona del grupo que consiste en: (i) COCOR2, donde R2 es un alquilo ramificado o derecho de (C1-6), alquenilo ramificado o derecho de (C2-6), cicloalquilo de (C5-7), 2-tienilo, 3-tienilo, fenilo o fenilo sustituido (el anillo de fenilo sustituido posee de uno a tres sustituyentes seleccionados en forma independiente del grupo que consiste en alquilo inferior, alcoxi inferior, hidroxi y halogeno), (ii) CONHR3, donde R3 es alquilo ramificado o derecho de (C1-6), (iii) SO2R4, donde R4 es fenilalquilo o fenilalquilo sustituido (el anillo de fenilo sustituido posee de uno a tres sustituyentes seleccionados en forma independiente del grupo que consiste en alquilo inferior, alcoxi inferior, hidroxi y halogeno), (iv) un heterociclo de formula (2) donde la porcion del anillo del mismo es aromático y contiene opcionalmente uno o más heteroátomos seleccionados del grupo que consiste en oxígeno, sulfuro y nitrogeno; (b) X e Y son (i) C=O u (ii) O o NR5 (donde R5 es alquilo ramificado o derecho de (C1-6)), respectivamente, o en forma alternativa juntos forman un anillo de tetrazol 1,5-disustituido; (a) Z es un alquilo ramificado o derecho de (C1-5) o alquenilo sustituido en una o más posiciones con Ar, donde Ar se selecciona del grupo que consiste en 2-piridil, 3-pridil, 4-piridil, fenilo y fenilo sustituido (el anillo de fenilo sustituido tiene desde uno hasta tres sustituyentes seleccionados en forma independiente de alquilo inferior, alcoxi inferior, hidroxi y halogeno), con la condicion de que Z y R2 no pueden ser ambos alquilo de C1; y (b) A es X-Y-Z o hidrogeno. También suministra composiciones farmacéuticas que comprenden lo mismos; usos de los mismos para preparar medicamentos para tratar y prevenir trastornos caracterizados por dano neuronal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14300199P | 1999-07-09 | 1999-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030529A1 true AR030529A1 (es) | 2003-08-27 |
Family
ID=22502144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000103483A AR030529A1 (es) | 1999-07-09 | 2000-07-07 | Derivados de acido 2- acetidincarboxilico, composiciones farmaceuticas que los comprenden y el uso de los mismos para preparar un medicamento |
Country Status (4)
Country | Link |
---|---|
US (1) | US6544976B1 (es) |
AR (1) | AR030529A1 (es) |
AU (1) | AU5483500A (es) |
WO (1) | WO2001004091A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0119435D0 (en) * | 2001-02-15 | 2001-10-03 | Aventis Pharm Prod Inc | Method of treating of demyelinating diseases or conditions |
DE60204046T2 (de) | 2001-10-04 | 2006-01-19 | Ortho-Mcneil Pharmaceutical, Inc. | N-heterocyclylhydrazide als neurotrophe mittel |
MX2007007553A (es) * | 2004-12-24 | 2007-08-15 | Prosidion Ltd | Agonistas del receptor acoplado a proteina g (gpr116) y uso de los mismos para tratar obesidad y diabetes. |
WO2008135525A2 (en) * | 2007-05-02 | 2008-11-13 | Boehringer Ingelheim International Gmbh | Substituted azetidines, manufacturing and use thereof as medicaments |
EP2443107B1 (en) * | 2009-06-16 | 2018-08-08 | Boehringer Ingelheim International GmbH | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950649A (en) | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
CA2102180C (en) * | 1991-05-09 | 2002-07-23 | David M. Armistead | Novel immunosuppressive pyrrolidine/piperidine/azepane-2-carboxylic acid derivatives |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5614547A (en) | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US5696135A (en) | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
IL118279A (en) | 1995-06-07 | 2006-10-05 | Abbott Lab | Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5786378A (en) | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
AR010744A1 (es) | 1996-12-09 | 2000-07-12 | Guildford Pharmaceuticals Inc | Inhibidores polipropilos de ciclofilina |
