AR023451A1 - DERIVATIVES OF 1-AMINO ETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS - Google Patents

DERIVATIVES OF 1-AMINO ETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Info

Publication number
AR023451A1
AR023451A1 ARP000101669A ARP000101669A AR023451A1 AR 023451 A1 AR023451 A1 AR 023451A1 AR P000101669 A ARP000101669 A AR P000101669A AR P000101669 A ARP000101669 A AR P000101669A AR 023451 A1 AR023451 A1 AR 023451A1
Authority
AR
Argentina
Prior art keywords
hydrogen atom
alkyl
group
ethylindol
therapeutics
Prior art date
Application number
ARP000101669A
Other languages
Spanish (es)
Original Assignee
Addario Ezio Nicola D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addario Ezio Nicola D filed Critical Addario Ezio Nicola D
Publication of AR023451A1 publication Critical patent/AR023451A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Compuestos de formula general (1) en la cual: A representa un átomo de hidrogeno, un halogeno o un hidroxi; B y D representan, independientemente entre sí,un átomo de hidrogeno o un grupo alquilo C1-3; R1 representa un átomo de hidrogeno, un grupo alquilo C1-4, fluoroalquilo C1-2 o perfluoroalquilo C1-2; R2representa un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, cicloalquilo C3-6, fluoroalquilo C1-2, perfluoroalquilo C1-2 o un fenilo; R3 y R4representan, independientemente entre sí,un átomo de hidrogeno, un halogeno o un grupo alquilo C1-6; R5 y R6 representan, independientemente entre sí, unátomo de hidrogeno, un grupo alquilo C1-6 o fluoroalquilo C1-2, o R5 y R6, juntos, forman una cadena alquileno C2-7. Aplicacion en terapéutica. Tienenactividad contráctil sobre los musculos lisos uretrales y arteriales.Compounds of general formula (1) in which: A represents a hydrogen atom, a halogen or a hydroxy; B and D represent, independently of each other, a hydrogen atom or a C1-3 alkyl group; R1 represents a hydrogen atom, a C1-4 alkyl, C1-2 fluoroalkyl or C1-2 perfluoroalkyl group; R2 represents a hydrogen atom, a halogen, a C1-6 alkyl, C3-6 cycloalkyl, C1-2 fluoroalkyl, C1-2 perfluoroalkyl or a phenyl group; R3 and R4 independently represent each other, a hydrogen atom, a halogen or a C1-6 alkyl group; R5 and R6 represent, independently of each other, hydrogen atom, a C1-6 alkyl or C1-2 fluoroalkyl group, or R5 and R6, together, form a C2-7 alkylene chain. Therapeutic application. It has contractile activity on the urethral and arterial smooth muscles.

ARP000101669A 1999-04-13 2000-04-12 DERIVATIVES OF 1-AMINO ETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS AR023451A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9904577A FR2792316B1 (en) 1999-04-13 1999-04-13 1-AMINOETHYLINDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
AR023451A1 true AR023451A1 (en) 2002-09-04

Family

ID=9544316

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101669A AR023451A1 (en) 1999-04-13 2000-04-12 DERIVATIVES OF 1-AMINO ETHYLINDOL, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS

Country Status (7)

Country Link
AR (1) AR023451A1 (en)
AU (1) AU3971400A (en)
CO (1) CO5180549A1 (en)
FR (1) FR2792316B1 (en)
PE (1) PE20010041A1 (en)
UY (1) UY26102A1 (en)
WO (1) WO2000061554A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077405A1 (en) 2009-07-10 2011-08-24 Sanofi Aventis DERIVATIVES OF INDOL INHIBITORS OF HSP90, COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF CANCER

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2752840A1 (en) * 1996-08-29 1998-03-06 Synthelabo 7-Amino ethyl benzothiophene derivatives
FR2752839B1 (en) * 1996-08-29 1998-10-09 Synthelabo BENZOFURANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
WO2000061554A1 (en) 2000-10-19
AU3971400A (en) 2000-11-14
FR2792316B1 (en) 2001-06-22
UY26102A1 (en) 2000-10-31
FR2792316A1 (en) 2000-10-20
PE20010041A1 (en) 2001-04-12
CO5180549A1 (en) 2002-07-30

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