US5935989A (en) | 1996-12-31 | 1999-08-10 | Gpi Nil Holdings Inc. | N-linked ureas and carbamates of heterocyclic thioesters |
US5874449A (en) | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
ZA98825B (en) | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
ATE262519T1 (de) * | 1997-12-19 | 2004-04-15 | Abbott Lab | Heterozyklische ether- und thioether-verbindungen,verwendbar zur steuerung von chemischer synaptischer transmission |
GB9804426D0 (en) | 1998-03-02 | 1998-04-29 | Pfizer Ltd | Heterocycles |
-
2000
- 2000-06-12 AU AU54835/00A patent/AU5483500A/en not_active Abandoned
- 2000-06-12 US US09/592,531 patent/US6544976B1/en not_active Expired - Lifetime
- 2000-06-12 WO PCT/US2000/016136 patent/WO2001004091A1/en active Application Filing
- 2000-07-07 AR ARP000103483A patent/AR030529A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US6544976B1 (en) | 2003-04-08 |
WO2001004091A1 (en) | 2001-01-18 |
AU5483500A (en) | 2001-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2207770T3 (da) | 1, 2, 3-triazolderivater til anvendelse som stearoyl-coa desaturase-inhibitorer | |
UY28132A1 (es) | Derivados de pirrolopirimidina | |
BR0010746A (pt) | Derivados heterocìclicos úteis com agentes anticâncer | |
BRPI0014526B8 (pt) | compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo | |
AR063602A1 (es) | Derivados de espiroindolinona, formulaciones farmaceuticas que los contienen y su uso en la obtencion de un medicamento para el tratamiento de trastornos oncologicos. | |
HUP0402313A2 (hu) | Szerotonin újrafelvételt gátló fenilpiperazin-származékok, az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
KR950704304A (ko) | 이환식 헤테로환 함유 술폰아미드 및 술폰산 에스테르 유도체(bicyclic heterocyclic sulfonamide and sulfonic ester derivatives) | |
ATE476431T1 (de) | Piperidin- und azetidinderivate als glyt1- inhibitoren | |
DK1178982T3 (da) | Heterocykliske, substituerede aminoazacykliske forbindelser, der er nyttige som midler til centralnervesystemet | |
UY25332A1 (es) | Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgésicos | |
DE50011034D1 (de) | N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
NO324219B1 (no) | Fenylpyridazin-forbindelser, medisiner og farmasoytiske preparater inneholdende disse samt anvendelse av disse for fremstilling av medikamenter for behandling av sykdom | |
AR030529A1 (es) | Derivados de acido 2- acetidincarboxilico, composiciones farmaceuticas que los comprenden y el uso de los mismos para preparar un medicamento | |
PE20091079A1 (es) | Compuestos heterociclicos como moduladores npy y2 | |
AR044014A1 (es) | Composiciones farmaceuticas para administracion intranasal de acido [2-(8,9-dioxo-2, 6-diazabiciclo [5.2.0) non-1 (7) -en-2-il)alquil]-fosfonico y derivados y metodos de utilizacion de las mismas | |
KR950032147A (ko) | 아실화된 아미노알칸이미다졸 및 -트리아졸 | |
UA74341C2 (uk) | Похідні борелідину, які інгібують ангіогенез | |
AR029897A1 (es) | Derivados de ciclobuteno, composiciones farmaceuticas y uso de los derivados para preparar medicamentos | |
KR970702845A (ko) | 신규의 히드록시믹산 유도체, 그를 포함한 약제학적 조성물 및 그의 제조방법 | |
DE60003671D1 (de) | Halo-derivate von 9-deoxo-9a-aza-9a-homerythromycin a | |
AR009144A1 (es) | Compuestos heterociclicos guanidilamino, composicion farmaceutica que comprende dicho compuesto y uso del mismo para la fabricacion de un medicamento | |
DE3764667D1 (de) | Substituierte carbonsaeureamide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen. | |
FI935690A0 (fi) | Oralt aktiva antivirala foereningar | |
AR012030A1 (es) | Derivados de 1-acil-1,2-dihidroquinolina 2-substituida, el uso de los mismos para la fabricacion de un medicamento y una composicion farmaceutica. | |
GT200100120A (es) | Derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |